File Info

Filename
variant_qc.json
Full Path
s3://natera-rnd-pltf-dev-nextflow-data-01/users/mipeters/semiproductionize/sarek/69814f07/std_run_largest2_smallest2_8a99ba01/reports/variant_qc.json
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7.3 KB
Published
Feb 02, 2026 10:45 PM
{
  "metadata": {
    "version": "1.0",
    "mode": "variant",
    "tools": [
      "contamination",
      "ngscheckmate",
      "bcftools",
      "snpeff"
    ]
  },
  "pairs": {
    "1029_BICA-T1-TDNA-1_23FC2GLT4_s33_vs_1029_BICA-N1-BDNA-1_2375WFLT3_s32": {
      "tumor_sample": "1029_BICA-T1-TDNA-1_23FC2GLT4_s33",
      "normal_sample": "1029_BICA-N1-BDNA-1_2375WFLT3_s32",
      "contamination": {
        "normal_contamination_pct": 0.044,
        "tumor_contamination_pct": 0.556
      },
      "sample_identity": {
        "tumor_normal_correlation": 0.9824,
        "matched": true
      },
      "callers": {
        "mutect2": {
          "num_snps": 16897,
          "num_indels": 3732,
          "num_mnps": 1358,
          "ts_tv_ratio": 2.44,
          "substitutions": {
            "A>C": 368,
            "A>G": 909,
            "A>T": 474,
            "C>A": 1239,
            "C>G": 424,
            "C>T": 5298,
            "G>A": 4978,
            "G>C": 403,
            "G>T": 1181,
            "T>A": 521,
            "T>C": 896,
            "T>G": 332
          },
          "snpeff": {
            "missense_silent_ratio": 1.627313,
            "impact_high": 0,
            "impact_moderate": 0,
            "impact_low": 0,
            "impact_modifier": 0
          }
        },
        "tnseq": {
          "num_snps": 38777,
          "num_indels": 4950,
          "num_mnps": 1853,
          "ts_tv_ratio": 2.66,
          "substitutions": {
            "A>C": 1001,
            "A>G": 4622,
            "A>T": 916,
            "C>A": 2000,
            "C>G": 1445,
            "C>T": 9605,
            "G>A": 9447,
            "G>C": 1414,
            "G>T": 1914,
            "T>A": 966,
            "T>C": 4629,
            "T>G": 984
          },
          "snpeff": {
            "missense_silent_ratio": 1.149176,
            "impact_high": 0,
            "impact_moderate": 0,
            "impact_low": 0,
            "impact_modifier": 0
          }
        }
      }
    },
    "1029_BBS1-T1-TDNA-1_23FC2GLT4_s23_vs_1029_BBS1-N1-BDNA-1_2375WFLT3_s23": {
      "tumor_sample": "1029_BBS1-T1-TDNA-1_23FC2GLT4_s23",
      "normal_sample": "1029_BBS1-N1-BDNA-1_2375WFLT3_s23",
      "contamination": {
        "normal_contamination_pct": 0.046,
        "tumor_contamination_pct": 0.194
      },
      "sample_identity": {
        "tumor_normal_correlation": 0.9749,
        "matched": true
      },
      "callers": {
        "mutect2": {
          "num_snps": 4919,
          "num_indels": 3949,
          "num_mnps": 656,
          "ts_tv_ratio": 1.48,
          "substitutions": {
            "A>C": 235,
            "A>G": 644,
            "A>T": 217,
            "C>A": 287,
            "C>G": 255,
            "C>T": 869,
            "G>A": 850,
            "G>C": 291,
            "G>T": 298,
            "T>A": 207,
            "T>C": 637,
            "T>G": 232
          },
          "snpeff": {
            "missense_silent_ratio": 1.488605,
            "impact_high": 0,
            "impact_moderate": 0,
            "impact_low": 0,
            "impact_modifier": 0
          }
        },
        "tnseq": {
          "num_snps": 26587,
          "num_indels": 5017,
          "num_mnps": 1053,
          "ts_tv_ratio": 2.56,
          "substitutions": {
            "A>C": 858,
            "A>G": 4200,
            "A>T": 647,
            "C>A": 1005,
            "C>G": 1207,
            "C>T": 5255,
            "G>A": 5380,
            "G>C": 1260,
            "G>T": 997,
            "T>A": 645,
            "T>C": 4384,
            "T>G": 878
          },
          "snpeff": {
            "missense_silent_ratio": 0.963174,
            "impact_high": 0,
            "impact_moderate": 0,
            "impact_low": 0,
            "impact_modifier": 0
          }
        }
      }
    },
    "1029_BG5-T1-TDNA-1_23FC2GLT4_s29_vs_1029_BG5-N1-BDNA-1_2375WFLT3_s29": {
      "tumor_sample": "1029_BG5-T1-TDNA-1_23FC2GLT4_s29",
      "normal_sample": "1029_BG5-N1-BDNA-1_2375WFLT3_s29",
      "contamination": {
        "normal_contamination_pct": 0.082,
        "tumor_contamination_pct": 0.646
      },
      "sample_identity": {
        "tumor_normal_correlation": 0.9521,
        "matched": true
      },
      "callers": {
        "mutect2": {
          "num_snps": 802,
          "num_indels": 216,
          "num_mnps": 47,
          "ts_tv_ratio": 1.93,
          "substitutions": {
            "A>C": 20,
            "A>G": 91,
            "A>T": 30,
            "C>A": 68,
            "C>G": 24,
            "C>T": 176,
            "G>A": 168,
            "G>C": 24,
            "G>T": 66,
            "T>A": 27,
            "T>C": 94,
            "T>G": 15
          },
          "snpeff": {
            "missense_silent_ratio": 2.130435,
            "impact_high": 0,
            "impact_moderate": 0,
            "impact_low": 0,
            "impact_modifier": 0
          }
        },
        "tnseq": {
          "num_snps": 20675,
          "num_indels": 784,
          "num_mnps": 406,
          "ts_tv_ratio": 2.94,
          "substitutions": {
            "A>C": 604,
            "A>G": 3524,
            "A>T": 371,
            "C>A": 749,
            "C>G": 930,
            "C>T": 4106,
            "G>A": 4274,
            "G>C": 913,
            "G>T": 711,
            "T>A": 377,
            "T>C": 3544,
            "T>G": 593
          },
          "snpeff": {
            "missense_silent_ratio": 0.90002,
            "impact_high": 0,
            "impact_moderate": 0,
            "impact_low": 0,
            "impact_modifier": 0
          }
        }
      }
    },
    "1029_BBCQ-T1-TDNA-1_23FC2GLT4_s21_vs_1029_BBCQ-N1-BDNA-1_2375WFLT3_s21": {
      "tumor_sample": "1029_BBCQ-T1-TDNA-1_23FC2GLT4_s21",
      "normal_sample": "1029_BBCQ-N1-BDNA-1_2375WFLT3_s21",
      "contamination": {
        "normal_contamination_pct": 0.045,
        "tumor_contamination_pct": 0.518
      },
      "sample_identity": {
        "tumor_normal_correlation": 0.9521,
        "matched": true
      },
      "callers": {
        "mutect2": {
          "num_snps": 3702,
          "num_indels": 580,
          "num_mnps": 96,
          "ts_tv_ratio": 4.99,
          "substitutions": {
            "A>C": 43,
            "A>G": 133,
            "A>T": 72,
            "C>A": 146,
            "C>G": 53,
            "C>T": 1389,
            "G>A": 1426,
            "G>C": 57,
            "G>T": 151,
            "T>A": 66,
            "T>C": 138,
            "T>G": 30
          },
          "snpeff": {
            "missense_silent_ratio": 1.613291,
            "impact_high": 0,
            "impact_moderate": 0,
            "impact_low": 0,
            "impact_modifier": 0
          }
        },
        "tnseq": {
          "num_snps": 23603,
          "num_indels": 1227,
          "num_mnps": 443,
          "ts_tv_ratio": 3.22,
          "substitutions": {
            "A>C": 612,
            "A>G": 3562,
            "A>T": 457,
            "C>A": 778,
            "C>G": 913,
            "C>T": 5373,
            "G>A": 5510,
            "G>C": 1000,
            "G>T": 785,
            "T>A": 438,
            "T>C": 3572,
            "T>G": 620
          },
          "snpeff": {
            "missense_silent_ratio": 0.961299,
            "impact_high": 0,
            "impact_moderate": 0,
            "impact_low": 0,
            "impact_modifier": 0
          }
        }
      }
    }
  }
}