File Info

Filename
.command.out
Full Path
s3://natera-rnd-pltf-dev-nextflow-scratch-01/work/3c/e3f060ef91ab35c837366c007d09a1/.command.out
Size
10.8 KB
Attempt
Analyzing demux output from: merged
Loading Demultiplex_Stats.csv from: merged/Reports/Demultiplex_Stats.csv
Loaded 388 rows from Demultiplex_Stats.csv

================================================================================
1. % UNDETERMINED PER LANE
================================================================================
Undetermined Summary per Lane:
      %_Undetermined  Undetermined_Reads  Total_Reads
Lane                                                 
1               5.22           211346066   4046804284
2               5.33           213604774   4005741146
3               5.18           210105409   4055602240
4               4.90           196957742   4015754163
5               3.56           144447804   4059237853
6               3.75           152658631   4075260777
7               3.85           158180325   4111566941
8               3.87           157368459   4070182884

================================================================================
2. SAMPLES WITH <1000000 READS (NON-NTC)
================================================================================
No samples found with <1000000 reads

================================================================================
3. NTC SAMPLES WITH >2000000 READS
================================================================================
Found 1 NTC samples with >2000000 reads:
                    SampleID                  Index  # Reads
0  NTC_0001_0001_23LGNLLT4_1  AATTGGCACA-CAGTCGGAGT  3344443

================================================================================
4. TOP UNKNOWN BARCODES (>0.05% OF LANE READS)
================================================================================
Loading Top_Unknown_Barcodes.csv from: merged/Reports/Top_Unknown_Barcodes.csv

Lane 1 - Found 14 barcodes with >0.05% of lane reads:
           index      index2   # Reads  Percentage_of_Lane  Percentage_of_Total
1001  CCAACTGTAT  GGGGGGGGGG  16512354              0.4080               0.0509
1002  GTGACGCACA  GGGGGGGGGG   6109919              0.1510               0.0188
1003  GAGTAGTGAC  GGGGGGGGGG   5095319              0.1259               0.0157
1004  GATAGGTGAA  GGGGGGGGGG   4626452              0.1143               0.0143
1005  AGACGACAGA  GGGGGGGGGG   4425791              0.1094               0.0136
1006  TGAGTGTACA  GGGGGGGGGG   3787896              0.0936               0.0117
1007  TAGCGAGGCT  GGGGGGGGGG   3727400              0.0921               0.0115
1008  AAGGTGTACT  GGGGGGGGGG   3677456              0.0909               0.0113
1009  CTCTATACTG  GGGGGGGGGG   3616335              0.0894               0.0111
1010  TGTGACGTAT  GGGGGGGGGG   3000754              0.0742               0.0093
1011  ACCAGGAATT  GGGGGGGGGG   2549661              0.0630               0.0079
1012  TAAGGCTCAC  GGGGGGGGGG   2174868              0.0537               0.0067
1013  ATCATACCGC  GGGGGGGGGG   2147851              0.0531               0.0066
1014  TCTCCGTACT  GGGGGGGGGG   2053900              0.0508               0.0063

Lane 2 - Found 14 barcodes with >0.05% of lane reads:
           index      index2   # Reads  Percentage_of_Lane  Percentage_of_Total
2001  CCAACTGTAT  GGGGGGGGGG  15161678              0.3785               0.0467
2002  GTGACGCACA  GGGGGGGGGG   5669869              0.1415               0.0175
2003  GAGTAGTGAC  GGGGGGGGGG   5064184              0.1264               0.0156
2004  GATAGGTGAA  GGGGGGGGGG   4188170              0.1046               0.0129
2005  AGACGACAGA  GGGGGGGGGG   4035783              0.1007               0.0124
2006  TAGCGAGGCT  GGGGGGGGGG   3606840              0.0900               0.0111
2007  TGAGTGTACA  GGGGGGGGGG   3514278              0.0877               0.0108
2008  AAGGTGTACT  GGGGGGGGGG   3471119              0.0867               0.0107
2009  CTCTATACTG  GGGGGGGGGG   3427535              0.0856               0.0106
2010  ATCCAGCATG  AGATCTCGGT   3346817              0.0836               0.0103
2011  TGTGACGTAT  GGGGGGGGGG   2561274              0.0639               0.0079
2012  ACCAGGAATT  GGGGGGGGGG   2473783              0.0618               0.0076
2013  ATCATACCGC  GGGGGGGGGG   2088118              0.0521               0.0064
2014  TAAGGCTCAC  GGGGGGGGGG   2028720              0.0506               0.0063

Lane 3 - Found 12 barcodes with >0.05% of lane reads:
           index      index2   # Reads  Percentage_of_Lane  Percentage_of_Total
4001  CCAACTGTAT  GGGGGGGGGG  15100371              0.3723               0.0465
4002  GTGACGCACA  GGGGGGGGGG   5596458              0.1380               0.0173
4003  GAGTAGTGAC  GGGGGGGGGG   4917015              0.1212               0.0152
4004  GATAGGTGAA  GGGGGGGGGG   4171417              0.1029               0.0129
4005  AGACGACAGA  GGGGGGGGGG   3959603              0.0976               0.0122
4006  TGAGTGTACA  GGGGGGGGGG   3470378              0.0856               0.0107
4007  TAGCGAGGCT  GGGGGGGGGG   3457160              0.0852               0.0107
4008  AAGGTGTACT  GGGGGGGGGG   3367739              0.0830               0.0104
4009  CTCTATACTG  GGGGGGGGGG   3290240              0.0811               0.0101
4010  ATCCAGCATG  AGATCTCGGT   3113478              0.0768               0.0096
4011  TGTGACGTAT  GGGGGGGGGG   2514623              0.0620               0.0078
4012  ACCAGGAATT  GGGGGGGGGG   2425246              0.0598               0.0075

Lane 4 - Found 12 barcodes with >0.05% of lane reads:
           index      index2   # Reads  Percentage_of_Lane  Percentage_of_Total
5001  CCAACTGTAT  GGGGGGGGGG  14837857              0.3695               0.0457
5002  GTGACGCACA  GGGGGGGGGG   5492973              0.1368               0.0169
5003  GAGTAGTGAC  GGGGGGGGGG   4397564              0.1095               0.0136
5004  GATAGGTGAA  GGGGGGGGGG   4211227              0.1049               0.0130
5005  AGACGACAGA  GGGGGGGGGG   3868534              0.0963               0.0119
5006  TGAGTGTACA  GGGGGGGGGG   3474004              0.0865               0.0107
5007  TAGCGAGGCT  GGGGGGGGGG   3315912              0.0826               0.0102
5008  AAGGTGTACT  GGGGGGGGGG   3173047              0.0790               0.0098
5009  CTCTATACTG  GGGGGGGGGG   3114019              0.0775               0.0096
5010  TGTGACGTAT  GGGGGGGGGG   2835605              0.0706               0.0087
5011  ACCAGGAATT  GGGGGGGGGG   2230348              0.0555               0.0069
5012  TAAGGCTCAC  GGGGGGGGGG   2041112              0.0508               0.0063

Lane 5 - Found 6 barcodes with >0.05% of lane reads:
           index      index2  # Reads  Percentage_of_Lane  Percentage_of_Total
6001  TTGGATTGTC  GGGGGGGGGG  6386285              0.1573               0.0197
6002  TGCAACACTA  GGGGGGGGGG  3653641              0.0900               0.0113
6003  TCGCATGACA  GGGGGGGGGG  3506075              0.0864               0.0108
6004  CATCAGGCGT  GGGGGGGGGG  3140590              0.0774               0.0097
6005  CCACCTGCTT  GGGGGGGGGG  3040546              0.0749               0.0094
6006  CCAGTGCACT  GGGGGGGGGG  2445200              0.0602               0.0075

Lane 6 - Found 6 barcodes with >0.05% of lane reads:
           index      index2  # Reads  Percentage_of_Lane  Percentage_of_Total
7001  TTGGATTGTC  GGGGGGGGGG  6897136              0.1692               0.0213
7002  TGCAACACTA  GGGGGGGGGG  3977480              0.0976               0.0123
7003  TCGCATGACA  GGGGGGGGGG  3856686              0.0946               0.0119
7004  CATCAGGCGT  GGGGGGGGGG  3410098              0.0837               0.0105
7005  CCACCTGCTT  GGGGGGGGGG  3267007              0.0802               0.0101
7006  CCAGTGCACT  GGGGGGGGGG  2652819              0.0651               0.0082

Lane 7 - Found 8 barcodes with >0.05% of lane reads:
           index      index2  # Reads  Percentage_of_Lane  Percentage_of_Total
3001  TTGGATTGTC  GGGGGGGGGG  7196004              0.1750               0.0222
3002  TGCAACACTA  GGGGGGGGGG  4140080              0.1007               0.0128
3003  TCGCATGACA  GGGGGGGGGG  4133143              0.1005               0.0127
3004  CATCAGGCGT  GGGGGGGGGG  3609071              0.0878               0.0111
3005  CCACCTGCTT  GGGGGGGGGG  3599203              0.0875               0.0111
3006  CCAGTGCACT  GGGGGGGGGG  2744600              0.0668               0.0085
3007  GAAGCAAGCG  GGGGGGGGGG  2170074              0.0528               0.0067
3008  ACAATAGCAC  GGGGGGGGGG  2116078              0.0515               0.0065

Lane 8 - Found 9 barcodes with >0.05% of lane reads:
        index      index2  # Reads  Percentage_of_Lane  Percentage_of_Total
0  TTGGATTGTC  GGGGGGGGGG  7535038              0.1851               0.0232
1  TGCAACACTA  GGGGGGGGGG  4232194              0.1040               0.0130
2  TCGCATGACA  GGGGGGGGGG  4042491              0.0993               0.0125
3  CATCAGGCGT  GGGGGGGGGG  3662512              0.0900               0.0113
4  CCACCTGCTT  GGGGGGGGGG  3431616              0.0843               0.0106
5  CCAGTGCACT  GGGGGGGGGG  2926417              0.0719               0.0090
6  GAAGCAAGCG  GGGGGGGGGG  2275317              0.0559               0.0070
7  ACAATAGCAC  GGGGGGGGGG  2140678              0.0526               0.0066
8  CGTACTTAGA  GGGGGGGGGG  2057009              0.0505               0.0063

================================================================================
5. BARCODES WITH HIGH MISMATCH RATES
================================================================================
No barcodes found with >20.0% mismatch rate

================================================================================
FINAL STATUS CHECK
================================================================================
Overall % Undetermined: 4.45%
Status: 🔴 FAIL
Reason(s):
  NTC sample NTC_0001_0001_23LGNLLT4_1 has 3,344,443 reads > 2,000,000
Thresholds: <5.0% = PASS, 5.0-10.0% = WARNING, >10.0% = FAIL
NTC gate: >2,000,000 reads = FAIL

=== Creating reports in . ===
QC summary saved to: ./qc_report.csv
Detailed QC report saved to: ./qc_report_detailed.txt
Fail file created: ./samplesheet_status.fail

================================================================================
QC SUMMARY
================================================================================
                        Metric       Value
                   Total_Reads 32440150288
        Total_Samples_Analyzed          96
               Number_of_Lanes           8
   Global_Percent_Undetermined       4.45%
Lanes_Exceeding_Fail_Threshold        None
        Samples_with_Low_Reads           0
   NTC_Samples_with_High_Reads           1
  Significant_Unknown_Barcodes          81
        High_Mismatch_Barcodes           0
                  Final_Status        FAIL

================================================================================
QC Analysis completed successfully!
Flowcell Status: FAIL
Reports generated:
  - ./qc_report.csv
  - ./qc_report_detailed.txt
  - ./samplesheet_status.fail
================================================================================