Downloading: s3://natera-rnd-pltf-dev-nextflow-scratch-01/work/31/d06dc23209d674790ce2726e26712e/.command.sh
  Downloading: s3://natera-rnd-pltf-dev-nextflow-scratch-01/work/2d/3aa496a5282059060cd7df47cc2a73/tih_rna_sample_00680_B23MVV7LT4_1.arriba.fusions.tsv
  Downloading: s3://natera-rnd-pltf-dev-nextflow-scratch-01/work/31/d06dc23209d674790ce2726e26712e/.command.run
  Downloading: s3://natera-platform-sandbox/pipeline-resources/AIH/rna/GRCh38/blacklist_breakpoint_database_2026-04-27.tsv
  Downloading: s3://natera-rnd-pltf-dev-nextflow-scratch-01/work/stage-7324c8a8-f474-426a-a5c9-715912777f94/d8/92d6652b0b8fcc763d0f3fff270437/arriba_filter_config.yaml
==> STAGING COMPLETE (5 inputs)

  AIH curated blacklist: matched 18 fusion rows (breakpoint_ID in qualified set)

================================================================================
ARRIBA FILTERING SUMMARY
================================================================================

Total fusions: 274
  Pass (FILTER=PASS): 44 (16.1%)
  Fail (FILTER=FAIL): 230 (83.9%)

AIH curated blacklist (blacklisted flag):
  Total blacklisted: 18
  All 18 blacklisted rows have FILTER=FAIL

Failure reasons (top 15):
  confidence_below_min(medium<high): 63
  confidence_below_min(low<high);total_reads_below_min(1.0<8.0): 49
  confidence_below_min(low<high);total_reads_below_min(0.0<8.0): 21
  confidence_below_min(low<high): 19
  confidence_below_min(medium<high);total_reads_below_min(3.0<8.0): 14
  confidence_below_min(low<high);total_reads_below_min(3.0<8.0): 7
  confidence_below_min(medium<high);aih_curated_blacklist: 7
  confidence_below_min(medium<high);total_reads_below_min(5.0<8.0): 7
  confidence_below_min(low<high);total_reads_below_min(2.0<8.0): 5
  confidence_below_min(medium<high);total_reads_below_min(4.0<8.0): 5
  confidence_below_min(low<high);total_reads_below_min(6.0<8.0): 4
  confidence_below_min(medium<high);total_reads_below_min(7.0<8.0): 4
  confidence_below_min(low<high);total_reads_below_min(5.0<8.0): 3
  confidence_below_min(low<high);total_reads_below_min(4.0<8.0): 3
  confidence_below_min(medium<high);total_reads_below_min(2.0<8.0): 2

Breakdown by confidence:
  high: 44 pass, 5 fail (total: 49)
  low: 0 pass, 119 fail (total: 119)
  medium: 0 pass, 106 fail (total: 106)
Arriba filter: 274 rows -> 44 PASS; wrote tih_rna_sample_00680_B23MVV7LT4_1.arriba.fusions.filtered.tsv and tih_rna_sample_00680_B23MVV7LT4_1.arriba.fusions.filtered_pass_only.tsv
Summary written to: tih_rna_sample_00680_B23MVV7LT4_1.arriba.fusions.filter_summary.txt