Downloading: s3://natera-rnd-pltf-dev-nextflow-scratch-01/work/83/a45f7bd4e8385d2aeedbf62f01177a/Sig_18_tissue.recalibrated.cns
  Downloading: s3://natera-rnd-pltf-dev-nextflow-scratch-01/work/0c/9f31c1fa91229a2f0b1c8af38b7a85/.command.run
  Downloading: s3://natera-rnd-pltf-dev-nextflow-scratch-01/work/0c/9f31c1fa91229a2f0b1c8af38b7a85/.command.sh
==> STAGING COMPLETE (3 inputs)

Matplotlib created a temporary config/cache directory at /tmp/matplotlib-kr99bkgs because the default path (/.config/matplotlib) is not a writable directory; it is highly recommended to set the MPLCONFIGDIR environment variable to a writable directory, in particular to speed up the import of Matplotlib and to better support multiprocessing.
Fontconfig error: No writable cache directories
Calling copy number with thresholds: -1.1 => 0, -0.25 => 1, 0.2 => 2, 0.7 => 3
Wrote Sig_18_tissue.recalibrated.somatic.call.cns with 6 regions
Matplotlib created a temporary config/cache directory at /tmp/matplotlib-6di33v79 because the default path (/.config/matplotlib) is not a writable directory; it is highly recommended to set the MPLCONFIGDIR environment variable to a writable directory, in particular to speed up the import of Matplotlib and to better support multiprocessing.
Fontconfig error: No writable cache directories