mkdir -p failed for path /.config/matplotlib: [Errno 13] Permission denied: '/.config'
Matplotlib created a temporary cache directory at /tmp/matplotlib-rb0jatho because there was an issue with the default path (/.config/matplotlib); it is highly recommended to set the MPLCONFIGDIR environment variable to a writable directory, in particular to speed up the import of Matplotlib and to better support multiprocessing.
2026-06-03 04:48:12,264 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Load count data for processing
2026-06-03 04:48:32,178 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Data loaded
2026-06-03 04:48:32,184 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Find low probe mask, low sample mask, and 2D outlier mask. Autosomes only.
2026-06-03 04:48:32,288 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 0, outliers: 1396152
2026-06-03 04:48:38,051 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 1, outliers: 924360
2026-06-03 04:48:43,108 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 2, outliers: 138896
2026-06-03 04:48:48,180 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 3, outliers: 37689
2026-06-03 04:48:53,539 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 4, outliers: 12262
2026-06-03 04:48:59,048 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 5, outliers: 4464
2026-06-03 04:49:04,795 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 6, outliers: 1743
2026-06-03 04:49:10,607 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 7, outliers: 663
2026-06-03 04:49:16,252 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 8, outliers: 268
2026-06-03 04:49:21,805 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 9, outliers: 88
2026-06-03 04:49:26,965 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 10, outliers: 34
2026-06-03 04:49:31,854 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 11, outliers: 13
2026-06-03 04:49:36,705 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 12, outliers: 6
2026-06-03 04:49:41,775 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 13, outliers: 1
2026-06-03 04:49:47,117 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 14, outliers: 0
2026-06-03 04:49:52,456 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Masks obtained
2026-06-03 04:49:52,457 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Correct counts based on melting temperature
2026-06-03 04:49:56,861 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Corrected counts obtained
2026-06-03 04:49:56,865 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Refind masks with melting-temperature corrected counts. Autosomes only.
2026-06-03 04:49:56,978 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 0, outliers: 1396152
2026-06-03 04:50:03,684 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 1, outliers: 913208
2026-06-03 04:50:09,525 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 2, outliers: 131989
2026-06-03 04:50:15,508 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 3, outliers: 34803
2026-06-03 04:50:21,385 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 4, outliers: 10810
2026-06-03 04:50:27,183 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 5, outliers: 3875
2026-06-03 04:50:33,059 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 6, outliers: 1468
2026-06-03 04:50:39,184 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 7, outliers: 533
2026-06-03 04:50:45,555 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 8, outliers: 184
2026-06-03 04:50:52,044 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 9, outliers: 71
2026-06-03 04:50:58,575 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 10, outliers: 17
2026-06-03 04:51:05,228 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 11, outliers: 3
2026-06-03 04:51:11,855 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 12, outliers: 1
2026-06-03 04:51:18,557 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 13, outliers: 0
2026-06-03 04:51:25,151 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Masks obtained, from melting-temperature corrected counts
2026-06-03 04:51:25,152 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Redo melting-temperature correction with new masks
2026-06-03 04:52:11,542 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Corrected counts obtained, using second round of masks
2026-06-03 04:52:11,542 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Get effective sample size per probe from covariance of nearby probes, autosomes
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-71.390772891442452 > -103.188059593796467). You may want to try with a higher value of support_fraction (current value: 0.597).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-81.677234219185777 > -145.992895467574641). You may want to try with a higher value of support_fraction (current value: 0.606).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-81.675566083348414 > -146.535186615802559). You may want to try with a higher value of support_fraction (current value: 0.606).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-80.187897689392926 > -147.249026627212089). You may want to try with a higher value of support_fraction (current value: 0.609).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-79.223057295794618 > -143.865681678645103). You may want to try with a higher value of support_fraction (current value: 0.609).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-81.397329003108609 > -141.657269482583843). You may want to try with a higher value of support_fraction (current value: 0.609).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-192.834817698664665 > -194.561081848133966). You may want to try with a higher value of support_fraction (current value: 0.621).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-165.316866208797904 > -168.439364117467647). You may want to try with a higher value of support_fraction (current value: 0.621).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-196.125873680085590 > -196.349840353703939). You may want to try with a higher value of support_fraction (current value: 0.621).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-194.625100038351491 > -197.180963927511868). You may want to try with a higher value of support_fraction (current value: 0.621).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-193.333611200235595 > -194.107292132889086). You may want to try with a higher value of support_fraction (current value: 0.621).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-191.532378641952050 > -191.933769777395355). You may want to try with a higher value of support_fraction (current value: 0.621).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-192.834817698664665 > -194.561081848133966). You may want to try with a higher value of support_fraction (current value: 0.621).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-165.316866208797904 > -168.439364117467647). You may want to try with a higher value of support_fraction (current value: 0.621).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-196.125873680085590 > -196.349840353703939). You may want to try with a higher value of support_fraction (current value: 0.621).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-194.625100038351491 > -197.180963927511868). You may want to try with a higher value of support_fraction (current value: 0.621).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-193.333611200235595 > -194.107292132889086). You may want to try with a higher value of support_fraction (current value: 0.621).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-191.532378641952050 > -191.933769777395355). You may want to try with a higher value of support_fraction (current value: 0.621).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-219.267142926508313 > -219.942708970941567). You may want to try with a higher value of support_fraction (current value: 0.615).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-219.123730739706332 > -220.693870413928181). You may want to try with a higher value of support_fraction (current value: 0.615).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-222.402889742247964 > -222.933827442142018). You may want to try with a higher value of support_fraction (current value: 0.615).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-219.803253931699004 > -220.098986324231902). You may want to try with a higher value of support_fraction (current value: 0.615).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-220.656920657916999 > -224.218207321290095). You may want to try with a higher value of support_fraction (current value: 0.615).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-217.152391272622111 > -218.181006457979066). You may want to try with a higher value of support_fraction (current value: 0.615).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-217.184081361823928 > -218.718171628676885). You may want to try with a higher value of support_fraction (current value: 0.615).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-216.086793175228081 > -216.807030373665128). You may want to try with a higher value of support_fraction (current value: 0.615).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-211.540423896319425 > -219.776415995014332). You may want to try with a higher value of support_fraction (current value: 0.603).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-185.725646477593045 > -213.697342871268432). You may want to try with a higher value of support_fraction (current value: 0.603).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-108.225758685112183 > -167.002003548928087). You may want to try with a higher value of support_fraction (current value: 0.588).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-12.039879592134209 > -38.343248969870473). You may want to try with a higher value of support_fraction (current value: 0.567).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-12.079767499380736 > -38.444423158673267). You may want to try with a higher value of support_fraction (current value: 0.567).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-12.039879592134209 > -38.343248969870473). You may want to try with a higher value of support_fraction (current value: 0.567).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-12.079767499380736 > -38.444423158673267). You may want to try with a higher value of support_fraction (current value: 0.567).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:793: UserWarning: The covariance matrix associated to your dataset is not full rank
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:793: UserWarning: The covariance matrix associated to your dataset is not full rank
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:793: UserWarning: The covariance matrix associated to your dataset is not full rank
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:793: UserWarning: The covariance matrix associated to your dataset is not full rank
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:793: UserWarning: The covariance matrix associated to your dataset is not full rank
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:793: UserWarning: The covariance matrix associated to your dataset is not full rank
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:793: UserWarning: The covariance matrix associated to your dataset is not full rank
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:793: UserWarning: The covariance matrix associated to your dataset is not full rank
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:793: UserWarning: The covariance matrix associated to your dataset is not full rank
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:793: UserWarning: The covariance matrix associated to your dataset is not full rank
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:793: UserWarning: The covariance matrix associated to your dataset is not full rank
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:793: UserWarning: The covariance matrix associated to your dataset is not full rank
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-152.412074704753877 > -153.454534608081445). You may want to try with a higher value of support_fraction (current value: 0.629).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-152.412074704753877 > -153.454534608081445). You may want to try with a higher value of support_fraction (current value: 0.629).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-152.412074704753877 > -153.454534608081445). You may want to try with a higher value of support_fraction (current value: 0.629).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-152.412074704753877 > -153.454534608081445). You may want to try with a higher value of support_fraction (current value: 0.629).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-152.412074704753877 > -153.454534608081445). You may want to try with a higher value of support_fraction (current value: 0.629).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-152.412074704753877 > -153.454534608081445). You may want to try with a higher value of support_fraction (current value: 0.629).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-152.412074704753877 > -153.454534608081445). You may want to try with a higher value of support_fraction (current value: 0.629).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-152.412074704753877 > -153.454534608081445). You may want to try with a higher value of support_fraction (current value: 0.629).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-152.412074704753877 > -153.454534608081445). You may want to try with a higher value of support_fraction (current value: 0.629).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-181.063350022017659 > -207.523551917535002). You may want to try with a higher value of support_fraction (current value: 0.625).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-187.462313814076396 > -188.548508191943540). You may want to try with a higher value of support_fraction (current value: 0.625).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-128.290078990149510 > -128.429210597011831). You may want to try with a higher value of support_fraction (current value: 0.625).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-122.266151448740203 > -122.960608808235691). You may want to try with a higher value of support_fraction (current value: 0.631).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-93.433116413160377 > -93.608819079289390). You may want to try with a higher value of support_fraction (current value: 0.720).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-93.433116413160377 > -93.608819079289390). You may want to try with a higher value of support_fraction (current value: 0.720).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-93.433116413160377 > -93.608819079289390). You may want to try with a higher value of support_fraction (current value: 0.720).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-93.433116413160377 > -93.608819079289390). You may want to try with a higher value of support_fraction (current value: 0.720).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-93.433116413160377 > -93.608819079289390). You may want to try with a higher value of support_fraction (current value: 0.720).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-93.433116413160377 > -93.608819079289390). You may want to try with a higher value of support_fraction (current value: 0.720).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-93.433116413160377 > -93.608819079289390). You may want to try with a higher value of support_fraction (current value: 0.720).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-93.433116413160377 > -93.608819079289390). You may want to try with a higher value of support_fraction (current value: 0.720).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-96.865956983111886 > -98.812552420672418). You may want to try with a higher value of support_fraction (current value: 0.720).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-81.550483195221574 > -81.849628010683915). You may want to try with a higher value of support_fraction (current value: 0.654).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-81.550483195219485 > -81.761406958275188). You may want to try with a higher value of support_fraction (current value: 0.654).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-83.583343059081429 > -84.418337044733335). You may want to try with a higher value of support_fraction (current value: 0.654).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-81.550483195219485 > -83.045004024282960). You may want to try with a higher value of support_fraction (current value: 0.654).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-63.811214635197111 > -96.644494747498271). You may want to try with a higher value of support_fraction (current value: 0.597).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-60.710934686136710 > -118.107930221651401). You may want to try with a higher value of support_fraction (current value: 0.582).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-60.697580506870622 > -118.244503882103544). You may want to try with a higher value of support_fraction (current value: 0.582).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-82.586695483216388 > -82.874377555668303). You may want to try with a higher value of support_fraction (current value: 0.576).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-96.410509161081308 > -130.259865686063847). You may want to try with a higher value of support_fraction (current value: 0.600).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-96.410509161081308 > -130.259865686063847). You may want to try with a higher value of support_fraction (current value: 0.600).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-96.410509161081308 > -130.259865686063847). You may want to try with a higher value of support_fraction (current value: 0.600).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-96.410509161081308 > -130.259865686063847). You may want to try with a higher value of support_fraction (current value: 0.600).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-96.410509161081308 > -130.259865686063847). You may want to try with a higher value of support_fraction (current value: 0.600).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-96.410509161081308 > -130.259865686063847). You may want to try with a higher value of support_fraction (current value: 0.600).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-96.410509161081308 > -130.259865686063847). You may want to try with a higher value of support_fraction (current value: 0.600).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-96.410509161081308 > -130.259865686063847). You may want to try with a higher value of support_fraction (current value: 0.600).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-96.410509161081308 > -130.259865686063847). You may want to try with a higher value of support_fraction (current value: 0.600).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-96.410509161081308 > -130.259865686063847). You may want to try with a higher value of support_fraction (current value: 0.600).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-47.542490963707706 > -78.080479468134484). You may want to try with a higher value of support_fraction (current value: 0.559).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-47.542490963707706 > -78.080479468134484). You may want to try with a higher value of support_fraction (current value: 0.559).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-78.595145838252336 > -83.255389257044513). You may want to try with a higher value of support_fraction (current value: 0.591).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-78.595145838252336 > -83.255389257044513). You may want to try with a higher value of support_fraction (current value: 0.591).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-7.070005157270624 > -42.451972978014332). You may want to try with a higher value of support_fraction (current value: 0.538).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-7.070005157270624 > -42.451972978014332). You may want to try with a higher value of support_fraction (current value: 0.538).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-7.070005157270624 > -42.451972978014332). You may want to try with a higher value of support_fraction (current value: 0.538).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-7.070005157270624 > -42.451972978014332). You may want to try with a higher value of support_fraction (current value: 0.538).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-7.070005157270624 > -42.451972978014332). You may want to try with a higher value of support_fraction (current value: 0.538).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-7.070005157270624 > -42.451972978014332). You may want to try with a higher value of support_fraction (current value: 0.538).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-7.070005157270624 > -42.451972978014332). You may want to try with a higher value of support_fraction (current value: 0.538).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-7.070005157270624 > -42.451972978014332). You may want to try with a higher value of support_fraction (current value: 0.538).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-7.070005157270624 > -42.451972978014332). You may want to try with a higher value of support_fraction (current value: 0.538).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-7.070005157270624 > -42.451972978014332). You may want to try with a higher value of support_fraction (current value: 0.538).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-144.439849611184513 > -147.274011645994335). You may want to try with a higher value of support_fraction (current value: 0.629).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-172.158567162053259 > -172.909637076998109). You may want to try with a higher value of support_fraction (current value: 0.661).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-172.105226830848068 > -172.191200360930708). You may want to try with a higher value of support_fraction (current value: 0.661).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-178.149286628123150 > -178.165916434609557). You may want to try with a higher value of support_fraction (current value: 0.655).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-170.032369111100991 > -170.060219062034150). You may want to try with a higher value of support_fraction (current value: 0.645).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-197.332468183253411 > -197.376893834207976). You may want to try with a higher value of support_fraction (current value: 0.662).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-192.718208127407308 > -193.330246966775718). You may want to try with a higher value of support_fraction (current value: 0.662).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-197.332468183253411 > -197.376893834207976). You may want to try with a higher value of support_fraction (current value: 0.662).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-192.718208127407308 > -193.330246966775718). You may want to try with a higher value of support_fraction (current value: 0.662).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-202.837479059862318 > -205.007220231952317). You may want to try with a higher value of support_fraction (current value: 0.642).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-202.837479059862318 > -205.007220231952317). You may want to try with a higher value of support_fraction (current value: 0.642).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-198.806586469015173 > -199.910393574561141). You may want to try with a higher value of support_fraction (current value: 0.647).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-198.806586469015173 > -199.910393574561141). You may want to try with a higher value of support_fraction (current value: 0.647).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-148.054206814130481 > -148.509274205497320). You may want to try with a higher value of support_fraction (current value: 0.647).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-119.850512020036660 > -120.725564190775160). You may want to try with a higher value of support_fraction (current value: 0.617).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-50.310393448490693 > -116.802900878016175). You may want to try with a higher value of support_fraction (current value: 0.587).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-67.497225725041517 > -123.625804614002220). You may want to try with a higher value of support_fraction (current value: 0.594).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-102.698742167544395 > -104.076859316877474). You may want to try with a higher value of support_fraction (current value: 0.600).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-102.698742167544395 > -104.076859316877474). You may want to try with a higher value of support_fraction (current value: 0.600).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-102.698742167544395 > -104.076859316877474). You may want to try with a higher value of support_fraction (current value: 0.600).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-102.698742167544395 > -104.076859316877474). You may want to try with a higher value of support_fraction (current value: 0.600).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-102.698742167544395 > -104.076859316877474). You may want to try with a higher value of support_fraction (current value: 0.600).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-102.698742167544395 > -104.076859316877474). You may want to try with a higher value of support_fraction (current value: 0.600).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-146.932928658677753 > -147.614566158606863). You may want to try with a higher value of support_fraction (current value: 0.660).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-12.430319966766792 > -48.326398905168062). You may want to try with a higher value of support_fraction (current value: 0.545).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-12.430319966766792 > -48.326398905168062). You may want to try with a higher value of support_fraction (current value: 0.545).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-12.430319966766792 > -48.326398905168062). You may want to try with a higher value of support_fraction (current value: 0.545).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-12.430319966766792 > -48.326398905168062). You may want to try with a higher value of support_fraction (current value: 0.545).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-12.430319966766792 > -48.326398905168062). You may want to try with a higher value of support_fraction (current value: 0.545).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-12.430319966766792 > -48.326398905168062). You may want to try with a higher value of support_fraction (current value: 0.545).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-12.430319966766792 > -48.326398905168062). You may want to try with a higher value of support_fraction (current value: 0.545).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-12.430319966766792 > -48.326398905168062). You may want to try with a higher value of support_fraction (current value: 0.545).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-12.430319966766792 > -48.326398905168062). You may want to try with a higher value of support_fraction (current value: 0.545).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-12.430319966766792 > -48.326398905168062). You may want to try with a higher value of support_fraction (current value: 0.545).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-12.430319966766792 > -48.326398905168062). You may want to try with a higher value of support_fraction (current value: 0.545).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-12.430319966766792 > -48.326398905168062). You may want to try with a higher value of support_fraction (current value: 0.545).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-12.430319966766792 > -48.326398905168062). You may want to try with a higher value of support_fraction (current value: 0.545).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-12.430319966766792 > -48.326398905168062). You may want to try with a higher value of support_fraction (current value: 0.545).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-12.430319966766792 > -48.326398905168062). You may want to try with a higher value of support_fraction (current value: 0.545).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-12.430319966766792 > -48.326398905168062). You may want to try with a higher value of support_fraction (current value: 0.545).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-12.430319966766792 > -48.326398905168062). You may want to try with a higher value of support_fraction (current value: 0.545).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-12.430319966766792 > -48.326398905168062). You may want to try with a higher value of support_fraction (current value: 0.545).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-12.430319966766792 > -48.326398905168062). You may want to try with a higher value of support_fraction (current value: 0.545).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-12.430319966766792 > -48.326398905168062). You may want to try with a higher value of support_fraction (current value: 0.545).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-12.430319966766792 > -48.326398905168062). You may want to try with a higher value of support_fraction (current value: 0.545).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-12.430319966766792 > -48.326398905168062). You may want to try with a higher value of support_fraction (current value: 0.545).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-75.043693237555175 > -105.051733670591062). You may want to try with a higher value of support_fraction (current value: 0.582).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-38.918810131475965 > -98.248884102958755). You may want to try with a higher value of support_fraction (current value: 0.564).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-39.993964458616048 > -100.520992917008158). You may want to try with a higher value of support_fraction (current value: 0.564).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-99.561115546057309 > -102.087566513057425). You may want to try with a higher value of support_fraction (current value: 0.578).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-36.311031868792170 > -107.384174594159362). You may want to try with a higher value of support_fraction (current value: 0.559).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-151.842148156541157 > -153.540993611969043). You may want to try with a higher value of support_fraction (current value: 0.647).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-151.038748714365965 > -151.444213822477167). You may want to try with a higher value of support_fraction (current value: 0.647).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-150.903209848543980 > -153.445024630653620). You may want to try with a higher value of support_fraction (current value: 0.647).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-151.842148156541157 > -153.540993611969043). You may want to try with a higher value of support_fraction (current value: 0.647).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-151.038748714365965 > -151.444213822477167). You may want to try with a higher value of support_fraction (current value: 0.647).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-150.903209848543980 > -153.445024630653620). You may want to try with a higher value of support_fraction (current value: 0.647).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-151.842148156541157 > -153.540993611969043). You may want to try with a higher value of support_fraction (current value: 0.647).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-151.038748714365965 > -151.444213822477167). You may want to try with a higher value of support_fraction (current value: 0.647).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-150.903209848543980 > -153.445024630653620). You may want to try with a higher value of support_fraction (current value: 0.647).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-151.842148156541157 > -153.540993611969043). You may want to try with a higher value of support_fraction (current value: 0.647).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-151.038748714365965 > -151.444213822477167). You may want to try with a higher value of support_fraction (current value: 0.647).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-150.903209848543980 > -153.445024630653620). You may want to try with a higher value of support_fraction (current value: 0.647).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-151.842148156541157 > -153.540993611969043). You may want to try with a higher value of support_fraction (current value: 0.647).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-151.038748714365965 > -151.444213822477167). You may want to try with a higher value of support_fraction (current value: 0.647).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-150.903209848543980 > -153.445024630653620). You may want to try with a higher value of support_fraction (current value: 0.647).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-151.842148156541157 > -153.540993611969043). You may want to try with a higher value of support_fraction (current value: 0.647).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-151.038748714365965 > -151.444213822477167). You may want to try with a higher value of support_fraction (current value: 0.647).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-150.903209848543980 > -153.445024630653620). You may want to try with a higher value of support_fraction (current value: 0.647).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-151.842148156541157 > -153.540993611969043). You may want to try with a higher value of support_fraction (current value: 0.647).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-151.038748714365965 > -151.444213822477167). You may want to try with a higher value of support_fraction (current value: 0.647).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-150.903209848543980 > -153.445024630653620). You may want to try with a higher value of support_fraction (current value: 0.647).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-151.842148156541157 > -153.540993611969043). You may want to try with a higher value of support_fraction (current value: 0.647).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-151.038748714365965 > -151.444213822477167). You may want to try with a higher value of support_fraction (current value: 0.647).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-150.903209848543980 > -153.445024630653620). You may want to try with a higher value of support_fraction (current value: 0.647).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-104.516714359665656 > -104.821750539534904). You may want to try with a higher value of support_fraction (current value: 0.625).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-104.516714359665656 > -104.821750539534904). You may want to try with a higher value of support_fraction (current value: 0.625).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-101.663456998935558 > -103.878074055656583). You may want to try with a higher value of support_fraction (current value: 0.650).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-104.560854898523743 > -104.743162581526192). You may want to try with a higher value of support_fraction (current value: 0.630).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-104.560854898523743 > -104.743162581526192). You may want to try with a higher value of support_fraction (current value: 0.630).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-104.560854898523743 > -104.743162581526192). You may want to try with a higher value of support_fraction (current value: 0.630).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-104.560854898523743 > -104.743162581526192). You may want to try with a higher value of support_fraction (current value: 0.630).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-104.560854898523743 > -104.743162581526192). You may want to try with a higher value of support_fraction (current value: 0.630).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-104.560854898523743 > -104.743162581526192). You may want to try with a higher value of support_fraction (current value: 0.630).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-109.507199010862848 > -112.073690518410956). You may want to try with a higher value of support_fraction (current value: 0.588).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-48.758258361796535 > -101.906829322761311). You may want to try with a higher value of support_fraction (current value: 0.569).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-148.014555869928870 > -149.246423710599373). You may want to try with a higher value of support_fraction (current value: 0.622).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-56.442272584314388 > -116.186589881966256). You may want to try with a higher value of support_fraction (current value: 0.581).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-56.408669684060634 > -115.907254155890115). You may want to try with a higher value of support_fraction (current value: 0.581).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:793: UserWarning: The covariance matrix associated to your dataset is not full rank
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:793: UserWarning: The covariance matrix associated to your dataset is not full rank
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-116.961810448628057 > -117.093777167967204). You may want to try with a higher value of support_fraction (current value: 0.617).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-116.961810448628057 > -117.093777167967204). You may want to try with a higher value of support_fraction (current value: 0.617).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-116.961810448628057 > -117.093777167967204). You may want to try with a higher value of support_fraction (current value: 0.617).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-116.961810448628057 > -117.093777167967204). You may want to try with a higher value of support_fraction (current value: 0.617).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-116.961810448628057 > -117.093777167967204). You may want to try with a higher value of support_fraction (current value: 0.617).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-116.961810448628057 > -117.093777167967204). You may want to try with a higher value of support_fraction (current value: 0.617).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-116.961810448628057 > -117.093777167967204). You may want to try with a higher value of support_fraction (current value: 0.617).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-116.961810448628057 > -117.093777167967204). You may want to try with a higher value of support_fraction (current value: 0.617).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-116.961810448628057 > -117.093777167967204). You may want to try with a higher value of support_fraction (current value: 0.617).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-116.961810448628057 > -117.093777167967204). You may want to try with a higher value of support_fraction (current value: 0.617).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-135.017934438976624 > -135.423399547086603). You may want to try with a higher value of support_fraction (current value: 0.590).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-135.017934438976624 > -135.423399547086603). You may want to try with a higher value of support_fraction (current value: 0.590).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-135.017934438976624 > -135.423399547086603). You may want to try with a higher value of support_fraction (current value: 0.590).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-135.017934438976624 > -135.423399547086603). You may want to try with a higher value of support_fraction (current value: 0.590).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-135.017934438976624 > -135.423399547086603). You may want to try with a higher value of support_fraction (current value: 0.590).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-135.017934438976624 > -135.423399547086603). You may want to try with a higher value of support_fraction (current value: 0.590).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-135.017934438976624 > -135.423399547086603). You may want to try with a higher value of support_fraction (current value: 0.590).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-135.017934438976624 > -135.423399547086603). You may want to try with a higher value of support_fraction (current value: 0.590).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-135.017934438976624 > -135.423399547086603). You may want to try with a higher value of support_fraction (current value: 0.590).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-30.354756906092174 > -57.105448884228466). You may want to try with a higher value of support_fraction (current value: 0.538).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-30.354756906092174 > -57.105448884228466). You may want to try with a higher value of support_fraction (current value: 0.538).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-28.598470307889094 > -55.510858282468831). You may want to try with a higher value of support_fraction (current value: 0.538).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-28.598470307889094 > -55.510858282468831). You may want to try with a higher value of support_fraction (current value: 0.538).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-28.598470307889094 > -55.510858282468831). You may want to try with a higher value of support_fraction (current value: 0.538).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-30.354756906092174 > -57.105448884228466). You may want to try with a higher value of support_fraction (current value: 0.538).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-30.354756906092174 > -57.105448884228466). You may want to try with a higher value of support_fraction (current value: 0.538).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-28.598470307889094 > -55.510858282468831). You may want to try with a higher value of support_fraction (current value: 0.538).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-28.598470307889094 > -55.510858282468831). You may want to try with a higher value of support_fraction (current value: 0.538).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-28.598470307889094 > -55.510858282468831). You may want to try with a higher value of support_fraction (current value: 0.538).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-90.751903766132131 > -90.755707332143402). You may want to try with a higher value of support_fraction (current value: 0.574).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-59.109857208104913 > -121.923732415196895). You may want to try with a higher value of support_fraction (current value: 0.574).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-59.109857208104913 > -121.923732415196895). You may want to try with a higher value of support_fraction (current value: 0.574).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-90.751903766132131 > -91.448854512703264). You may want to try with a higher value of support_fraction (current value: 0.574).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-90.751903766132131 > -91.448854512703264). You may want to try with a higher value of support_fraction (current value: 0.574).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-90.751903766132131 > -92.142001693263239). You may want to try with a higher value of support_fraction (current value: 0.574).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-90.751903766132131 > -92.142001693263239). You may want to try with a higher value of support_fraction (current value: 0.574).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-90.751903766132131 > -92.142001693263069). You may want to try with a higher value of support_fraction (current value: 0.574).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-90.751903766132131 > -91.448854512703349). You may want to try with a higher value of support_fraction (current value: 0.574).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-90.751903766132131 > -91.448854512703264). You may want to try with a higher value of support_fraction (current value: 0.574).
2026-06-03 05:03:38,728 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Effective sample size obtained
2026-06-03 05:03:38,728 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Get ploidy, all chromosomes
/opt/venv/lib/python3.12/site-packages/cnv_pipe/sca/pipeline.py:302: RuntimeWarning: Mean of empty slice
/opt/venv/lib/python3.12/site-packages/cnv_pipe/sca/pipeline.py:303: RuntimeWarning: Mean of empty slice
/opt/venv/lib/python3.12/site-packages/plotnine/ggplot.py:623: PlotnineWarning: Saving 6 x 5 in image.
/opt/venv/lib/python3.12/site-packages/plotnine/ggplot.py:624: PlotnineWarning: Filename: <_io.BufferedWriter name='B23H3Y2LT3_1__sex_calls.png'>
/opt/venv/lib/python3.12/site-packages/plotnine/layer.py:374: PlotnineWarning: geom_point : Removed 4 rows containing missing values.
2026-06-03 05:04:23,839 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Ploidy obtained
2026-06-03 05:04:23,839 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Get sample medians adjusting for ploidy and effective sample size
2026-06-03 05:04:25,258 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Sample medians obtained
2026-06-03 05:04:25,258 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Use ploidy information to get the proper masks for chrX and chrY
2026-06-03 05:04:25,258 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - 
2026-06-03 05:04:25,264 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 0, outliers: 73244
2026-06-03 05:04:25,370 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 1, outliers: 50968
2026-06-03 05:04:25,477 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 2, outliers: 4799
2026-06-03 05:04:25,594 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 3, outliers: 950
2026-06-03 05:04:25,703 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 4, outliers: 234
2026-06-03 05:04:25,820 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 5, outliers: 76
2026-06-03 05:04:25,933 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 6, outliers: 36
2026-06-03 05:04:26,049 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 7, outliers: 36
2026-06-03 05:04:26,175 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 8, outliers: 6
2026-06-03 05:04:26,293 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 9, outliers: 2
2026-06-03 05:04:26,413 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 10, outliers: 9
2026-06-03 05:04:26,521 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 11, outliers: 10
2026-06-03 05:04:26,641 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 12, outliers: 4
2026-06-03 05:04:26,748 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 13, outliers: 0
2026-06-03 05:04:26,867 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 0, outliers: 4292
2026-06-03 05:04:26,871 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 1, outliers: 1119
2026-06-03 05:04:26,874 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 2, outliers: 142
2026-06-03 05:04:26,876 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 3, outliers: 41
2026-06-03 05:04:26,879 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 4, outliers: 12
2026-06-03 05:04:26,882 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 5, outliers: 3
2026-06-03 05:04:26,884 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 6, outliers: 1
2026-06-03 05:04:26,887 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 7, outliers: 1
2026-06-03 05:04:26,890 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 8, outliers: 0
2026-06-03 05:04:26,893 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Masks for chrX and chrY obtained
2026-06-03 05:04:26,894 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Get effective sample size for chrX and chrY
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-10.279193843973371 > -44.123382957061182). You may want to try with a higher value of support_fraction (current value: 0.591).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-10.279193843973371 > -44.123382957061182). You may want to try with a higher value of support_fraction (current value: 0.591).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-10.279193843973371 > -44.123382957061182). You may want to try with a higher value of support_fraction (current value: 0.591).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-10.279193843973371 > -44.123382957061182). You may want to try with a higher value of support_fraction (current value: 0.591).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-10.279193843973371 > -44.123382957061182). You may want to try with a higher value of support_fraction (current value: 0.591).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-10.279193843973371 > -44.123382957061182). You may want to try with a higher value of support_fraction (current value: 0.591).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-10.279193843973371 > -44.123382957061182). You may want to try with a higher value of support_fraction (current value: 0.591).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-10.279193843973371 > -44.123382957061182). You may want to try with a higher value of support_fraction (current value: 0.591).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-10.279193843973371 > -44.123382957061182). You may want to try with a higher value of support_fraction (current value: 0.591).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-10.279193843973371 > -44.123382957061182). You may want to try with a higher value of support_fraction (current value: 0.591).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-10.279193843973371 > -44.123382957061182). You may want to try with a higher value of support_fraction (current value: 0.591).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-10.279193843973371 > -44.123382957061182). You may want to try with a higher value of support_fraction (current value: 0.591).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-10.279193843973371 > -44.123382957061182). You may want to try with a higher value of support_fraction (current value: 0.591).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-10.279193843973371 > -44.123382957061182). You may want to try with a higher value of support_fraction (current value: 0.591).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-10.279193843973371 > -44.123382957061182). You may want to try with a higher value of support_fraction (current value: 0.591).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-10.279193843973371 > -44.123382957061182). You may want to try with a higher value of support_fraction (current value: 0.591).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-10.279193843973371 > -44.123382957061182). You may want to try with a higher value of support_fraction (current value: 0.591).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-10.279193843973371 > -44.123382957061182). You may want to try with a higher value of support_fraction (current value: 0.591).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-10.279193843973371 > -44.123382957061182). You may want to try with a higher value of support_fraction (current value: 0.591).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-10.279193843973371 > -44.123382957061182). You may want to try with a higher value of support_fraction (current value: 0.591).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:793: UserWarning: The covariance matrix associated to your dataset is not full rank
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:793: UserWarning: The covariance matrix associated to your dataset is not full rank
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:793: UserWarning: The covariance matrix associated to your dataset is not full rank
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-80.469554804396296 > -80.911675151983118). You may want to try with a higher value of support_fraction (current value: 0.667).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-57.113961013637848 > -79.209990968756600). You may want to try with a higher value of support_fraction (current value: 0.667).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-55.740593602336951 > -77.523683255253687). You may want to try with a higher value of support_fraction (current value: 0.667).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-80.465192252591336 > -82.855974544009740). You may want to try with a higher value of support_fraction (current value: 0.667).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-80.469554804396296 > -80.911675151983118). You may want to try with a higher value of support_fraction (current value: 0.667).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-57.113961013637848 > -79.209990968756600). You may want to try with a higher value of support_fraction (current value: 0.667).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-55.740593602336951 > -77.523683255253687). You may want to try with a higher value of support_fraction (current value: 0.667).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-80.465192252591336 > -82.855974544009740). You may want to try with a higher value of support_fraction (current value: 0.667).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-80.469554804396296 > -80.911675151983118). You may want to try with a higher value of support_fraction (current value: 0.667).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-57.113961013637848 > -79.209990968756600). You may want to try with a higher value of support_fraction (current value: 0.667).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-55.740593602336951 > -77.523683255253687). You may want to try with a higher value of support_fraction (current value: 0.667).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-80.465192252591336 > -82.855974544009740). You may want to try with a higher value of support_fraction (current value: 0.667).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-80.469554804396296 > -80.911675151983118). You may want to try with a higher value of support_fraction (current value: 0.667).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-57.113961013637848 > -79.209990968756600). You may want to try with a higher value of support_fraction (current value: 0.667).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-55.740593602336951 > -77.523683255253687). You may want to try with a higher value of support_fraction (current value: 0.667).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-80.465192252591336 > -82.855974544009740). You may want to try with a higher value of support_fraction (current value: 0.667).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-80.469554804396296 > -80.911675151983118). You may want to try with a higher value of support_fraction (current value: 0.667).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-57.113961013637848 > -79.209990968756600). You may want to try with a higher value of support_fraction (current value: 0.667).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-55.740593602336951 > -77.523683255253687). You may want to try with a higher value of support_fraction (current value: 0.667).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-80.465192252591336 > -82.855974544009740). You may want to try with a higher value of support_fraction (current value: 0.667).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-80.469554804396296 > -80.911675151983118). You may want to try with a higher value of support_fraction (current value: 0.667).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-57.113961013637848 > -79.209990968756600). You may want to try with a higher value of support_fraction (current value: 0.667).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-55.740593602336951 > -77.523683255253687). You may want to try with a higher value of support_fraction (current value: 0.667).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-80.465192252591336 > -82.855974544009740). You may want to try with a higher value of support_fraction (current value: 0.667).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-80.469554804396296 > -80.911675151983118). You may want to try with a higher value of support_fraction (current value: 0.667).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-57.113961013637848 > -79.209990968756600). You may want to try with a higher value of support_fraction (current value: 0.667).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-55.740593602336951 > -77.523683255253687). You may want to try with a higher value of support_fraction (current value: 0.667).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-80.465192252591336 > -82.855974544009740). You may want to try with a higher value of support_fraction (current value: 0.667).
2026-06-03 05:04:56,446 - cnv_pipe.cnv_pipe.batch.ess - WARNING - Not enough samples (17) compared to nearby probes (17) for probe 252. MinCovDet requires more samples than features.
2026-06-03 05:04:56,447 - cnv_pipe.cnv_pipe.batch.ess - WARNING - Not enough samples (17) compared to nearby probes (17) for probe 253. MinCovDet requires more samples than features.
2026-06-03 05:04:56,447 - cnv_pipe.cnv_pipe.batch.ess - WARNING - Not enough samples (17) compared to nearby probes (17) for probe 254. MinCovDet requires more samples than features.
2026-06-03 05:04:57,626 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Effective sample size for chrX and chrY obtained
2026-06-03 05:04:57,626 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Get the final double norm values, adjusting for ploidies
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:239: RuntimeWarning: divide by zero encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:239: RuntimeWarning: invalid value encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: divide by zero encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: invalid value encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: divide by zero encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: invalid value encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: divide by zero encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: invalid value encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: divide by zero encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: invalid value encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: divide by zero encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: invalid value encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: divide by zero encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: invalid value encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: divide by zero encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: invalid value encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: divide by zero encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: invalid value encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: divide by zero encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: invalid value encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: divide by zero encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: invalid value encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: divide by zero encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: invalid value encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: divide by zero encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: invalid value encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: divide by zero encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: invalid value encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: divide by zero encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: invalid value encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: divide by zero encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: invalid value encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: divide by zero encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: invalid value encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: divide by zero encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: invalid value encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: divide by zero encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: invalid value encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: divide by zero encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: invalid value encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: divide by zero encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: invalid value encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: divide by zero encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: invalid value encountered in divide
2026-06-03 05:04:58,837 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Double norm values obtained
2026-06-03 05:04:58,837 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Format and write the data for sample-probe combinations
2026-06-03 05:05:21,252 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Sample-probe data written
2026-06-03 05:05:21,252 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Sample-level metrics. Calculating, formatting, and saving
/opt/venv/lib/python3.12/site-packages/numpy/lib/_nanfunctions_impl.py:1213: RuntimeWarning: Mean of empty slice
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:316: SmallSampleWarning: One or more sample arguments is too small; all returned values will be NaN. See documentation for sample size requirements.
/opt/venv/lib/python3.12/site-packages/numpy/lib/_nanfunctions_impl.py:1997: RuntimeWarning: Degrees of freedom <= 0 for slice.
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:318: SmallSampleWarning: One or more sample arguments is too small; all returned values will be NaN. See documentation for sample size requirements.
/opt/venv/lib/python3.12/site-packages/numpy/lib/_nanfunctions_impl.py:1213: RuntimeWarning: Mean of empty slice
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:316: SmallSampleWarning: One or more sample arguments is too small; all returned values will be NaN. See documentation for sample size requirements.
/opt/venv/lib/python3.12/site-packages/numpy/lib/_nanfunctions_impl.py:1997: RuntimeWarning: Degrees of freedom <= 0 for slice.
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:318: SmallSampleWarning: One or more sample arguments is too small; all returned values will be NaN. See documentation for sample size requirements.
/opt/venv/lib/python3.12/site-packages/numpy/lib/_nanfunctions_impl.py:1213: RuntimeWarning: Mean of empty slice
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:316: SmallSampleWarning: One or more sample arguments is too small; all returned values will be NaN. See documentation for sample size requirements.
/opt/venv/lib/python3.12/site-packages/numpy/lib/_nanfunctions_impl.py:1997: RuntimeWarning: Degrees of freedom <= 0 for slice.
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:318: SmallSampleWarning: One or more sample arguments is too small; all returned values will be NaN. See documentation for sample size requirements.
/opt/venv/lib/python3.12/site-packages/numpy/lib/_nanfunctions_impl.py:1213: RuntimeWarning: Mean of empty slice
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:316: SmallSampleWarning: One or more sample arguments is too small; all returned values will be NaN. See documentation for sample size requirements.
/opt/venv/lib/python3.12/site-packages/numpy/lib/_nanfunctions_impl.py:1997: RuntimeWarning: Degrees of freedom <= 0 for slice.
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:318: SmallSampleWarning: One or more sample arguments is too small; all returned values will be NaN. See documentation for sample size requirements.
2026-06-03 05:05:24,082 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Sample-level metrics written
2026-06-03 05:05:24,082 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Save ploidy estimates
2026-06-03 05:05:24,091 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Batch pre-processing complete