Downloading: s3://natera-platform-sandbox/pipeline-resources/ngi-igenomes/igenomes/Homo_sapiens/GATK/GRCh38/Sequence/WholeGenomeFasta/Homo_sapiens_assembly38.fasta
  Downloading: s3://natera-rnd-pltf-dev-nextflow-scratch-01/work/ee/435cecb8b028c4a30617b81e6877ff/Sig_18_Blood_probe_sample.parquet
  Downloading: s3://natera-rnd-pltf-dev-nextflow-scratch-01/work/01/c4430a107f8548b36c112e1843da99/.command.sh
  Downloading: s3://natera-rnd-pltf-dev-nextflow-scratch-01/work/01/c4430a107f8548b36c112e1843da99/.command.run
==> STAGING COMPLETE (4 inputs)

mkdir -p failed for path /.config/matplotlib: [Errno 13] Permission denied: '/.config'
Matplotlib created a temporary cache directory at /tmp/matplotlib-o7nzb84b because there was an issue with the default path (/.config/matplotlib); it is highly recommended to set the MPLCONFIGDIR environment variable to a writable directory, in particular to speed up the import of Matplotlib and to better support multiprocessing.
2026-06-08 22:43:52,674 - cnv_pipe.cnv_pipe.batch.probe_merger - INFO - Reading input file: Sig_18_Blood_probe_sample.parquet
2026-06-08 22:43:52,726 - cnv_pipe.cnv_pipe.batch.probe_merger - INFO - Reading reference genome FASTA file: Homo_sapiens_assembly38.fasta
2026-06-08 22:44:02,860 - cnv_pipe.cnv_pipe.batch.probe_merger - INFO - Filtered out 458515 probes with mask flags (mask_probes_low, mask_probes_blacklist)
2026-06-08 22:44:02,861 - cnv_pipe.cnv_pipe.batch.probe_merger - INFO - Failed probes (mask_probes_low or mask_probe_model_failed): 458430
2026-06-08 22:44:02,861 - cnv_pipe.cnv_pipe.batch.probe_merger - INFO - Remaining probes: 4479
2026-06-08 22:44:02,861 - cnv_pipe.cnv_pipe.batch.probe_merger - INFO - Single sample — skipping batch FC statistics
2026-06-08 22:44:02,861 - cnv_pipe.cnv_pipe.batch.probe_merger - INFO - Processing 1 samples with 1 threads
2026-06-08 22:45:39,032 - cnv_pipe.cnv_pipe.batch.probe_merger - INFO - Processed Sig_18_Blood: 8 deletions, 1 duplications
2026-06-08 22:45:39,032 - cnv_pipe.cnv_pipe.batch.probe_merger - INFO - 
Processing complete!
2026-06-08 22:45:39,032 - cnv_pipe.cnv_pipe.batch.probe_merger - INFO - Total samples successfully processed: 1
2026-06-08 22:45:39,032 - cnv_pipe.cnv_pipe.batch.probe_merger - INFO - Number of samples failed QC: 0
2026-06-08 22:45:39,032 - cnv_pipe.cnv_pipe.batch.probe_merger - INFO - Number of probes failed QC: 458430
2026-06-08 22:45:39,032 - cnv_pipe.cnv_pipe.batch.probe_merger - INFO - Total deletions: 8
2026-06-08 22:45:39,032 - cnv_pipe.cnv_pipe.batch.probe_merger - INFO - Total duplications: 1