mkdir -p failed for path /.config/matplotlib: [Errno 13] Permission denied: '/.config'
Matplotlib created a temporary cache directory at /tmp/matplotlib-md3fxau4 because there was an issue with the default path (/.config/matplotlib); it is highly recommended to set the MPLCONFIGDIR environment variable to a writable directory, in particular to speed up the import of Matplotlib and to better support multiprocessing.
2026-06-03 04:52:13,992 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Load count data for processing
2026-06-03 04:52:35,383 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Data loaded
2026-06-03 04:52:35,391 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Find low probe mask, low sample mask, and 2D outlier mask. Autosomes only.
2026-06-03 04:52:35,489 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 0, outliers: 1396152
2026-06-03 04:52:40,868 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 1, outliers: 1146322
2026-06-03 04:52:45,941 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 2, outliers: 39098
2026-06-03 04:52:51,356 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 3, outliers: 9355
2026-06-03 04:52:57,171 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 4, outliers: 3711
2026-06-03 04:53:03,046 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 5, outliers: 1814
2026-06-03 04:53:08,954 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 6, outliers: 943
2026-06-03 04:53:14,835 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 7, outliers: 557
2026-06-03 04:53:20,862 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 8, outliers: 323
2026-06-03 04:53:26,980 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 9, outliers: 219
2026-06-03 04:53:33,047 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 10, outliers: 117
2026-06-03 04:53:39,097 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 11, outliers: 62
2026-06-03 04:53:45,057 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 12, outliers: 31
2026-06-03 04:53:51,040 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 13, outliers: 23
2026-06-03 04:53:57,122 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 14, outliers: 9
2026-06-03 04:54:03,217 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 15, outliers: 10
2026-06-03 04:54:09,283 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 16, outliers: 9
2026-06-03 04:54:15,412 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 17, outliers: 10
2026-06-03 04:54:21,619 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 18, outliers: 1
2026-06-03 04:54:27,921 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 19, outliers: 0
2026-06-03 04:54:34,324 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Masks obtained
2026-06-03 04:54:34,325 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Correct counts based on melting temperature
2026-06-03 04:54:39,469 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Corrected counts obtained
2026-06-03 04:54:39,473 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Refind masks with melting-temperature corrected counts. Autosomes only.
2026-06-03 04:54:39,607 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 0, outliers: 1396152
2026-06-03 04:54:46,675 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 1, outliers: 1142123
2026-06-03 04:54:53,483 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 2, outliers: 34291
2026-06-03 04:55:00,411 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 3, outliers: 7616
2026-06-03 04:55:07,229 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 4, outliers: 2885
2026-06-03 04:55:13,590 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 5, outliers: 1381
2026-06-03 04:55:20,061 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 6, outliers: 641
2026-06-03 04:55:26,473 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 7, outliers: 319
2026-06-03 04:55:32,913 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 8, outliers: 177
2026-06-03 04:55:39,049 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 9, outliers: 75
2026-06-03 04:55:45,145 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 10, outliers: 33
2026-06-03 04:55:51,269 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 11, outliers: 23
2026-06-03 04:55:57,357 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 12, outliers: 10
2026-06-03 04:56:03,283 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 13, outliers: 0
2026-06-03 04:56:09,489 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Masks obtained, from melting-temperature corrected counts
2026-06-03 04:56:09,490 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Redo melting-temperature correction with new masks
2026-06-03 04:57:00,094 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Corrected counts obtained, using second round of masks
2026-06-03 04:57:00,094 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Get effective sample size per probe from covariance of nearby probes, autosomes
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-8.611322636529366 > -43.727747487087619). You may want to try with a higher value of support_fraction (current value: 0.536).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-8.611322636529366 > -43.727747487087619). You may want to try with a higher value of support_fraction (current value: 0.536).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-8.611322636529366 > -43.727747487087619). You may want to try with a higher value of support_fraction (current value: 0.536).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-8.611322636529366 > -43.727747487087619). You may want to try with a higher value of support_fraction (current value: 0.536).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-8.611322636529366 > -43.727747487087619). You may want to try with a higher value of support_fraction (current value: 0.536).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-8.611322636529366 > -43.727747487087619). You may want to try with a higher value of support_fraction (current value: 0.536).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-8.611322636529366 > -43.727747487087619). You may want to try with a higher value of support_fraction (current value: 0.536).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-8.611322636529366 > -43.727747487087619). You may want to try with a higher value of support_fraction (current value: 0.536).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-8.611322636529366 > -43.727747487087619). You may want to try with a higher value of support_fraction (current value: 0.536).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-8.611322636529366 > -43.727747487087619). You may want to try with a higher value of support_fraction (current value: 0.536).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-79.514032554532704 > -180.864380661970358). You may want to try with a higher value of support_fraction (current value: 0.600).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-120.422491012913085 > -182.069875126557690). You may want to try with a higher value of support_fraction (current value: 0.592).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-101.904250349059765 > -105.345689161942261). You may want to try with a higher value of support_fraction (current value: 0.606).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-72.583085658719625 > -104.846698929757395). You may want to try with a higher value of support_fraction (current value: 0.600).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-67.612893325324052 > -97.778546413106483). You may want to try with a higher value of support_fraction (current value: 0.586).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-33.954125551672952 > -99.300846809581287). You may want to try with a higher value of support_fraction (current value: 0.551).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-33.954125551672952 > -99.300846809581287). You may want to try with a higher value of support_fraction (current value: 0.551).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-65.133780494708219 > -65.244839830780450). You may want to try with a higher value of support_fraction (current value: 0.557).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-65.133780494708219 > -65.244839830780450). You may want to try with a higher value of support_fraction (current value: 0.557).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-65.133780494708219 > -65.244839830780450). You may want to try with a higher value of support_fraction (current value: 0.557).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-65.133780494708219 > -65.244839830780450). You may want to try with a higher value of support_fraction (current value: 0.557).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-65.133780494708219 > -65.244839830780450). You may want to try with a higher value of support_fraction (current value: 0.557).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-65.133780494708219 > -65.244839830780450). You may want to try with a higher value of support_fraction (current value: 0.557).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-6.971199280477169 > -39.886078418623370). You may want to try with a higher value of support_fraction (current value: 0.529).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-6.971199280477169 > -39.886078418623370). You may want to try with a higher value of support_fraction (current value: 0.529).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-6.971199280477169 > -39.886078418623370). You may want to try with a higher value of support_fraction (current value: 0.529).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-6.971199280477169 > -39.886078418623370). You may want to try with a higher value of support_fraction (current value: 0.529).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-6.971199280477169 > -39.886078418623370). You may want to try with a higher value of support_fraction (current value: 0.529).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-6.971199280477169 > -39.886078418623370). You may want to try with a higher value of support_fraction (current value: 0.529).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-6.971199280477169 > -39.886078418623370). You may want to try with a higher value of support_fraction (current value: 0.529).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-6.971199280477169 > -39.886078418623370). You may want to try with a higher value of support_fraction (current value: 0.529).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-6.971199280477169 > -39.886078418623370). You may want to try with a higher value of support_fraction (current value: 0.529).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-6.971199280477169 > -39.886078418623370). You may want to try with a higher value of support_fraction (current value: 0.529).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-10.172939730337930 > -45.272965746025605). You may want to try with a higher value of support_fraction (current value: 0.537).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-10.172939730337930 > -45.272965746025605). You may want to try with a higher value of support_fraction (current value: 0.537).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-10.172939730337930 > -45.272965746025605). You may want to try with a higher value of support_fraction (current value: 0.537).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-10.172939730337930 > -45.272965746025605). You may want to try with a higher value of support_fraction (current value: 0.537).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-10.172939730337930 > -45.272965746025605). You may want to try with a higher value of support_fraction (current value: 0.537).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-10.172939730337930 > -45.272965746025605). You may want to try with a higher value of support_fraction (current value: 0.537).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-197.124921459964014 > -198.800631084704946). You may want to try with a higher value of support_fraction (current value: 0.650).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-139.181968022308979 > -140.914920951230130). You may want to try with a higher value of support_fraction (current value: 0.607).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-107.460690512586154 > -109.323641082662263). You may want to try with a higher value of support_fraction (current value: 0.630).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-107.460690512586154 > -109.323641082662263). You may want to try with a higher value of support_fraction (current value: 0.630).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-146.540623230844886 > -146.783697871943048). You may want to try with a higher value of support_fraction (current value: 0.630).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:793: UserWarning: The covariance matrix associated to your dataset is not full rank
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-220.875083912447508 > -223.021488443034741). You may want to try with a higher value of support_fraction (current value: 0.652).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:793: UserWarning: The covariance matrix associated to your dataset is not full rank
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-220.875083912447508 > -223.021488443034741). You may want to try with a higher value of support_fraction (current value: 0.652).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-296.156403241353473 > -297.690443225650824). You may want to try with a higher value of support_fraction (current value: 0.674).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-296.156403241353473 > -297.690443225650824). You may want to try with a higher value of support_fraction (current value: 0.674).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-412.043991962841460 > -436.969340190088644). You may want to try with a higher value of support_fraction (current value: 0.717).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-408.116726079532270 > -410.585909616659876). You may want to try with a higher value of support_fraction (current value: 0.717).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-377.401971120888334 > -435.075142058735935). You may want to try with a higher value of support_fraction (current value: 0.717).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-377.203035593587458 > -378.049854534672704). You may want to try with a higher value of support_fraction (current value: 0.717).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-436.317401412281754 > -439.133051495224947). You may want to try with a higher value of support_fraction (current value: 0.717).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-412.043991962841460 > -436.969340190088644). You may want to try with a higher value of support_fraction (current value: 0.717).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-408.116726079532270 > -410.585909616659876). You may want to try with a higher value of support_fraction (current value: 0.717).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-377.401971120888334 > -435.075142058735935). You may want to try with a higher value of support_fraction (current value: 0.717).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-377.203035593587458 > -378.049854534672704). You may want to try with a higher value of support_fraction (current value: 0.717).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-436.317401412281754 > -439.133051495224947). You may want to try with a higher value of support_fraction (current value: 0.717).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-400.582375705830259 > -402.569154273176366). You may want to try with a higher value of support_fraction (current value: 0.711).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-398.042515329045727 > -399.780744502897051). You may want to try with a higher value of support_fraction (current value: 0.711).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-399.897385205881335 > -399.920656563770308). You may want to try with a higher value of support_fraction (current value: 0.711).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-399.383931879956492 > -399.475475360174187). You may want to try with a higher value of support_fraction (current value: 0.711).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-339.048805323278430 > -342.387201803705693). You may want to try with a higher value of support_fraction (current value: 0.711).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-376.025083973573601 > -381.857511938007804). You may want to try with a higher value of support_fraction (current value: 0.722).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-377.508072621274948 > -377.864406336548882). You may want to try with a higher value of support_fraction (current value: 0.722).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-373.235108661399579 > -374.763454875438811). You may want to try with a higher value of support_fraction (current value: 0.722).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-376.025083973573601 > -381.857511938007804). You may want to try with a higher value of support_fraction (current value: 0.722).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-377.508072621274948 > -377.864406336548882). You may want to try with a higher value of support_fraction (current value: 0.722).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-373.235108661399579 > -374.763454875438811). You may want to try with a higher value of support_fraction (current value: 0.722).
2026-06-03 05:00:35,703 - cnv_pipe.cnv_pipe.batch.ess - WARNING - Not enough samples (13) compared to nearby probes (15) for probe 153220. MinCovDet requires more samples than features.
2026-06-03 05:00:35,703 - cnv_pipe.cnv_pipe.batch.ess - WARNING - Not enough samples (13) compared to nearby probes (15) for probe 153221. MinCovDet requires more samples than features.
2026-06-03 05:00:35,704 - cnv_pipe.cnv_pipe.batch.ess - WARNING - Not enough samples (13) compared to nearby probes (15) for probe 153222. MinCovDet requires more samples than features.
2026-06-03 05:00:35,704 - cnv_pipe.cnv_pipe.batch.ess - WARNING - Not enough samples (13) compared to nearby probes (15) for probe 153223. MinCovDet requires more samples than features.
2026-06-03 05:00:35,705 - cnv_pipe.cnv_pipe.batch.ess - WARNING - Not enough samples (15) compared to nearby probes (16) for probe 153224. MinCovDet requires more samples than features.
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-219.376126086079694 > -220.082035981292591). You may want to try with a higher value of support_fraction (current value: 0.833).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-219.376126086079694 > -220.082035981292591). You may want to try with a higher value of support_fraction (current value: 0.833).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-219.376126086079694 > -220.082035981292591). You may want to try with a higher value of support_fraction (current value: 0.833).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-169.028521780689630 > -169.880931100529267). You may want to try with a higher value of support_fraction (current value: 0.800).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-169.028521780689630 > -169.880931100529267). You may want to try with a higher value of support_fraction (current value: 0.800).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-157.117844537580709 > -157.803209577756007). You may want to try with a higher value of support_fraction (current value: 0.681).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-157.117844537580709 > -157.803209577756007). You may want to try with a higher value of support_fraction (current value: 0.681).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-177.695866863774398 > -178.550427426600834). You may want to try with a higher value of support_fraction (current value: 0.673).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-177.695866863774398 > -178.550427426600834). You may want to try with a higher value of support_fraction (current value: 0.673).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-177.695866863774398 > -178.550427426600834). You may want to try with a higher value of support_fraction (current value: 0.673).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-102.130195556327607 > -102.374226396296734). You may want to try with a higher value of support_fraction (current value: 0.679).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-102.130195556327607 > -102.581812874455437). You may want to try with a higher value of support_fraction (current value: 0.679).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-102.130195556327607 > -102.538331124669725). You may want to try with a higher value of support_fraction (current value: 0.679).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-102.130195556327607 > -102.191313128693395). You may want to try with a higher value of support_fraction (current value: 0.679).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-102.130195556327607 > -102.374226396296734). You may want to try with a higher value of support_fraction (current value: 0.679).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-102.130195556327607 > -102.581812874455437). You may want to try with a higher value of support_fraction (current value: 0.679).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-102.130195556327607 > -102.538331124669725). You may want to try with a higher value of support_fraction (current value: 0.679).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-102.130195556327607 > -102.191313128693395). You may want to try with a higher value of support_fraction (current value: 0.679).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-102.130195556327607 > -102.374226396296734). You may want to try with a higher value of support_fraction (current value: 0.679).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-102.130195556327607 > -102.581812874455437). You may want to try with a higher value of support_fraction (current value: 0.679).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-102.130195556327607 > -102.538331124669725). You may want to try with a higher value of support_fraction (current value: 0.679).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-102.130195556327607 > -102.191313128693395). You may want to try with a higher value of support_fraction (current value: 0.679).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-102.130195556327607 > -102.374226396296734). You may want to try with a higher value of support_fraction (current value: 0.679).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-102.130195556327607 > -102.581812874455437). You may want to try with a higher value of support_fraction (current value: 0.679).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-102.130195556327607 > -102.538331124669725). You may want to try with a higher value of support_fraction (current value: 0.679).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-102.130195556327607 > -102.191313128693395). You may want to try with a higher value of support_fraction (current value: 0.679).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-94.679355365612139 > -108.409736165076183). You may want to try with a higher value of support_fraction (current value: 0.636).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-127.604393345993472 > -130.576421452466491). You may want to try with a higher value of support_fraction (current value: 0.636).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-127.867602865474055 > -129.006480550516812). You may want to try with a higher value of support_fraction (current value: 0.636).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-94.679355365612139 > -108.409736165076183). You may want to try with a higher value of support_fraction (current value: 0.636).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-127.604393345993472 > -130.576421452466491). You may want to try with a higher value of support_fraction (current value: 0.636).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-127.867602865474055 > -129.006480550516812). You may want to try with a higher value of support_fraction (current value: 0.636).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-94.679355365612139 > -108.409736165076183). You may want to try with a higher value of support_fraction (current value: 0.636).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-127.604393345993472 > -130.576421452466491). You may want to try with a higher value of support_fraction (current value: 0.636).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-127.867602865474055 > -129.006480550516812). You may want to try with a higher value of support_fraction (current value: 0.636).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-94.679355365612139 > -108.409736165076183). You may want to try with a higher value of support_fraction (current value: 0.636).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-127.604393345993472 > -130.576421452466491). You may want to try with a higher value of support_fraction (current value: 0.636).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-127.867602865474055 > -129.006480550516812). You may want to try with a higher value of support_fraction (current value: 0.636).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-94.679355365612139 > -108.409736165076183). You may want to try with a higher value of support_fraction (current value: 0.636).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-127.604393345993472 > -130.576421452466491). You may want to try with a higher value of support_fraction (current value: 0.636).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-127.867602865474055 > -129.006480550516812). You may want to try with a higher value of support_fraction (current value: 0.636).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-141.411237122442316 > -143.177901672288215). You may want to try with a higher value of support_fraction (current value: 0.704).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-142.693708222654038 > -142.830074022726791). You may want to try with a higher value of support_fraction (current value: 0.704).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-137.865787460953953 > -139.785830260145929). You may want to try with a higher value of support_fraction (current value: 0.704).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-114.932288408970777 > -115.076962129537378). You may want to try with a higher value of support_fraction (current value: 0.704).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-247.207954100755416 > -249.058170506535589). You may want to try with a higher value of support_fraction (current value: 0.676).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-312.933564977084359 > -314.112053787270611). You may want to try with a higher value of support_fraction (current value: 0.644).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-249.384722679571041 > -253.859616987469565). You may want to try with a higher value of support_fraction (current value: 0.644).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-288.592446634247267 > -289.173968640912619). You may want to try with a higher value of support_fraction (current value: 0.652).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-299.104305096768144 > -303.362375398111851). You may want to try with a higher value of support_fraction (current value: 0.674).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-210.782766894999611 > -213.014564714616796). You may want to try with a higher value of support_fraction (current value: 0.674).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-334.101099780263382 > -338.081117463242833). You may want to try with a higher value of support_fraction (current value: 0.674).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-311.924504774711806 > -313.237346482334544). You may want to try with a higher value of support_fraction (current value: 0.681).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-280.452559073029988 > -280.950605385173162). You may want to try with a higher value of support_fraction (current value: 0.681).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-312.766265677182844 > -313.508069377972674). You may want to try with a higher value of support_fraction (current value: 0.681).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-253.011640951512049 > -253.330502912677986). You may want to try with a higher value of support_fraction (current value: 0.681).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-319.209145224743168 > -320.779118279339173). You may want to try with a higher value of support_fraction (current value: 0.702).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-383.934795183865788 > -384.730912797705855). You may want to try with a higher value of support_fraction (current value: 0.702).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-351.218537224423812 > -351.438519563457419). You may want to try with a higher value of support_fraction (current value: 0.702).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-352.711992383914321 > -354.760772857450661). You may want to try with a higher value of support_fraction (current value: 0.702).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-380.777147995312305 > -381.052785442428274). You may want to try with a higher value of support_fraction (current value: 0.702).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-292.396363682870344 > -292.497898703104113). You may want to try with a higher value of support_fraction (current value: 0.702).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-353.429423978888735 > -358.138438531424697). You may want to try with a higher value of support_fraction (current value: 0.702).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-380.650878354137546 > -380.777147995312305). You may want to try with a higher value of support_fraction (current value: 0.702).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-379.927113676995646 > -384.989562624004861). You may want to try with a higher value of support_fraction (current value: 0.702).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-352.202731752084617 > -355.285346919197991). You may want to try with a higher value of support_fraction (current value: 0.702).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-286.753727507506369 > -290.528143289304410). You may want to try with a higher value of support_fraction (current value: 0.702).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-285.699888348518527 > -286.420391979358897). You may want to try with a higher value of support_fraction (current value: 0.702).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-320.591519134893872 > -322.414496339647883). You may want to try with a higher value of support_fraction (current value: 0.702).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-317.486616639628721 > -320.077566872024533). You may want to try with a higher value of support_fraction (current value: 0.702).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-285.327088337278553 > -285.865679160035825). You may want to try with a higher value of support_fraction (current value: 0.702).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-316.449206998957436 > -318.135924842866984). You may want to try with a higher value of support_fraction (current value: 0.702).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-279.456141178504708 > -285.438306492230481). You may want to try with a higher value of support_fraction (current value: 0.702).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-310.661995213401269 > -314.772531996816383). You may want to try with a higher value of support_fraction (current value: 0.702).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-162.126173449499333 > -162.645245593341400). You may want to try with a higher value of support_fraction (current value: 0.702).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-219.436785489830527 > -221.027178109841259). You may want to try with a higher value of support_fraction (current value: 0.702).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-279.423727217704368 > -280.055399574043577). You may want to try with a higher value of support_fraction (current value: 0.702).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-216.964241450313011 > -217.714154059076208). You may want to try with a higher value of support_fraction (current value: 0.702).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-157.901823323124177 > -159.616044302071003). You may want to try with a higher value of support_fraction (current value: 0.702).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-214.530663564482467 > -216.119629347816669). You may want to try with a higher value of support_fraction (current value: 0.702).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-157.109640007979380 > -158.121700042416478). You may want to try with a higher value of support_fraction (current value: 0.702).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-184.414594099771563 > -184.505493222427958). You may want to try with a higher value of support_fraction (current value: 0.702).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-152.322716818958014 > -153.364355656330360). You may want to try with a higher value of support_fraction (current value: 0.702).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-156.952017125252553 > -157.743246541446695). You may want to try with a higher value of support_fraction (current value: 0.702).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-158.793811866460828 > -158.840459555241296). You may want to try with a higher value of support_fraction (current value: 0.702).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-182.722813298162151 > -186.445660567954405). You may want to try with a higher value of support_fraction (current value: 0.702).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-189.881227345206469 > -191.488491499556346). You may want to try with a higher value of support_fraction (current value: 0.702).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-213.200279111208090 > -214.552378461775305). You may want to try with a higher value of support_fraction (current value: 0.702).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-155.200813064090255 > -156.245503935960357). You may want to try with a higher value of support_fraction (current value: 0.702).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-243.880668167744801 > -244.928844338868203). You may want to try with a higher value of support_fraction (current value: 0.702).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-217.122775995064728 > -218.760427429124775). You may want to try with a higher value of support_fraction (current value: 0.696).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-156.404628355726203 > -157.476318466875341). You may want to try with a higher value of support_fraction (current value: 0.696).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-217.868372163228628 > -220.141806409542028). You may want to try with a higher value of support_fraction (current value: 0.696).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-217.122775995064728 > -219.800008899529900). You may want to try with a higher value of support_fraction (current value: 0.696).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-158.516650231219444 > -158.974725289597558). You may want to try with a higher value of support_fraction (current value: 0.696).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-156.460233987207175 > -157.679444937708951). You may want to try with a higher value of support_fraction (current value: 0.714).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-215.970068943491981 > -221.150286624004735). You may want to try with a higher value of support_fraction (current value: 0.714).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-154.841815598168409 > -156.855723098468729). You may want to try with a higher value of support_fraction (current value: 0.714).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-246.839143717563360 > -248.077845865289078). You may want to try with a higher value of support_fraction (current value: 0.714).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-224.826077308004272 > -226.070578006381652). You may want to try with a higher value of support_fraction (current value: 0.714).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-280.557756117784947 > -282.999253435873754). You may want to try with a higher value of support_fraction (current value: 0.714).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-280.115739057156588 > -280.709795837656770). You may want to try with a higher value of support_fraction (current value: 0.714).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-310.546689700068157 > -312.740382538921381). You may want to try with a higher value of support_fraction (current value: 0.714).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-250.658927518963850 > -251.943829704545806). You may want to try with a higher value of support_fraction (current value: 0.714).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-344.905749454762997 > -346.345308865626748). You may want to try with a higher value of support_fraction (current value: 0.714).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-345.882850060005410 > -347.208008896554929). You may want to try with a higher value of support_fraction (current value: 0.714).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-249.209557803939163 > -252.941849475106892). You may want to try with a higher value of support_fraction (current value: 0.714).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-342.555382009471657 > -348.691920478836551). You may want to try with a higher value of support_fraction (current value: 0.714).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-369.642196643550847 > -372.283358117819375). You may want to try with a higher value of support_fraction (current value: 0.688).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-312.567139669809535 > -312.786790699324797). You may want to try with a higher value of support_fraction (current value: 0.688).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-371.609509833403990 > -372.866479247173970). You may want to try with a higher value of support_fraction (current value: 0.688).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-371.609509833403990 > -372.866479247173970). You may want to try with a higher value of support_fraction (current value: 0.688).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-280.315672987815788 > -282.807415831398544). You may want to try with a higher value of support_fraction (current value: 0.688).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-371.227132636450790 > -373.572846210622401). You may want to try with a higher value of support_fraction (current value: 0.688).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-367.900779203906154 > -370.458956155029796). You may want to try with a higher value of support_fraction (current value: 0.694).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-335.826128908565067 > -338.861829923815264). You may want to try with a higher value of support_fraction (current value: 0.694).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-273.224932764434470 > -274.243190419170105). You may want to try with a higher value of support_fraction (current value: 0.694).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-250.984499589210714 > -251.126142563546807). You may want to try with a higher value of support_fraction (current value: 0.694).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-274.665061004055133 > -275.335921244779399). You may want to try with a higher value of support_fraction (current value: 0.694).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-247.313173235639226 > -255.250718852447164). You may want to try with a higher value of support_fraction (current value: 0.694).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-303.203061066418286 > -304.571019053705186). You may want to try with a higher value of support_fraction (current value: 0.694).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-219.372012508139818 > -219.617879247637461). You may want to try with a higher value of support_fraction (current value: 0.694).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-270.893305248278750 > -272.267109386696518). You may want to try with a higher value of support_fraction (current value: 0.694).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-303.203061066418286 > -304.309267958619785). You may want to try with a higher value of support_fraction (current value: 0.694).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-276.995886695728643 > -277.837992100292354). You may want to try with a higher value of support_fraction (current value: 0.694).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-273.956050196157378 > -274.455463010958056). You may want to try with a higher value of support_fraction (current value: 0.694).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-220.689473653976364 > -223.201448410809007). You may want to try with a higher value of support_fraction (current value: 0.694).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-277.482942959199249 > -277.492017764504283). You may want to try with a higher value of support_fraction (current value: 0.694).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-285.640539338940300 > -287.614078585279970). You may want to try with a higher value of support_fraction (current value: 0.708).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-286.324949078308123 > -287.714792674699197). You may want to try with a higher value of support_fraction (current value: 0.708).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-344.248537134309061 > -346.376536667424830). You may want to try with a higher value of support_fraction (current value: 0.708).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-257.622035878063514 > -258.149706413889817). You may want to try with a higher value of support_fraction (current value: 0.708).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-317.332319432453744 > -321.053568973216159). You may want to try with a higher value of support_fraction (current value: 0.708).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-403.179547515546233 > -405.862724014596040). You may want to try with a higher value of support_fraction (current value: 0.708).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-161.634070092455943 > -162.395730496800610). You may want to try with a higher value of support_fraction (current value: 0.794).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-167.160165484359396 > -167.634943038367425). You may want to try with a higher value of support_fraction (current value: 0.794).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-194.582553797776825 > -196.095147567185393). You may want to try with a higher value of support_fraction (current value: 0.794).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-171.990999451989779 > -172.188793255498126). You may want to try with a higher value of support_fraction (current value: 0.794).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-194.042978503798196 > -194.379018779526660). You may want to try with a higher value of support_fraction (current value: 0.794).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-166.996472508601869 > -167.995571978441802). You may want to try with a higher value of support_fraction (current value: 0.794).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-164.824439187510791 > -165.385835728694843). You may want to try with a higher value of support_fraction (current value: 0.794).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-166.395190665613200 > -167.566919155828714). You may want to try with a higher value of support_fraction (current value: 0.806).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-167.608999941234941 > -169.140720093175446). You may want to try with a higher value of support_fraction (current value: 0.806).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-171.161464548667936 > -171.348458951200854). You may want to try with a higher value of support_fraction (current value: 0.757).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-42.769332694510751 > -70.269897455657883). You may want to try with a higher value of support_fraction (current value: 0.562).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-16.184604027726813 > -69.023020518515438). You may want to try with a higher value of support_fraction (current value: 0.562).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-8.043411016791936 > -42.359252812868455). You may want to try with a higher value of support_fraction (current value: 0.532).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-8.043411016791936 > -42.359252812868455). You may want to try with a higher value of support_fraction (current value: 0.532).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-8.043411016791936 > -42.359252812868455). You may want to try with a higher value of support_fraction (current value: 0.532).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-8.043411016791936 > -42.359252812868455). You may want to try with a higher value of support_fraction (current value: 0.532).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-8.043411016791936 > -42.359252812868455). You may want to try with a higher value of support_fraction (current value: 0.532).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-8.043411016791936 > -42.359252812868455). You may want to try with a higher value of support_fraction (current value: 0.532).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-8.043411016791936 > -42.359252812868455). You may want to try with a higher value of support_fraction (current value: 0.532).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-8.043411016791936 > -42.359252812868455). You may want to try with a higher value of support_fraction (current value: 0.532).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-8.043411016791936 > -42.359252812868455). You may want to try with a higher value of support_fraction (current value: 0.532).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-8.043411016791936 > -42.359252812868455). You may want to try with a higher value of support_fraction (current value: 0.532).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-179.169024952815846 > -180.077017725738415). You may want to try with a higher value of support_fraction (current value: 0.586).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-179.169024952815846 > -182.792498302037103). You may want to try with a higher value of support_fraction (current value: 0.586).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-202.908091904027060 > -236.616791289338806). You may want to try with a higher value of support_fraction (current value: 0.592).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-202.908091904027060 > -234.552690785485396). You may want to try with a higher value of support_fraction (current value: 0.592).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-200.684796701704244 > -237.489052969182609). You may want to try with a higher value of support_fraction (current value: 0.592).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-200.684796701704244 > -237.489052969182609). You may want to try with a higher value of support_fraction (current value: 0.592).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-138.526883498349548 > -233.681739575778522). You may want to try with a higher value of support_fraction (current value: 0.592).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-200.684796701704244 > -237.489052969182609). You may want to try with a higher value of support_fraction (current value: 0.592).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-202.908091904027060 > -229.629107973842963). You may want to try with a higher value of support_fraction (current value: 0.592).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-88.576524451431240 > -92.402955445169283). You may want to try with a higher value of support_fraction (current value: 0.618).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-73.533934738066222 > -74.183988256020740). You may want to try with a higher value of support_fraction (current value: 0.606).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-75.588126185602519 > -138.762191384060628). You may want to try with a higher value of support_fraction (current value: 0.615).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-104.335363314610817 > -106.187634432671757). You may want to try with a higher value of support_fraction (current value: 0.615).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-104.335363314610817 > -106.187634432671757). You may want to try with a higher value of support_fraction (current value: 0.615).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-75.588126185602519 > -138.762191384060628). You may want to try with a higher value of support_fraction (current value: 0.615).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-104.335363314610817 > -106.187634432671757). You may want to try with a higher value of support_fraction (current value: 0.615).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-104.335363314610817 > -106.187634432671757). You may want to try with a higher value of support_fraction (current value: 0.615).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-75.588126185602519 > -138.762191384060628). You may want to try with a higher value of support_fraction (current value: 0.615).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-104.335363314610817 > -106.187634432671757). You may want to try with a higher value of support_fraction (current value: 0.615).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-104.335363314610817 > -106.187634432671757). You may want to try with a higher value of support_fraction (current value: 0.615).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-75.588126185602519 > -138.762191384060628). You may want to try with a higher value of support_fraction (current value: 0.615).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-104.335363314610817 > -106.187634432671757). You may want to try with a higher value of support_fraction (current value: 0.615).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-104.335363314610817 > -106.187634432671757). You may want to try with a higher value of support_fraction (current value: 0.615).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-75.588126185602519 > -138.762191384060628). You may want to try with a higher value of support_fraction (current value: 0.615).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-104.335363314610817 > -106.187634432671757). You may want to try with a higher value of support_fraction (current value: 0.615).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-104.335363314610817 > -106.187634432671757). You may want to try with a higher value of support_fraction (current value: 0.615).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-33.945596969054520 > -159.871372083412354). You may want to try with a higher value of support_fraction (current value: 0.595).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-33.945596969054520 > -159.871372083412354). You may want to try with a higher value of support_fraction (current value: 0.595).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-33.945596969054520 > -159.871372083412354). You may want to try with a higher value of support_fraction (current value: 0.595).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-12.645303725913410 > -49.456343472915933). You may want to try with a higher value of support_fraction (current value: 0.521).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-12.645303725913410 > -49.456343472915933). You may want to try with a higher value of support_fraction (current value: 0.521).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-12.645303725913410 > -49.456343472915933). You may want to try with a higher value of support_fraction (current value: 0.521).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-12.645303725913410 > -49.456343472915933). You may want to try with a higher value of support_fraction (current value: 0.521).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-11.129699526014587 > -45.446210908961220). You may want to try with a higher value of support_fraction (current value: 0.522).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-11.129699526014587 > -45.446210908961220). You may want to try with a higher value of support_fraction (current value: 0.522).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-11.129699526014587 > -45.446210908961220). You may want to try with a higher value of support_fraction (current value: 0.522).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-11.129699526014587 > -45.446210908961220). You may want to try with a higher value of support_fraction (current value: 0.522).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-11.129699526014587 > -45.446210908961220). You may want to try with a higher value of support_fraction (current value: 0.522).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-11.129699526014587 > -45.446210908961220). You may want to try with a higher value of support_fraction (current value: 0.522).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-11.129699526014587 > -45.446210908961220). You may want to try with a higher value of support_fraction (current value: 0.522).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-11.129699526014587 > -45.446210908961220). You may want to try with a higher value of support_fraction (current value: 0.522).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-11.129699526014587 > -45.446210908961220). You may want to try with a higher value of support_fraction (current value: 0.522).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-11.129699526014587 > -45.446210908961220). You may want to try with a higher value of support_fraction (current value: 0.522).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-36.424734350389755 > -59.813444071337393). You may want to try with a higher value of support_fraction (current value: 0.564).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-36.424734350389755 > -59.813444071337393). You may want to try with a higher value of support_fraction (current value: 0.564).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-36.424734350389755 > -59.813444071337393). You may want to try with a higher value of support_fraction (current value: 0.564).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-36.424734350389755 > -59.813444071337393). You may want to try with a higher value of support_fraction (current value: 0.564).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-58.794825783093493 > -87.966252477270189). You may want to try with a higher value of support_fraction (current value: 0.585).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-58.794825783093493 > -87.966252477270189). You may want to try with a higher value of support_fraction (current value: 0.585).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-26.857749330213540 > -52.936028011157376). You may want to try with a higher value of support_fraction (current value: 0.532).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-26.857749330213540 > -52.936028011157376). You may want to try with a higher value of support_fraction (current value: 0.532).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-26.857749330213540 > -52.936028011157376). You may want to try with a higher value of support_fraction (current value: 0.532).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-26.857749330213540 > -52.936028011157376). You may want to try with a higher value of support_fraction (current value: 0.532).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-26.857749330213540 > -52.936028011157376). You may want to try with a higher value of support_fraction (current value: 0.532).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-26.857749330213540 > -52.936028011157376). You may want to try with a higher value of support_fraction (current value: 0.532).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-26.857749330213540 > -52.936028011157376). You may want to try with a higher value of support_fraction (current value: 0.532).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-26.857749330213540 > -52.936028011157376). You may want to try with a higher value of support_fraction (current value: 0.532).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-26.857749330213540 > -52.936028011157376). You may want to try with a higher value of support_fraction (current value: 0.532).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-26.857749330213540 > -52.936028011157376). You may want to try with a higher value of support_fraction (current value: 0.532).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-26.857749330213540 > -52.936028011157376). You may want to try with a higher value of support_fraction (current value: 0.532).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-26.857749330213540 > -52.936028011157376). You may want to try with a higher value of support_fraction (current value: 0.532).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-26.857749330213540 > -52.936028011157376). You may want to try with a higher value of support_fraction (current value: 0.532).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-26.857749330213540 > -52.936028011157376). You may want to try with a higher value of support_fraction (current value: 0.532).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-57.339517410562266 > -57.437455585051282). You may want to try with a higher value of support_fraction (current value: 0.529).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-57.339517410562266 > -57.437455585051282). You may want to try with a higher value of support_fraction (current value: 0.529).
2026-06-03 05:08:32,484 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Effective sample size obtained
2026-06-03 05:08:32,484 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Get ploidy, all chromosomes
/opt/venv/lib/python3.12/site-packages/cnv_pipe/sca/pipeline.py:302: RuntimeWarning: Mean of empty slice
/opt/venv/lib/python3.12/site-packages/cnv_pipe/sca/pipeline.py:303: RuntimeWarning: Mean of empty slice
/opt/venv/lib/python3.12/site-packages/plotnine/ggplot.py:623: PlotnineWarning: Saving 6 x 5 in image.
/opt/venv/lib/python3.12/site-packages/plotnine/ggplot.py:624: PlotnineWarning: Filename: <_io.BufferedWriter name='B23K7JFLT3_1__sex_calls.png'>
/opt/venv/lib/python3.12/site-packages/plotnine/layer.py:374: PlotnineWarning: geom_point : Removed 1 rows containing missing values.
2026-06-03 05:09:18,500 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Ploidy obtained
2026-06-03 05:09:18,500 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Get sample medians adjusting for ploidy and effective sample size
2026-06-03 05:09:20,057 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Sample medians obtained
2026-06-03 05:09:20,058 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Use ploidy information to get the proper masks for chrX and chrY
2026-06-03 05:09:20,058 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - 
2026-06-03 05:09:20,065 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 0, outliers: 18311
2026-06-03 05:09:20,220 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 1, outliers: 52397
2026-06-03 05:09:20,359 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 2, outliers: 1927
2026-06-03 05:09:20,510 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 3, outliers: 239
2026-06-03 05:09:20,653 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 4, outliers: 49
2026-06-03 05:09:20,801 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 5, outliers: 10
2026-06-03 05:09:20,948 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 6, outliers: 5
2026-06-03 05:09:21,102 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 7, outliers: 3
2026-06-03 05:09:21,240 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 8, outliers: 0
2026-06-03 05:09:21,391 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 0, outliers: 1073
2026-06-03 05:09:21,396 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 1, outliers: 1167
2026-06-03 05:09:21,400 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 2, outliers: 137
2026-06-03 05:09:21,403 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 3, outliers: 17
2026-06-03 05:09:21,406 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 4, outliers: 8
2026-06-03 05:09:21,409 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 5, outliers: 1
2026-06-03 05:09:21,412 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 6, outliers: 2
2026-06-03 05:09:21,415 - cnv_pipe.cnv_pipe.batch.mask - INFO - Iteration 7, outliers: 0
2026-06-03 05:09:21,420 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Masks for chrX and chrY obtained
2026-06-03 05:09:21,420 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Get effective sample size for chrX and chrY
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-23.809861622080980 > -52.733418337657959). You may want to try with a higher value of support_fraction (current value: 0.576).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-23.809861622080980 > -52.733418337657959). You may want to try with a higher value of support_fraction (current value: 0.576).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-23.809861622080980 > -52.733418337657959). You may want to try with a higher value of support_fraction (current value: 0.576).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-20.180319402843946 > -50.763530128949789). You may want to try with a higher value of support_fraction (current value: 0.545).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-20.641700835827514 > -51.876250694561222). You may want to try with a higher value of support_fraction (current value: 0.545).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-20.180319402843946 > -50.763530128949789). You may want to try with a higher value of support_fraction (current value: 0.545).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-20.641700835827514 > -51.876250694561222). You may want to try with a higher value of support_fraction (current value: 0.545).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-20.180319402843946 > -50.763530128949789). You may want to try with a higher value of support_fraction (current value: 0.545).
/opt/venv/lib/python3.12/site-packages/sklearn/covariance/_robust_covariance.py:188: RuntimeWarning: Determinant has increased; this should not happen: log(det) > log(previous_det) (-20.641700835827514 > -51.876250694561222). You may want to try with a higher value of support_fraction (current value: 0.545).
2026-06-03 05:09:56,651 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Effective sample size for chrX and chrY obtained
2026-06-03 05:09:56,652 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Get the final double norm values, adjusting for ploidies
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:239: RuntimeWarning: divide by zero encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:239: RuntimeWarning: invalid value encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: divide by zero encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: invalid value encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: divide by zero encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: invalid value encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: divide by zero encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: invalid value encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: divide by zero encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: invalid value encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: divide by zero encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: invalid value encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: divide by zero encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: invalid value encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: divide by zero encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: invalid value encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: divide by zero encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: invalid value encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: divide by zero encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: invalid value encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: divide by zero encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: invalid value encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: divide by zero encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: invalid value encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: divide by zero encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: invalid value encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: divide by zero encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: invalid value encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: divide by zero encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: invalid value encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: divide by zero encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: invalid value encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: divide by zero encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: invalid value encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: divide by zero encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: invalid value encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: divide by zero encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: invalid value encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: divide by zero encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: invalid value encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: divide by zero encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: invalid value encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: divide by zero encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: invalid value encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: divide by zero encountered in divide
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:249: RuntimeWarning: invalid value encountered in divide
2026-06-03 05:09:57,849 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Double norm values obtained
2026-06-03 05:09:57,849 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Format and write the data for sample-probe combinations
2026-06-03 05:10:20,551 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Sample-probe data written
2026-06-03 05:10:20,551 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Sample-level metrics. Calculating, formatting, and saving
/opt/venv/lib/python3.12/site-packages/numpy/lib/_nanfunctions_impl.py:1213: RuntimeWarning: Mean of empty slice
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:316: SmallSampleWarning: One or more sample arguments is too small; all returned values will be NaN. See documentation for sample size requirements.
/opt/venv/lib/python3.12/site-packages/numpy/lib/_nanfunctions_impl.py:1997: RuntimeWarning: Degrees of freedom <= 0 for slice.
/opt/venv/lib/python3.12/site-packages/cnv_pipe/batch/preprocess.py:318: SmallSampleWarning: One or more sample arguments is too small; all returned values will be NaN. See documentation for sample size requirements.
2026-06-03 05:10:23,411 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Sample-level metrics written
2026-06-03 05:10:23,411 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Save ploidy estimates
2026-06-03 05:10:23,419 - cnv_pipe.cnv_pipe.batch.preprocess - INFO - Batch pre-processing complete