File Info

Filename
.command.out
Full Path
s3://natera-rnd-pltf-dev-nextflow-scratch-01/work/9b/027b7c7c3170a1395d667f586add76/.command.out
Size
15.4 KB
Attempt
Analyzing demux output from: merged
Loading Demultiplex_Stats.csv from: merged/Reports/Demultiplex_Stats.csv
Loaded 392 rows from Demultiplex_Stats.csv

================================================================================
1. % UNDETERMINED PER LANE
================================================================================
Undetermined Summary per Lane:
      %_Undetermined  Undetermined_Reads  Total_Reads
Lane                                                 
1               4.66           201657180   4327821958
2               4.76           204854255   4304734692
3               4.83           209169038   4332980005
4               5.02           214139561   4267817260
5               5.28           224463395   4250454746
6               5.31           224448301   4229151809
7               5.32           227677607   4276187445
8               5.55           234654678   4228210849

================================================================================
2. SAMPLES WITH <1000000 READS (NON-NTC)
================================================================================
No samples found with <1000000 reads

================================================================================
3. NTC SAMPLES WITH >2000000 READS
================================================================================
Found 2 NTC samples with >2000000 reads:
                    SampleID                  Index  # Reads
0  NTC_0001_0001_23KKJ7LT4_1  AGGCAATCGC-ATGAGTCTGT  6189071
1  NTC_0001_0001_23KKJ7LT4_2  GCATCCTACT-GACATCGCGA  5082195

================================================================================
4. TOP UNKNOWN BARCODES (>0.05% OF LANE READS)
================================================================================
Loading Top_Unknown_Barcodes.csv from: merged/Reports/Top_Unknown_Barcodes.csv

Lane 1 - Found 14 barcodes with >0.05% of lane reads:
           index      index2   # Reads  Percentage_of_Lane  Percentage_of_Total
7001  CCAGTGCACT  GGGGGGGGGG  17071524              0.3945               0.0499
7002  TTGGATTGTC  GGGGGGGGGG   9450316              0.2184               0.0276
7003  AATTGGCACA  GGGGGGGGGG   6591205              0.1523               0.0193
7004  TGCAACACTA  GGGGGGGGGG   6052821              0.1399               0.0177
7005  TCGCATGACA  GGGGGGGGGG   4657991              0.1076               0.0136
7006  GAAGCAAGCG  GGGGGGGGGG   4287288              0.0991               0.0125
7007  ACAATAGCAC  GGGGGGGGGG   3821687              0.0883               0.0112
7008  CCACCTGCTT  GGGGGGGGGG   3593237              0.0830               0.0105
7009  GTACGCATCG  GGGGGGGGGG   3517495              0.0813               0.0103
7010  CGTACTTAGA  GGGGGGGGGG   3034993              0.0701               0.0089
7011  GATCTGTATG  GGGGGGGGGG   2345695              0.0542               0.0069
7012  TTACGGACGC  GGGGGGGGGG   2312243              0.0534               0.0068
7013  ACTTCCGTTC  GGGGGGGGGG   2254874              0.0521               0.0066
7014  CATCAGGCGT  GGGGGGGGGG   2216465              0.0512               0.0065

Lane 2 - Found 15 barcodes with >0.05% of lane reads:
           index      index2   # Reads  Percentage_of_Lane  Percentage_of_Total
1000  CCAGTGCACT  GGGGGGGGGG  15691485              0.3645               0.0459
1001  TTGGATTGTC  GGGGGGGGGG   8798536              0.2044               0.0257
1002  AATTGGCACA  GGGGGGGGGG   6256110              0.1453               0.0183
1003  TGCAACACTA  GGGGGGGGGG   5828771              0.1354               0.0170
1004  TCGCATGACA  GGGGGGGGGG   4772549              0.1109               0.0139
1005  GAAGCAAGCG  GGGGGGGGGG   3884918              0.0902               0.0114
1006  ACAATAGCAC  GGGGGGGGGG   3704982              0.0861               0.0108
1007  CCACCTGCTT  GGGGGGGGGG   3698399              0.0859               0.0108
1008  GTACGCATCG  GGGGGGGGGG   3399116              0.0790               0.0099
1009  CGTACTTAGA  GGGGGGGGGG   2858804              0.0664               0.0084
1010  GATCTGTATG  GGGGGGGGGG   2495807              0.0580               0.0073
1011  TTACGGACGC  GGGGGGGGGG   2429654              0.0564               0.0071
1012  ACTTCCGTTC  GGGGGGGGGG   2324597              0.0540               0.0068
1013  AGTACAACTG  GGGGGGGGGG   2252124              0.0523               0.0066
1014  CTACAAGTTC  GGGGGGGGGG   2158134              0.0501               0.0063

Lane 3 - Found 15 barcodes with >0.05% of lane reads:
           index      index2   # Reads  Percentage_of_Lane  Percentage_of_Total
6001  CCAGTGCACT  GGGGGGGGGG  15180901              0.3504               0.0444
6002  TTGGATTGTC  GGGGGGGGGG   8574303              0.1979               0.0251
6003  AATTGGCACA  GGGGGGGGGG   6180787              0.1426               0.0181
6004  TGCAACACTA  GGGGGGGGGG   5881459              0.1357               0.0172
6005  TCGCATGACA  GGGGGGGGGG   4950297              0.1142               0.0145
6006  GAAGCAAGCG  GGGGGGGGGG   3987420              0.0920               0.0117
6007  CCACCTGCTT  GGGGGGGGGG   3890082              0.0898               0.0114
6008  ACAATAGCAC  GGGGGGGGGG   3790102              0.0875               0.0111
6009  GTACGCATCG  GGGGGGGGGG   3531683              0.0815               0.0103
6010  CGTACTTAGA  GGGGGGGGGG   3094222              0.0714               0.0090
6011  GATCTGTATG  GGGGGGGGGG   2591359              0.0598               0.0076
6012  TTACGGACGC  GGGGGGGGGG   2511405              0.0580               0.0073
6013  ACTTCCGTTC  GGGGGGGGGG   2445214              0.0564               0.0071
6014  AGTACAACTG  GGGGGGGGGG   2394711              0.0553               0.0070
6015  CTACAAGTTC  GGGGGGGGGG   2273212              0.0525               0.0066

Lane 4 - Found 18 barcodes with >0.05% of lane reads:
           index      index2   # Reads  Percentage_of_Lane  Percentage_of_Total
3000  CCAGTGCACT  GGGGGGGGGG  14615746              0.3425               0.0427
3001  TTGGATTGTC  GGGGGGGGGG   8311691              0.1948               0.0243
3002  AATTGGCACA  GGGGGGGGGG   6220867              0.1458               0.0182
3003  TGCAACACTA  GGGGGGGGGG   6095722              0.1428               0.0178
3004  TCGCATGACA  GGGGGGGGGG   5016570              0.1175               0.0147
3005  GAAGCAAGCG  GGGGGGGGGG   4337469              0.1016               0.0127
3006  CCACCTGCTT  GGGGGGGGGG   4094555              0.0959               0.0120
3007  ACAATAGCAC  GGGGGGGGGG   3829519              0.0897               0.0112
3008  GTACGCATCG  GGGGGGGGGG   3712787              0.0870               0.0109
3009  CGTACTTAGA  GGGGGGGGGG   3433570              0.0805               0.0100
3010  GATCTGTATG  GGGGGGGGGG   2995399              0.0702               0.0088
3011  ACTTCCGTTC  GGGGGGGGGG   2723886              0.0638               0.0080
3012  TTACGGACGC  GGGGGGGGGG   2714440              0.0636               0.0079
3013  AGTACAACTG  GGGGGGGGGG   2664015              0.0624               0.0078
3014  CTACAAGTTC  GGGGGGGGGG   2471397              0.0579               0.0072
3015  ATAGGCAGTG  GGGGGGGGGG   2264720              0.0531               0.0066
3016  TCAATCTAGC  GGGGGGGGGG   2260632              0.0530               0.0066
3017  GATGCTAGAA  GGGGGGGGGG   2210396              0.0518               0.0065

Lane 5 - Found 19 barcodes with >0.05% of lane reads:
           index      index2  # Reads  Percentage_of_Lane  Percentage_of_Total
2000  CTCACCAGTT  GGGGGGGGGG  9482600              0.2231               0.0277
2001  AATAGACTGC  GGGGGGGGGG  8739035              0.2056               0.0255
2002  TAGAAGATCG  GGGGGGGGGG  7612531              0.1791               0.0222
2003  AGTCCAGCGT  GGGGGGGGGG  7336649              0.1726               0.0214
2004  AGGACGGACA  GGGGGGGGGG  7140315              0.1680               0.0209
2005  CGGCATATAC  GGGGGGGGGG  4696827              0.1105               0.0137
2006  CAACGTTGAC  GGGGGGGGGG  4332297              0.1019               0.0127
2007  CATCACCTAA  GGGGGGGGGG  3703435              0.0871               0.0108
2008  CCTGGAATTA  GGGGGGGGGG  3293110              0.0775               0.0096
2009  ACGGTCGCAT  CGTCATCGAA  3259393              0.0767               0.0095
2010  CCTATGTGTA  GGGGGGGGGG  3118628              0.0734               0.0091
2011  GCGCGGTTAA  GGGGGGGGGG  2969540              0.0699               0.0087
2012  GCGAAGTAGG  CAGGCCATGT  2885608              0.0679               0.0084
2013  GCGACTCGTA  GGGGGGGGGG  2876524              0.0677               0.0084
2014  GCGCGGTTAA  GTACTCTCTA  2851901              0.0671               0.0083
2015  GCGATGGAAG  GGGGGGGGGG  2763468              0.0650               0.0081
2016  ACGGTCGCAT  AAGCTATAGC  2747653              0.0646               0.0080
2017  CACGAGTGTC  GGGGGGGGGG  2679571              0.0630               0.0078
2018  ACAGAGGCGT  GGGGGGGGGG  2389090              0.0562               0.0070

Lane 6 - Found 19 barcodes with >0.05% of lane reads:
           index      index2  # Reads  Percentage_of_Lane  Percentage_of_Total
5000  CTCACCAGTT  GGGGGGGGGG  9976890              0.2359               0.0292
5001  AATAGACTGC  GGGGGGGGGG  8859001              0.2095               0.0259
5002  TAGAAGATCG  GGGGGGGGGG  8279894              0.1958               0.0242
5003  AGTCCAGCGT  GGGGGGGGGG  7888127              0.1865               0.0231
5004  AGGACGGACA  GGGGGGGGGG  7882113              0.1864               0.0230
5005  CGGCATATAC  GGGGGGGGGG  4700725              0.1112               0.0137
5006  CAACGTTGAC  GGGGGGGGGG  4295625              0.1016               0.0126
5007  CATCACCTAA  GGGGGGGGGG  3757044              0.0888               0.0110
5008  CCTGGAATTA  GGGGGGGGGG  3345085              0.0791               0.0098
5009  ACGGTCGCAT  CGTCATCGAA  3322547              0.0786               0.0097
5010  CCTATGTGTA  GGGGGGGGGG  2908761              0.0688               0.0085
5011  GCGACTCGTA  GGGGGGGGGG  2862085              0.0677               0.0084
5012  GCGCGGTTAA  GTACTCTCTA  2842978              0.0672               0.0083
5013  GCGCGGTTAA  GGGGGGGGGG  2832696              0.0670               0.0083
5014  GCGAAGTAGG  CAGGCCATGT  2827767              0.0669               0.0083
5015  ACGGTCGCAT  AAGCTATAGC  2787528              0.0659               0.0081
5016  GCGATGGAAG  GGGGGGGGGG  2677435              0.0633               0.0078
5017  CACGAGTGTC  GGGGGGGGGG  2521842              0.0596               0.0074
5018  ACAGAGGCGT  GGGGGGGGGG  2308460              0.0546               0.0067

Lane 7 - Found 19 barcodes with >0.05% of lane reads:
           index      index2   # Reads  Percentage_of_Lane  Percentage_of_Total
4000  CTCACCAGTT  GGGGGGGGGG  10273297              0.2402               0.0300
4001  AATAGACTGC  GGGGGGGGGG   9223699              0.2157               0.0270
4002  TAGAAGATCG  GGGGGGGGGG   8675847              0.2029               0.0254
4003  AGTCCAGCGT  GGGGGGGGGG   8261550              0.1932               0.0241
4004  AGGACGGACA  GGGGGGGGGG   8058779              0.1885               0.0236
4005  CGGCATATAC  GGGGGGGGGG   4766496              0.1115               0.0139
4006  CAACGTTGAC  GGGGGGGGGG   4356298              0.1019               0.0127
4007  CATCACCTAA  GGGGGGGGGG   3820382              0.0893               0.0112
4008  CCTGGAATTA  GGGGGGGGGG   3541234              0.0828               0.0103
4009  ACGGTCGCAT  CGTCATCGAA   3349088              0.0783               0.0098
4010  GCGACTCGTA  GGGGGGGGGG   2970326              0.0695               0.0087
4011  GCGCGGTTAA  GGGGGGGGGG   2955530              0.0691               0.0086
4012  CCTATGTGTA  GGGGGGGGGG   2933578              0.0686               0.0086
4013  GCGCGGTTAA  GTACTCTCTA   2868979              0.0671               0.0084
4014  GCGAAGTAGG  CAGGCCATGT   2868818              0.0671               0.0084
4015  GCGATGGAAG  GGGGGGGGGG   2862104              0.0669               0.0084
4016  ACGGTCGCAT  AAGCTATAGC   2806545              0.0656               0.0082
4017  CACGAGTGTC  GGGGGGGGGG   2614985              0.0612               0.0076
4018  ACAGAGGCGT  GGGGGGGGGG   2326372              0.0544               0.0068

Lane 8 - Found 19 barcodes with >0.05% of lane reads:
         index      index2   # Reads  Percentage_of_Lane  Percentage_of_Total
0   CTCACCAGTT  GGGGGGGGGG  10762895              0.2545               0.0315
1   AATAGACTGC  GGGGGGGGGG  10077705              0.2383               0.0295
2   TAGAAGATCG  GGGGGGGGGG   9043631              0.2139               0.0264
3   AGTCCAGCGT  GGGGGGGGGG   8606056              0.2035               0.0252
4   AGGACGGACA  GGGGGGGGGG   8248868              0.1951               0.0241
5   CGGCATATAC  GGGGGGGGGG   4920299              0.1164               0.0144
6   CAACGTTGAC  GGGGGGGGGG   4651706              0.1100               0.0136
7   CATCACCTAA  GGGGGGGGGG   4109300              0.0972               0.0120
8   CCTGGAATTA  GGGGGGGGGG   3652859              0.0864               0.0107
9   ACGGTCGCAT  CGTCATCGAA   3290300              0.0778               0.0096
10  CCTATGTGTA  GGGGGGGGGG   3157234              0.0747               0.0092
11  GCGACTCGTA  GGGGGGGGGG   3068052              0.0726               0.0090
12  GCGCGGTTAA  GGGGGGGGGG   3047624              0.0721               0.0089
13  GCGATGGAAG  GGGGGGGGGG   2975291              0.0704               0.0087
14  GCGCGGTTAA  GTACTCTCTA   2835885              0.0671               0.0083
15  GCGAAGTAGG  CAGGCCATGT   2832434              0.0670               0.0083
16  ACGGTCGCAT  AAGCTATAGC   2752574              0.0651               0.0080
17  CACGAGTGTC  GGGGGGGGGG   2728874              0.0645               0.0080
18  ACAGAGGCGT  GGGGGGGGGG   2403712              0.0568               0.0070

================================================================================
5. BARCODES WITH HIGH MISMATCH RATES
================================================================================
No barcodes found with >20.0% mismatch rate

================================================================================
FINAL STATUS CHECK
================================================================================
Overall % Undetermined: 5.09%
Status: 🔴 FAIL
Reason(s):
  Overall undetermined 5.09% >= 5.0%
  NTC sample NTC_0001_0001_23KKJ7LT4_1 has 6,189,071 reads > 2,000,000
  NTC sample NTC_0001_0001_23KKJ7LT4_2 has 5,082,195 reads > 2,000,000
Thresholds: <5.0% = PASS, 5.0-10.0% = WARNING, >10.0% = FAIL
NTC gate: >2,000,000 reads = FAIL

=== Creating reports in . ===
QC summary saved to: ./qc_report.csv
Detailed QC report saved to: ./qc_report_detailed.txt
Fail file created: ./samplesheet_status.fail

================================================================================
QC SUMMARY
================================================================================
                        Metric       Value
                   Total_Reads 34217358764
        Total_Samples_Analyzed          97
               Number_of_Lanes           8
   Global_Percent_Undetermined       5.09%
Lanes_Exceeding_Fail_Threshold        None
        Samples_with_Low_Reads           0
   NTC_Samples_with_High_Reads           2
  Significant_Unknown_Barcodes         138
        High_Mismatch_Barcodes           0
                  Final_Status        FAIL

================================================================================
QC Analysis completed successfully!
Flowcell Status: FAIL
Reports generated:
  - ./qc_report.csv
  - ./qc_report_detailed.txt
  - ./samplesheet_status.fail
================================================================================