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==> STAGING COMPLETE (77 inputs)

mkdir -p failed for path /.config/matplotlib: [Errno 13] Permission denied: '/.config'
Matplotlib created a temporary cache directory at /tmp/matplotlib-xvp5mywc because there was an issue with the default path (/.config/matplotlib); it is highly recommended to set the MPLCONFIGDIR environment variable to a writable directory, in particular to speed up the import of Matplotlib and to better support multiprocessing.
2026-06-03 04:41:26,870 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Load count data for processing
2026-06-03 04:41:48,372 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Data loaded
2026-06-03 04:41:48,377 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Find low probe mask, low sample mask, and 2D outlier mask. Autosomes only.
2026-06-03 04:41:48,482 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 0, outliers: 1396152
2026-06-03 04:41:53,525 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 1, outliers: 323575
2026-06-03 04:41:58,568 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 2, outliers: 50225
2026-06-03 04:42:04,234 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 3, outliers: 27880
2026-06-03 04:42:10,281 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 4, outliers: 21529
2026-06-03 04:42:16,370 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 5, outliers: 18507
2026-06-03 04:42:22,547 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 6, outliers: 17075
2026-06-03 04:42:28,601 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 7, outliers: 16380
2026-06-03 04:42:34,170 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 8, outliers: 16370
2026-06-03 04:42:39,561 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 9, outliers: 16000
2026-06-03 04:42:44,901 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 10, outliers: 16701
2026-06-03 04:42:50,201 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 11, outliers: 17767
2026-06-03 04:42:55,657 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 12, outliers: 19383
2026-06-03 04:43:00,966 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 13, outliers: 22066
2026-06-03 04:43:06,555 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 14, outliers: 25877
2026-06-03 04:43:12,195 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 15, outliers: 30690
2026-06-03 04:43:17,811 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 16, outliers: 35655
2026-06-03 04:43:23,463 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 17, outliers: 34065
2026-06-03 04:43:29,103 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 18, outliers: 14585
2026-06-03 04:43:34,806 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 19, outliers: 2058
2026-06-03 04:43:40,398 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 20, outliers: 202
2026-06-03 04:43:46,885 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 21, outliers: 69
2026-06-03 04:43:52,872 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 22, outliers: 11
2026-06-03 04:43:59,079 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 23, outliers: 1
2026-06-03 04:44:05,570 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 24, outliers: 0
2026-06-03 04:44:12,105 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Masks obtained
2026-06-03 04:44:12,105 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Correct counts based on melting temperature
2026-06-03 04:44:17,507 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Corrected counts obtained
2026-06-03 04:44:17,512 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Refind masks with melting-temperature corrected counts. Autosomes only.
2026-06-03 04:44:17,642 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 0, outliers: 1396152
2026-06-03 04:44:25,059 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 1, outliers: 318792
2026-06-03 04:44:32,512 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 2, outliers: 49802
2026-06-03 04:44:39,999 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 3, outliers: 27800
2026-06-03 04:44:47,370 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 4, outliers: 21562
2026-06-03 04:44:54,632 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 5, outliers: 18483
2026-06-03 04:45:01,558 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 6, outliers: 17013
2026-06-03 04:45:08,079 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 7, outliers: 16225
2026-06-03 04:45:13,995 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 8, outliers: 16299
2026-06-03 04:45:19,946 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 9, outliers: 16073
2026-06-03 04:45:25,963 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 10, outliers: 16663
2026-06-03 04:45:31,775 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 11, outliers: 17761
2026-06-03 04:45:37,688 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 12, outliers: 19383
2026-06-03 04:45:43,722 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 13, outliers: 22119
2026-06-03 04:45:49,797 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 14, outliers: 26041
2026-06-03 04:45:55,748 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 15, outliers: 30793
2026-06-03 04:46:02,003 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 16, outliers: 35703
2026-06-03 04:46:08,512 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 17, outliers: 33888
2026-06-03 04:46:15,123 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 18, outliers: 14354
2026-06-03 04:46:21,744 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 19, outliers: 2008
2026-06-03 04:46:28,291 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 20, outliers: 198
2026-06-03 04:46:35,344 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 21, outliers: 55
2026-06-03 04:46:41,152 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 22, outliers: 12
2026-06-03 04:46:46,978 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 23, outliers: 0
2026-06-03 04:46:52,584 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Masks obtained, from melting-temperature corrected counts
2026-06-03 04:46:52,584 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Redo melting-temperature correction with new masks
2026-06-03 04:47:41,584 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Corrected counts obtained, using second round of masks
2026-06-03 04:47:41,585 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Get effective sample size per probe from covariance of nearby probes, autosomes
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-5.249050828300506 > -41.079813407556209). You may want to try with a higher value of support_fraction (current value: 0.548).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-5.249050828300506 > -41.079813407556209). You may want to try with a higher value of support_fraction (current value: 0.548).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-5.249050828300506 > -41.079813407556209). You may want to try with a higher value of support_fraction (current value: 0.548).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-5.249050828300506 > -41.079813407556209). You may want to try with a higher value of support_fraction (current value: 0.548).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-5.249050828300506 > -41.079813407556209). You may want to try with a higher value of support_fraction (current value: 0.548).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-5.249050828300506 > -41.079813407556209). You may want to try with a higher value of support_fraction (current value: 0.548).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-5.249050828300506 > -41.079813407556209). You may want to try with a higher value of support_fraction (current value: 0.548).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-5.249050828300506 > -41.079813407556209). You may want to try with a higher value of support_fraction (current value: 0.548).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-5.249050828300506 > -41.079813407556209). You may want to try with a higher value of support_fraction (current value: 0.548).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-5.249050828300506 > -41.079813407556209). You may want to try with a higher value of support_fraction (current value: 0.548).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-5.249050828300506 > -41.079813407556209). You may want to try with a higher value of support_fraction (current value: 0.548).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-5.249050828300506 > -41.079813407556209). You may want to try with a higher value of support_fraction (current value: 0.548).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-5.249050828300506 > -41.079813407556209). You may want to try with a higher value of support_fraction (current value: 0.548).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-5.249050828300506 > -41.079813407556209). You may want to try with a higher value of support_fraction (current value: 0.548).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-5.249050828300506 > -41.079813407556209). You may want to try with a higher value of support_fraction (current value: 0.548).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-5.249050828300506 > -41.079813407556209). You may want to try with a higher value of support_fraction (current value: 0.548).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-5.249050828300506 > -41.079813407556209). You may want to try with a higher value of support_fraction (current value: 0.548).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-5.249050828300506 > -41.079813407556209). You may want to try with a higher value of support_fraction (current value: 0.548).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-86.332957845292185 > -110.555819242824271). You may want to try with a higher value of support_fraction (current value: 0.592).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-115.420458590540392 > -115.651939383292003). You may want to try with a higher value of support_fraction (current value: 0.592).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-84.452687797650995 > -117.101233120698240). You may want to try with a higher value of support_fraction (current value: 0.592).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-80.172243228556781 > -106.678804834760513). You may want to try with a higher value of support_fraction (current value: 0.606).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-80.352767316210830 > -106.943819061567680). You may want to try with a higher value of support_fraction (current value: 0.606).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-80.172243228562664 > -106.414000060193757). You may want to try with a higher value of support_fraction (current value: 0.606).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-84.764256411139343 > -148.696538924224285). You may want to try with a higher value of support_fraction (current value: 0.606).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-90.557562900685610 > -158.194654301288836). You may want to try with a higher value of support_fraction (current value: 0.606).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-90.575857024342938 > -161.539521969004937). You may want to try with a higher value of support_fraction (current value: 0.606).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-90.436923878811029 > -158.830525383316001). You may want to try with a higher value of support_fraction (current value: 0.606).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-91.802916209737973 > -117.299061176850401). You may want to try with a higher value of support_fraction (current value: 0.606).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-72.067212192034901 > -100.844077431997036). You may want to try with a higher value of support_fraction (current value: 0.586).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-72.623464935470736 > -98.684621661615665). You may want to try with a higher value of support_fraction (current value: 0.586).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-67.564182710724083 > -93.571578510422157). You may want to try with a higher value of support_fraction (current value: 0.586).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-67.360859024438241 > -93.382835059536774). You may want to try with a higher value of support_fraction (current value: 0.586).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-67.787266410680445 > -135.233085995690999). You may want to try with a higher value of support_fraction (current value: 0.580).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-68.463429944700536 > -130.769278232163089). You may want to try with a higher value of support_fraction (current value: 0.580).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-70.261930474543689 > -130.043841070945291). You may want to try with a higher value of support_fraction (current value: 0.586).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-6.496003018768631 > -43.677907078971629). You may want to try with a higher value of support_fraction (current value: 0.532).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-6.496003018768631 > -43.887810305353668). You may want to try with a higher value of support_fraction (current value: 0.532).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-6.496003018768631 > -43.887810305353668). You may want to try with a higher value of support_fraction (current value: 0.532).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-6.496003018768631 > -43.887810305353668). You may want to try with a higher value of support_fraction (current value: 0.532).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-6.496003018768631 > -43.677907078971629). You may want to try with a higher value of support_fraction (current value: 0.532).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-6.496003018768631 > -43.887810305353668). You may want to try with a higher value of support_fraction (current value: 0.532).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-6.496003018768631 > -43.887810305353668). You may want to try with a higher value of support_fraction (current value: 0.532).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-6.496003018768631 > -43.887810305353668). You may want to try with a higher value of support_fraction (current value: 0.532).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:793: UserWarning: The covariance matrix associated to your dataset is not full rank
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:793: UserWarning: The covariance matrix associated to your dataset is not full rank
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:793: UserWarning: The covariance matrix associated to your dataset is not full rank
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:793: UserWarning: The covariance matrix associated to your dataset is not full rank
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:793: UserWarning: The covariance matrix associated to your dataset is not full rank
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:793: UserWarning: The covariance matrix associated to your dataset is not full rank
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:793: UserWarning: The covariance matrix associated to your dataset is not full rank
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:793: UserWarning: The covariance matrix associated to your dataset is not full rank
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:793: UserWarning: The covariance matrix associated to your dataset is not full rank
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-8.562687938520341 > -43.776755459090076). You may want to try with a higher value of support_fraction (current value: 0.524).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-8.668359915345954 > -43.875707680040833). You may want to try with a higher value of support_fraction (current value: 0.524).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-9.631107725591690 > -44.084652671148703). You may want to try with a higher value of support_fraction (current value: 0.545).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-9.631107725591690 > -44.084652671148703). You may want to try with a higher value of support_fraction (current value: 0.545).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-9.631107725591690 > -44.084652671148703). You may want to try with a higher value of support_fraction (current value: 0.545).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-9.631107725591690 > -44.084652671148703). You may want to try with a higher value of support_fraction (current value: 0.545).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-9.631107725591690 > -44.084652671148703). You may want to try with a higher value of support_fraction (current value: 0.545).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-9.631107725591690 > -44.084652671148703). You may want to try with a higher value of support_fraction (current value: 0.545).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-9.631107725591690 > -44.084652671148703). You may want to try with a higher value of support_fraction (current value: 0.545).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-9.631107725591690 > -44.084652671148703). You may want to try with a higher value of support_fraction (current value: 0.545).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-9.631107725591690 > -44.084652671148703). You may want to try with a higher value of support_fraction (current value: 0.545).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-9.631107725591690 > -44.084652671148703). You may want to try with a higher value of support_fraction (current value: 0.545).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-152.585717158801685 > -153.654010959811586). You may want to try with a higher value of support_fraction (current value: 0.627).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-147.492702971979526 > -149.418845326292740). You may want to try with a higher value of support_fraction (current value: 0.627).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-153.897338755119478 > -155.083530618427460). You may want to try with a higher value of support_fraction (current value: 0.627).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-151.601479590889454 > -151.661158406308942). You may want to try with a higher value of support_fraction (current value: 0.627).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-199.798158923237935 > -201.062625202840451). You may want to try with a higher value of support_fraction (current value: 0.627).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-237.251806409833534 > -237.910224954399496). You may want to try with a higher value of support_fraction (current value: 0.627).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-199.706604207254060 > -200.652827111186696). You may want to try with a higher value of support_fraction (current value: 0.629).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-154.423144865042417 > -155.212210397208764). You may want to try with a higher value of support_fraction (current value: 0.629).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-153.975651613481148 > -154.916193549405989). You may want to try with a higher value of support_fraction (current value: 0.629).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-199.706604207254060 > -200.652827111186696). You may want to try with a higher value of support_fraction (current value: 0.629).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-154.423144865042417 > -155.212210397208764). You may want to try with a higher value of support_fraction (current value: 0.629).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-153.975651613481148 > -154.916193549405989). You may want to try with a higher value of support_fraction (current value: 0.629).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-199.706604207254060 > -200.652827111186696). You may want to try with a higher value of support_fraction (current value: 0.629).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-154.423144865042417 > -155.212210397208764). You may want to try with a higher value of support_fraction (current value: 0.629).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-153.975651613481148 > -154.916193549405989). You may want to try with a higher value of support_fraction (current value: 0.629).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-199.706604207254060 > -200.652827111186696). You may want to try with a higher value of support_fraction (current value: 0.629).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-154.423144865042417 > -155.212210397208764). You may want to try with a higher value of support_fraction (current value: 0.629).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-153.975651613481148 > -154.916193549405989). You may want to try with a higher value of support_fraction (current value: 0.629).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-199.706604207254060 > -200.652827111186696). You may want to try with a higher value of support_fraction (current value: 0.629).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-154.423144865042417 > -155.212210397208764). You may want to try with a higher value of support_fraction (current value: 0.629).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-153.975651613481148 > -154.916193549405989). You may want to try with a higher value of support_fraction (current value: 0.629).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-199.706604207254060 > -200.652827111186696). You may want to try with a higher value of support_fraction (current value: 0.629).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-154.423144865042417 > -155.212210397208764). You may want to try with a higher value of support_fraction (current value: 0.629).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-153.975651613481148 > -154.916193549405989). You may want to try with a higher value of support_fraction (current value: 0.629).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-199.706604207254060 > -200.652827111186696). You may want to try with a higher value of support_fraction (current value: 0.629).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-154.423144865042417 > -155.212210397208764). You may want to try with a higher value of support_fraction (current value: 0.629).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-153.975651613481148 > -154.916193549405989). You may want to try with a higher value of support_fraction (current value: 0.629).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-199.706604207254060 > -200.652827111186696). You may want to try with a higher value of support_fraction (current value: 0.629).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-154.423144865042417 > -155.212210397208764). You may want to try with a higher value of support_fraction (current value: 0.629).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-153.975651613481148 > -154.916193549405989). You may want to try with a higher value of support_fraction (current value: 0.629).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-199.706604207254060 > -200.652827111186696). You may want to try with a higher value of support_fraction (current value: 0.629).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-154.423144865042417 > -155.212210397208764). You may want to try with a higher value of support_fraction (current value: 0.629).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-153.975651613481148 > -154.916193549405989). You may want to try with a higher value of support_fraction (current value: 0.629).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-230.565476422572488 > -233.250119631795172). You may want to try with a higher value of support_fraction (current value: 0.627).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-202.662872331549153 > -203.110816679367133). You may want to try with a higher value of support_fraction (current value: 0.627).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-203.094258078161317 > -203.808751938277879). You may want to try with a higher value of support_fraction (current value: 0.627).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-227.867392991625422 > -230.454925210505905). You may want to try with a higher value of support_fraction (current value: 0.627).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-227.893455623314651 > -228.466102620264564). You may want to try with a higher value of support_fraction (current value: 0.627).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-198.739707656718224 > -198.760274616567443). You may want to try with a higher value of support_fraction (current value: 0.635).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-230.993574613531166 > -231.298036021389294). You may want to try with a higher value of support_fraction (current value: 0.635).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-169.465016158053487 > -169.484706709037141). You may want to try with a higher value of support_fraction (current value: 0.635).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-128.422518570586192 > -128.922513055495244). You may want to try with a higher value of support_fraction (current value: 0.619).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-138.808640452647353 > -139.202965930689800). You may want to try with a higher value of support_fraction (current value: 0.619).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-163.553736924484696 > -164.052685766478191). You may want to try with a higher value of support_fraction (current value: 0.619).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-76.495087264081945 > -139.394029584308385). You may want to try with a higher value of support_fraction (current value: 0.652).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-76.495087264081945 > -139.394029584308385). You may want to try with a higher value of support_fraction (current value: 0.652).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-76.495087264081945 > -139.394029584308385). You may want to try with a higher value of support_fraction (current value: 0.652).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-76.495087264081945 > -139.394029584308385). You may want to try with a higher value of support_fraction (current value: 0.652).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-76.495087264081945 > -139.394029584308385). You may want to try with a higher value of support_fraction (current value: 0.652).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:793: UserWarning: The covariance matrix associated to your dataset is not full rank
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:793: UserWarning: The covariance matrix associated to your dataset is not full rank
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:793: UserWarning: The covariance matrix associated to your dataset is not full rank
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:793: UserWarning: The covariance matrix associated to your dataset is not full rank
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:793: UserWarning: The covariance matrix associated to your dataset is not full rank
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:793: UserWarning: The covariance matrix associated to your dataset is not full rank
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:793: UserWarning: The covariance matrix associated to your dataset is not full rank
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:793: UserWarning: The covariance matrix associated to your dataset is not full rank
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:793: UserWarning: The covariance matrix associated to your dataset is not full rank
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:793: UserWarning: The covariance matrix associated to your dataset is not full rank
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-11.118755081507473 > -50.705729902427059). You may want to try with a higher value of support_fraction (current value: 0.526).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-11.545726664779387 > -50.831822422020714). You may want to try with a higher value of support_fraction (current value: 0.526).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-11.559511761947114 > -50.854168669928015). You may want to try with a higher value of support_fraction (current value: 0.526).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-11.545726664779387 > -50.831822422020714). You may want to try with a higher value of support_fraction (current value: 0.526).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-11.545726664779387 > -50.831822422020714). You may want to try with a higher value of support_fraction (current value: 0.526).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-11.545726664779387 > -50.831822422020714). You may want to try with a higher value of support_fraction (current value: 0.526).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-11.545726664779387 > -50.831822422020714). You may want to try with a higher value of support_fraction (current value: 0.526).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-11.578122256668994 > -50.882639849551225). You may want to try with a higher value of support_fraction (current value: 0.526).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-11.118755081507473 > -50.705729902427059). You may want to try with a higher value of support_fraction (current value: 0.526).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-11.545726664779387 > -50.831822422020714). You may want to try with a higher value of support_fraction (current value: 0.526).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-11.559511761947114 > -50.854168669928015). You may want to try with a higher value of support_fraction (current value: 0.526).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-11.545726664779387 > -50.831822422020714). You may want to try with a higher value of support_fraction (current value: 0.526).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-11.545726664779387 > -50.831822422020714). You may want to try with a higher value of support_fraction (current value: 0.526).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-11.545726664779387 > -50.831822422020714). You may want to try with a higher value of support_fraction (current value: 0.526).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-11.545726664779387 > -50.831822422020714). You may want to try with a higher value of support_fraction (current value: 0.526).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-11.578122256668994 > -50.882639849551225). You may want to try with a higher value of support_fraction (current value: 0.526).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-62.858129574943099 > -121.008477171088487). You may want to try with a higher value of support_fraction (current value: 0.579).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-66.395934794649776 > -67.708121184143891). You may want to try with a higher value of support_fraction (current value: 0.595).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-66.395934794649776 > -67.708121184143891). You may want to try with a higher value of support_fraction (current value: 0.595).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-66.395934794649776 > -67.708121184143891). You may want to try with a higher value of support_fraction (current value: 0.595).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-66.395934794649776 > -67.708121184143891). You may want to try with a higher value of support_fraction (current value: 0.595).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-66.395934794649776 > -67.708121184143891). You may want to try with a higher value of support_fraction (current value: 0.595).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-66.395934794649776 > -67.708121184143891). You may want to try with a higher value of support_fraction (current value: 0.595).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-69.087449738947853 > -104.927894542244616). You may want to try with a higher value of support_fraction (current value: 0.577).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-69.041021694466195 > -104.820439253539689). You may want to try with a higher value of support_fraction (current value: 0.577).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-69.087449738947853 > -104.927894542244616). You may want to try with a higher value of support_fraction (current value: 0.577).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-69.041021694466195 > -104.820439253539689). You may want to try with a higher value of support_fraction (current value: 0.577).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:793: UserWarning: The covariance matrix associated to your dataset is not full rank
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:793: UserWarning: The covariance matrix associated to your dataset is not full rank
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:793: UserWarning: The covariance matrix associated to your dataset is not full rank
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:793: UserWarning: The covariance matrix associated to your dataset is not full rank
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:793: UserWarning: The covariance matrix associated to your dataset is not full rank
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:793: UserWarning: The covariance matrix associated to your dataset is not full rank
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-122.398396919408015 > -123.644050194097161). You may want to try with a higher value of support_fraction (current value: 0.593).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-51.029926106237468 > -129.777379013448495). You may want to try with a higher value of support_fraction (current value: 0.552).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-51.029926106237468 > -129.777379013448495). You may want to try with a higher value of support_fraction (current value: 0.552).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-51.029926106237468 > -129.777379013448495). You may want to try with a higher value of support_fraction (current value: 0.552).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-51.029926106237468 > -129.777379013448495). You may want to try with a higher value of support_fraction (current value: 0.552).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-216.101417867334533 > -217.938441820561280). You may want to try with a higher value of support_fraction (current value: 0.579).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-216.101417867334533 > -217.555939354913022). You may want to try with a higher value of support_fraction (current value: 0.579).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-194.359393811959592 > -196.652224534360755). You may want to try with a higher value of support_fraction (current value: 0.579).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-216.101417867334533 > -217.132831536679475). You may want to try with a higher value of support_fraction (current value: 0.579).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-216.101417867334533 > -218.289171960239486). You may want to try with a higher value of support_fraction (current value: 0.579).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-216.101417867334533 > -217.938441820561280). You may want to try with a higher value of support_fraction (current value: 0.579).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-216.101417867334533 > -217.555939354913022). You may want to try with a higher value of support_fraction (current value: 0.579).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-194.359393811959592 > -196.652224534360755). You may want to try with a higher value of support_fraction (current value: 0.579).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-216.101417867334533 > -217.132831536679475). You may want to try with a higher value of support_fraction (current value: 0.579).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-216.101417867334533 > -218.289171960239486). You may want to try with a higher value of support_fraction (current value: 0.579).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-216.101417867334533 > -217.938441820561280). You may want to try with a higher value of support_fraction (current value: 0.579).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-216.101417867334533 > -217.555939354913022). You may want to try with a higher value of support_fraction (current value: 0.579).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-194.359393811959592 > -196.652224534360755). You may want to try with a higher value of support_fraction (current value: 0.579).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-216.101417867334533 > -217.132831536679475). You may want to try with a higher value of support_fraction (current value: 0.579).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-216.101417867334533 > -218.289171960239486). You may want to try with a higher value of support_fraction (current value: 0.579).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-216.101417867334533 > -217.938441820561280). You may want to try with a higher value of support_fraction (current value: 0.579).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-216.101417867334533 > -217.555939354913022). You may want to try with a higher value of support_fraction (current value: 0.579).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-194.359393811959592 > -196.652224534360755). You may want to try with a higher value of support_fraction (current value: 0.579).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-216.101417867334533 > -217.132831536679475). You may want to try with a higher value of support_fraction (current value: 0.579).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-216.101417867334533 > -218.289171960239486). You may want to try with a higher value of support_fraction (current value: 0.579).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-216.101417867334533 > -217.938441820561280). You may want to try with a higher value of support_fraction (current value: 0.579).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-216.101417867334533 > -217.555939354913022). You may want to try with a higher value of support_fraction (current value: 0.579).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-194.359393811959592 > -196.652224534360755). You may want to try with a higher value of support_fraction (current value: 0.579).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-216.101417867334533 > -217.132831536679475). You may want to try with a higher value of support_fraction (current value: 0.579).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-216.101417867334533 > -218.289171960239486). You may want to try with a higher value of support_fraction (current value: 0.579).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-216.101417867334533 > -217.938441820561280). You may want to try with a higher value of support_fraction (current value: 0.579).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-216.101417867334533 > -217.555939354913022). You may want to try with a higher value of support_fraction (current value: 0.579).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-194.359393811959592 > -196.652224534360755). You may want to try with a higher value of support_fraction (current value: 0.579).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-216.101417867334533 > -217.132831536679475). You may want to try with a higher value of support_fraction (current value: 0.579).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-216.101417867334533 > -218.289171960239486). You may want to try with a higher value of support_fraction (current value: 0.579).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-66.793133837862541 > -101.371949399736394). You may want to try with a higher value of support_fraction (current value: 0.580).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-65.451137164467070 > -100.304620273142262). You may want to try with a higher value of support_fraction (current value: 0.580).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-66.793133837862428 > -101.384965718467328). You may want to try with a higher value of support_fraction (current value: 0.580).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-136.601242478502229 > -182.676971476049630). You may want to try with a higher value of support_fraction (current value: 0.588).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-105.299992505832691 > -315.600290119643660). You may want to try with a higher value of support_fraction (current value: 0.580).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-105.299992505832691 > -315.600290119643660). You may want to try with a higher value of support_fraction (current value: 0.580).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-274.185039545499365 > -281.573963691241602). You may want to try with a higher value of support_fraction (current value: 0.600).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-250.592788650596901 > -290.980208927491162). You may want to try with a higher value of support_fraction (current value: 0.606).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-248.498715371898101 > -293.590543392075290). You may want to try with a higher value of support_fraction (current value: 0.606).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-247.999355046937154 > -282.944119084382976). You may want to try with a higher value of support_fraction (current value: 0.606).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-251.466187858775641 > -253.529653425472958). You may want to try with a higher value of support_fraction (current value: 0.606).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-251.466187858775641 > -253.529653425472958). You may want to try with a higher value of support_fraction (current value: 0.606).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-254.522231335438164 > -289.768741293038431). You may want to try with a higher value of support_fraction (current value: 0.606).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-248.940073335760871 > -249.695774951019615). You may want to try with a higher value of support_fraction (current value: 0.606).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-254.522231335438164 > -289.768741293038431). You may want to try with a higher value of support_fraction (current value: 0.606).
2026-06-03 04:52:05,965 - cnv_pipe.cnv_pipe.batch.ess - WARNING - Not enough samples (1) compared to nearby probes (3) for probe 20465. MinCovDet requires more samples than features.
2026-06-03 04:52:05,965 - cnv_pipe.cnv_pipe.batch.ess - WARNING - Not enough samples (1) compared to nearby probes (3) for probe 20466. MinCovDet requires more samples than features.
2026-06-03 04:52:05,966 - cnv_pipe.cnv_pipe.batch.ess - WARNING - Not enough samples (1) compared to nearby probes (3) for probe 20467. MinCovDet requires more samples than features.
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-78.511954013663555 > -78.763330311569192). You may want to try with a higher value of support_fraction (current value: 0.600).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-61.756265243398225 > -113.418681324254521). You may want to try with a higher value of support_fraction (current value: 0.605).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-61.756265243398225 > -113.418681324254521). You may want to try with a higher value of support_fraction (current value: 0.605).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-101.958160429671949 > -102.201782512329686). You may want to try with a higher value of support_fraction (current value: 0.592).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-102.089621247634312 > -103.370555093096471). You may want to try with a higher value of support_fraction (current value: 0.592).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-100.527372765483420 > -100.786883960968510). You may want to try with a higher value of support_fraction (current value: 0.592).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-131.581093426275743 > -133.246021257743593). You may want to try with a higher value of support_fraction (current value: 0.577).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-81.643612404936007 > -81.931294477351457). You may want to try with a higher value of support_fraction (current value: 0.562).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-48.423474737262993 > -170.064875535165498). You may want to try with a higher value of support_fraction (current value: 0.567).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-117.125043129206432 > -118.957624592868768). You may want to try with a higher value of support_fraction (current value: 0.592).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-117.125043129206432 > -118.957624592868768). You may want to try with a higher value of support_fraction (current value: 0.592).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-117.125043129206432 > -118.957624592868768). You may want to try with a higher value of support_fraction (current value: 0.592).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-117.125043129206432 > -118.957624592868768). You may want to try with a higher value of support_fraction (current value: 0.592).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-117.125043129206432 > -118.957624592868768). You may want to try with a higher value of support_fraction (current value: 0.592).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-117.125043129206432 > -118.957624592868768). You may want to try with a higher value of support_fraction (current value: 0.592).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-117.125043129206432 > -118.957624592868768). You may want to try with a higher value of support_fraction (current value: 0.592).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-117.125043129206432 > -118.957624592868768). You may want to try with a higher value of support_fraction (current value: 0.592).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-117.125043129206432 > -118.957624592868768). You may want to try with a higher value of support_fraction (current value: 0.592).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-117.125043129206432 > -118.957624592868768). You may want to try with a higher value of support_fraction (current value: 0.592).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-118.794481315622136 > -118.822560979154844). You may want to try with a higher value of support_fraction (current value: 0.592).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-63.749290584568840 > -96.862345323686696). You may want to try with a higher value of support_fraction (current value: 0.588).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-64.723712864204686 > -97.232954218630908). You may want to try with a higher value of support_fraction (current value: 0.588).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-64.723712864204686 > -97.232954218630908). You may want to try with a higher value of support_fraction (current value: 0.588).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-70.194947915671790 > -135.115195217922633). You may want to try with a higher value of support_fraction (current value: 0.588).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-70.182311818535169 > -71.736649412162606). You may want to try with a higher value of support_fraction (current value: 0.588).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-70.182311818535169 > -71.736649412162606). You may want to try with a higher value of support_fraction (current value: 0.588).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-70.302384057002399 > -70.437965830380094). You may want to try with a higher value of support_fraction (current value: 0.588).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-40.708752771416648 > -130.212094827087867). You may want to try with a higher value of support_fraction (current value: 0.592).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-40.708752771416648 > -130.212094827087867). You may want to try with a higher value of support_fraction (current value: 0.592).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-40.708752771416648 > -130.212094827087867). You may want to try with a higher value of support_fraction (current value: 0.592).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-40.708752771416648 > -130.212094827087867). You may want to try with a higher value of support_fraction (current value: 0.592).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-23.736311773542056 > -53.524178127778953). You may want to try with a higher value of support_fraction (current value: 0.530).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-23.736311773542056 > -53.524178127778953). You may want to try with a higher value of support_fraction (current value: 0.530).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-23.736311773542056 > -53.524178127778953). You may want to try with a higher value of support_fraction (current value: 0.530).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-23.736311773542056 > -53.524178127778953). You may want to try with a higher value of support_fraction (current value: 0.530).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-23.736311773542056 > -53.524178127778953). You may want to try with a higher value of support_fraction (current value: 0.530).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-23.736311773542056 > -53.524178127778953). You may want to try with a higher value of support_fraction (current value: 0.530).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-23.736311773542056 > -53.524178127778953). You may want to try with a higher value of support_fraction (current value: 0.530).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-23.736311773542056 > -53.524178127778953). You may want to try with a higher value of support_fraction (current value: 0.530).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-23.736311773542056 > -53.524178127778953). You may want to try with a higher value of support_fraction (current value: 0.530).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-23.736311773542056 > -53.524178127778953). You may want to try with a higher value of support_fraction (current value: 0.530).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-23.736311773542056 > -53.524178127778953). You may want to try with a higher value of support_fraction (current value: 0.530).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-23.736311773542056 > -53.524178127778953). You may want to try with a higher value of support_fraction (current value: 0.530).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-23.736311773542056 > -53.524178127778953). You may want to try with a higher value of support_fraction (current value: 0.530).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-23.736311773542056 > -53.524178127778953). You may want to try with a higher value of support_fraction (current value: 0.530).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-23.736311773542056 > -53.524178127778953). You may want to try with a higher value of support_fraction (current value: 0.530).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-23.736311773542056 > -53.524178127778953). You may want to try with a higher value of support_fraction (current value: 0.530).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-23.736311773542056 > -53.524178127778953). You may want to try with a higher value of support_fraction (current value: 0.530).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-23.736311773542056 > -53.524178127778953). You may want to try with a higher value of support_fraction (current value: 0.530).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-23.736311773542056 > -53.524178127778953). You may want to try with a higher value of support_fraction (current value: 0.530).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-23.736311773542056 > -53.524178127778953). You may want to try with a higher value of support_fraction (current value: 0.530).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-23.736311773542056 > -53.524178127778953). You may want to try with a higher value of support_fraction (current value: 0.530).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-5.412301257756912 > -40.969446635319976). You may want to try with a higher value of support_fraction (current value: 0.525).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-18.678776935977616 > -50.445338117865937). You may want to try with a higher value of support_fraction (current value: 0.583).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-18.678776935977616 > -50.445338117865937). You may want to try with a higher value of support_fraction (current value: 0.583).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-18.678776935977616 > -50.445338117865937). You may want to try with a higher value of support_fraction (current value: 0.583).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-18.678776935977616 > -50.445338117865937). You may want to try with a higher value of support_fraction (current value: 0.583).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-18.678776935977616 > -50.445338117865937). You may want to try with a higher value of support_fraction (current value: 0.583).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-18.678776935977616 > -50.445338117865937). You may want to try with a higher value of support_fraction (current value: 0.583).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-18.678776935977616 > -50.445338117865937). You may want to try with a higher value of support_fraction (current value: 0.583).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-18.678776935977616 > -50.445338117865937). You may want to try with a higher value of support_fraction (current value: 0.583).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-18.678776935977616 > -50.445338117865937). You may want to try with a higher value of support_fraction (current value: 0.583).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-6.444906790345923 > -42.771583498187333). You may want to try with a higher value of support_fraction (current value: 0.537).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-7.081061875684595 > -42.621551175112153). You may want to try with a higher value of support_fraction (current value: 0.537).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-7.081061875684595 > -42.621551175112153). You may want to try with a higher value of support_fraction (current value: 0.537).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-6.444906790345923 > -42.771583498187333). You may want to try with a higher value of support_fraction (current value: 0.537).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-6.444906790345923 > -42.771583498187333). You may want to try with a higher value of support_fraction (current value: 0.537).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-7.081061875684595 > -42.621551175112153). You may want to try with a higher value of support_fraction (current value: 0.537).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-7.081061875684595 > -42.621551175112153). You may want to try with a higher value of support_fraction (current value: 0.537).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-6.444906790345923 > -42.771583498187333). You may want to try with a higher value of support_fraction (current value: 0.537).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-34.608601610243213 > -56.243243883934980). You may want to try with a higher value of support_fraction (current value: 0.529).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-34.694276304947998 > -58.270379186349771). You may want to try with a higher value of support_fraction (current value: 0.529).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-35.078274109319331 > -56.794900850917855). You may want to try with a higher value of support_fraction (current value: 0.529).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-12.004350918798814 > -46.749711625588802). You may want to try with a higher value of support_fraction (current value: 0.534).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-12.004350918798814 > -46.749711625588802). You may want to try with a higher value of support_fraction (current value: 0.534).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-12.004350918798814 > -46.749711625588802). You may want to try with a higher value of support_fraction (current value: 0.534).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-12.004350918798814 > -46.749711625588802). You may want to try with a higher value of support_fraction (current value: 0.534).
2026-06-03 04:58:52,459 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Effective sample size obtained
2026-06-03 04:58:52,459 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Get ploidy, all chromosomes
/opt/venv/lib/python3.12/site-packages/cnv_pipe/sca/pipeline.py:302: RuntimeWarning: Mean of empty slice
/opt/venv/lib/python3.12/site-packages/cnv_pipe/sca/pipeline.py:303: RuntimeWarning: Mean of empty slice
/opt/venv/lib/python3.12/site-packages/plotnine/ggplot.py:623: PlotnineWarning: Saving 6 x 5 in image.
/opt/venv/lib/python3.12/site-packages/plotnine/ggplot.py:624: PlotnineWarning: Filename: <_io.BufferedWriter name='B2377KTLT3_1__sex_calls.png'>
2026-06-03 04:59:33,028 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Ploidy obtained
2026-06-03 04:59:33,028 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Get sample medians adjusting for ploidy and effective sample size
2026-06-03 04:59:34,253 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Sample medians obtained
2026-06-03 04:59:34,253 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Use ploidy information to get the proper masks for chrX and chrY
2026-06-03 04:59:34,253 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - 
2026-06-03 04:59:34,261 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 0, outliers: 18311
2026-06-03 04:59:34,381 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 1, outliers: 36029
2026-06-03 04:59:34,472 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 2, outliers: 3814
2026-06-03 04:59:34,595 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 3, outliers: 803
2026-06-03 04:59:34,694 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 4, outliers: 117
2026-06-03 04:59:34,798 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 5, outliers: 26
2026-06-03 04:59:34,911 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 6, outliers: 8
2026-06-03 04:59:35,019 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 7, outliers: 3
2026-06-03 04:59:35,130 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 8, outliers: 1
2026-06-03 04:59:35,256 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 9, outliers: 0
2026-06-03 04:59:35,384 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 0, outliers: 1073
2026-06-03 04:59:35,387 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 1, outliers: 1957
2026-06-03 04:59:35,391 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 2, outliers: 289
2026-06-03 04:59:35,394 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 3, outliers: 55
2026-06-03 04:59:35,397 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 4, outliers: 21
2026-06-03 04:59:35,402 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 5, outliers: 9
2026-06-03 04:59:35,405 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 6, outliers: 3
2026-06-03 04:59:35,409 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 7, outliers: 0
2026-06-03 04:59:35,413 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Masks for chrX and chrY obtained
2026-06-03 04:59:35,413 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Get effective sample size for chrX and chrY
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:793: UserWarning: The covariance matrix associated to your dataset is not full rank
2026-06-03 04:59:35,886 - cnv_pipe.cnv_pipe.batch.ess - WARNING - No valid samples remain for probe 26 after NaN filtering. Assigning default weight of 1.0.
2026-06-03 04:59:35,887 - cnv_pipe.cnv_pipe.batch.ess - WARNING - No valid samples remain for probe 27 after NaN filtering. Assigning default weight of 1.0.
2026-06-03 04:59:35,887 - cnv_pipe.cnv_pipe.batch.ess - WARNING - Not enough samples (1) compared to nearby probes (2) for probe 28. MinCovDet requires more samples than features.
2026-06-03 04:59:35,888 - cnv_pipe.cnv_pipe.batch.ess - WARNING - Not enough samples (1) compared to nearby probes (2) for probe 29. MinCovDet requires more samples than features.
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:793: UserWarning: The covariance matrix associated to your dataset is not full rank
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:793: UserWarning: The covariance matrix associated to your dataset is not full rank
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:793: UserWarning: The covariance matrix associated to your dataset is not full rank
2026-06-03 04:59:35,939 - cnv_pipe.cnv_pipe.batch.ess - WARNING - Not enough samples (1) compared to nearby probes (3) for probe 35. MinCovDet requires more samples than features.
2026-06-03 04:59:35,939 - cnv_pipe.cnv_pipe.batch.ess - WARNING - Not enough samples (1) compared to nearby probes (3) for probe 36. MinCovDet requires more samples than features.
2026-06-03 04:59:35,940 - cnv_pipe.cnv_pipe.batch.ess - WARNING - Not enough samples (1) compared to nearby probes (4) for probe 37. MinCovDet requires more samples than features.
2026-06-03 04:59:35,940 - cnv_pipe.cnv_pipe.batch.ess - WARNING - Not enough samples (1) compared to nearby probes (4) for probe 38. MinCovDet requires more samples than features.
2026-06-03 04:59:35,941 - cnv_pipe.cnv_pipe.batch.ess - WARNING - Not enough samples (1) compared to nearby probes (3) for probe 39. MinCovDet requires more samples than features.
2026-06-03 04:59:35,941 - cnv_pipe.cnv_pipe.batch.ess - WARNING - Not enough samples (1) compared to nearby probes (3) for probe 40. MinCovDet requires more samples than features.
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:793: UserWarning: The covariance matrix associated to your dataset is not full rank
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:793: UserWarning: The covariance matrix associated to your dataset is not full rank
2026-06-03 04:59:35,959 - cnv_pipe.cnv_pipe.batch.ess - WARNING - Not enough samples (1) compared to nearby probes (2) for probe 43. MinCovDet requires more samples than features.
2026-06-03 04:59:35,960 - cnv_pipe.cnv_pipe.batch.ess - WARNING - Not enough samples (1) compared to nearby probes (2) for probe 44. MinCovDet requires more samples than features.
2026-06-03 04:59:35,960 - cnv_pipe.cnv_pipe.batch.ess - WARNING - Not enough samples (1) compared to nearby probes (2) for probe 45. MinCovDet requires more samples than features.
2026-06-03 04:59:35,961 - cnv_pipe.cnv_pipe.batch.ess - WARNING - Not enough samples (1) compared to nearby probes (2) for probe 46. MinCovDet requires more samples than features.
2026-06-03 04:59:35,961 - cnv_pipe.cnv_pipe.batch.ess - WARNING - Not enough samples (1) compared to nearby probes (2) for probe 47. MinCovDet requires more samples than features.
2026-06-03 04:59:35,962 - cnv_pipe.cnv_pipe.batch.ess - WARNING - Not enough samples (1) compared to nearby probes (2) for probe 48. MinCovDet requires more samples than features.
2026-06-03 04:59:35,962 - cnv_pipe.cnv_pipe.batch.ess - WARNING - Not enough samples (1) compared to nearby probes (2) for probe 49. MinCovDet requires more samples than features.
2026-06-03 04:59:35,962 - cnv_pipe.cnv_pipe.batch.ess - WARNING - Not enough samples (1) compared to nearby probes (2) for probe 50. MinCovDet requires more samples than features.
2026-06-03 04:59:35,963 - cnv_pipe.cnv_pipe.batch.ess - WARNING - Not enough samples (1) compared to nearby probes (2) for probe 51. MinCovDet requires more samples than features.
2026-06-03 04:59:35,963 - cnv_pipe.cnv_pipe.batch.ess - WARNING - Not enough samples (1) compared to nearby probes (2) for probe 52. MinCovDet requires more samples than features.
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:793: UserWarning: The covariance matrix associated to your dataset is not full rank
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:793: UserWarning: The covariance matrix associated to your dataset is not full rank
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:793: UserWarning: The covariance matrix associated to your dataset is not full rank
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:793: UserWarning: The covariance matrix associated to your dataset is not full rank
2026-06-03 04:59:36,264 - cnv_pipe.cnv_pipe.batch.ess - WARNING - No valid samples remain for probe 77 after NaN filtering. Assigning default weight of 1.0.
2026-06-03 04:59:36,264 - cnv_pipe.cnv_pipe.batch.ess - WARNING - No valid samples remain for probe 78 after NaN filtering. Assigning default weight of 1.0.
2026-06-03 04:59:36,402 - cnv_pipe.cnv_pipe.batch.ess - WARNING - No valid samples remain for probe 93 after NaN filtering. Assigning default weight of 1.0.
2026-06-03 04:59:36,402 - cnv_pipe.cnv_pipe.batch.ess - WARNING - No valid samples remain for probe 94 after NaN filtering. Assigning default weight of 1.0.
2026-06-03 04:59:36,486 - cnv_pipe.cnv_pipe.batch.ess - WARNING - No valid samples remain for probe 106 after NaN filtering. Assigning default weight of 1.0.
2026-06-03 04:59:36,486 - cnv_pipe.cnv_pipe.batch.ess - WARNING - No valid samples remain for probe 107 after NaN filtering. Assigning default weight of 1.0.
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:793: UserWarning: The covariance matrix associated to your dataset is not full rank
2026-06-03 04:59:36,757 - cnv_pipe.cnv_pipe.batch.ess - WARNING - No valid samples remain for probe 136 after NaN filtering. Assigning default weight of 1.0.
2026-06-03 04:59:36,757 - cnv_pipe.cnv_pipe.batch.ess - WARNING - No valid samples remain for probe 137 after NaN filtering. Assigning default weight of 1.0.
2026-06-03 04:59:37,335 - cnv_pipe.cnv_pipe.batch.ess - WARNING - No valid samples remain for probe 215 after NaN filtering. Assigning default weight of 1.0.
2026-06-03 04:59:37,335 - cnv_pipe.cnv_pipe.batch.ess - WARNING - No valid samples remain for probe 216 after NaN filtering. Assigning default weight of 1.0.
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:793: UserWarning: The covariance matrix associated to your dataset is not full rank
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:793: UserWarning: The covariance matrix associated to your dataset is not full rank
2026-06-03 04:59:37,510 - cnv_pipe.cnv_pipe.batch.ess - WARNING - No valid samples remain for probe 234 after NaN filtering. Assigning default weight of 1.0.
2026-06-03 04:59:37,510 - cnv_pipe.cnv_pipe.batch.ess - WARNING - No valid samples remain for probe 235 after NaN filtering. Assigning default weight of 1.0.
2026-06-03 04:59:37,510 - cnv_pipe.cnv_pipe.batch.ess - WARNING - No valid samples remain for probe 237 after NaN filtering. Assigning default weight of 1.0.
2026-06-03 04:59:37,510 - cnv_pipe.cnv_pipe.batch.ess - WARNING - No valid samples remain for probe 238 after NaN filtering. Assigning default weight of 1.0.
2026-06-03 04:59:37,510 - cnv_pipe.cnv_pipe.batch.ess - WARNING - No valid samples remain for probe 239 after NaN filtering. Assigning default weight of 1.0.
2026-06-03 04:59:37,510 - cnv_pipe.cnv_pipe.batch.ess - WARNING - No valid samples remain for probe 240 after NaN filtering. Assigning default weight of 1.0.
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-13.169932231425303 > -46.627382780708999). You may want to try with a higher value of support_fraction (current value: 0.560).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-13.169932231425303 > -46.627382780708999). You may want to try with a higher value of support_fraction (current value: 0.560).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:793: UserWarning: The covariance matrix associated to your dataset is not full rank
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:793: UserWarning: The covariance matrix associated to your dataset is not full rank
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:793: UserWarning: The covariance matrix associated to your dataset is not full rank
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:793: UserWarning: The covariance matrix associated to your dataset is not full rank
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:793: UserWarning: The covariance matrix associated to your dataset is not full rank
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:793: UserWarning: The covariance matrix associated to your dataset is not full rank
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:793: UserWarning: The covariance matrix associated to your dataset is not full rank
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:793: UserWarning: The covariance matrix associated to your dataset is not full rank
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:793: UserWarning: The covariance matrix associated to your dataset is not full rank
2026-06-03 04:59:58,178 - cnv_pipe.cnv_pipe.batch.ess - WARNING - No valid samples remain for probe 18290 after NaN filtering. Assigning default weight of 1.0.
2026-06-03 04:59:58,178 - cnv_pipe.cnv_pipe.batch.ess - WARNING - No valid samples remain for probe 18291 after NaN filtering. Assigning default weight of 1.0.
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-72.730306620586305 > -74.697596830080698). You may want to try with a higher value of support_fraction (current value: 0.625).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-68.571427424520095 > -68.603904013203959). You may want to try with a higher value of support_fraction (current value: 0.625).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-75.951068728750244 > -76.097672203618615). You may want to try with a higher value of support_fraction (current value: 0.625).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-68.571427424520095 > -68.601964148383672). You may want to try with a higher value of support_fraction (current value: 0.625).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-71.138484162825449 > -71.146206208915743). You may want to try with a higher value of support_fraction (current value: 0.625).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-102.691581413667265 > -103.287415574222663). You may want to try with a higher value of support_fraction (current value: 0.618).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-106.072691903303067 > -108.214191758800681). You may want to try with a higher value of support_fraction (current value: 0.618).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-102.691581413667265 > -103.287415574222663). You may want to try with a higher value of support_fraction (current value: 0.618).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-106.072691903303067 > -108.214191758800681). You may want to try with a higher value of support_fraction (current value: 0.618).
2026-06-03 05:00:02,805 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Effective sample size for chrX and chrY obtained
2026-06-03 05:00:02,806 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Get the final double norm values, adjusting for ploidies
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: divide by zero encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: invalid value encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: divide by zero encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: invalid value encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: divide by zero encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: invalid value encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: divide by zero encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: invalid value encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: divide by zero encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: invalid value encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: divide by zero encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: invalid value encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: divide by zero encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: invalid value encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: divide by zero encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: invalid value encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: divide by zero encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: invalid value encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: divide by zero encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: invalid value encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: divide by zero encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: invalid value encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: divide by zero encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: invalid value encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: divide by zero encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: invalid value encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: divide by zero encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: invalid value encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: divide by zero encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: invalid value encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: divide by zero encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: invalid value encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: divide by zero encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: invalid value encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: divide by zero encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: invalid value encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: divide by zero encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: invalid value encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: divide by zero encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: invalid value encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: divide by zero encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: invalid value encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: divide by zero encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: invalid value encountered in divide
2026-06-03 05:00:03,957 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Double norm values obtained
2026-06-03 05:00:03,957 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Format and write the data for sample-probe combinations
2026-06-03 05:00:25,382 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Sample-probe data written
2026-06-03 05:00:25,383 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Sample-level metrics. Calculating, formatting, and saving
/opt/venv/lib/python3.12/site-packages/numpy/lib/_nanfunctions_impl.py:1213: RuntimeWarning: Mean of empty slice
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:316: SmallSampleWarning: One or more sample arguments is too small; all returned values will be NaN. See documentation for sample size requirements.
/opt/venv/lib/python3.12/site-packages/numpy/lib/_nanfunctions_impl.py:1997: RuntimeWarning: Degrees of freedom <= 0 for slice.
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:318: SmallSampleWarning: One or more sample arguments is too small; all returned values will be NaN. See documentation for sample size requirements.
2026-06-03 05:00:28,230 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Sample-level metrics written
2026-06-03 05:00:28,231 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Save ploidy estimates
2026-06-03 05:00:28,243 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Batch pre-processing complete