Matplotlib created a temporary config/cache directory at /tmp/matplotlib-kr99bkgs because the default path (/.config/matplotlib) is not a writable directory; it is highly recommended to set the MPLCONFIGDIR environment variable to a writable directory, in particular to speed up the import of Matplotlib and to better support multiprocessing. Fontconfig error: No writable cache directories Calling copy number with thresholds: -1.1 => 0, -0.25 => 1, 0.2 => 2, 0.7 => 3 Wrote Sig_18_tissue.recalibrated.somatic.call.cns with 6 regions Matplotlib created a temporary config/cache directory at /tmp/matplotlib-6di33v79 because the default path (/.config/matplotlib) is not a writable directory; it is highly recommended to set the MPLCONFIGDIR environment variable to a writable directory, in particular to speed up the import of Matplotlib and to better support multiprocessing. Fontconfig error: No writable cache directories