File Info

Filename
.command.log
Full Path
s3://natera-rnd-fsdx-dev-nextflow-scratch-01/work/3d/2d0aed8b32a32f069823bdaf9bf383/.command.log
Size
32.4 KB
Attempt
  Downloading: s3://fsdx-algo-644019535899-us-west-2-an/references/hg38.fa
  Downloading: s3://natera-rnd-fsdx-dev-nextflow-scratch-01/work/3d/2d0aed8b32a32f069823bdaf9bf383/.command.sh
  Downloading: s3://fsdx-algo-644019535899-us-west-2-an/references/hg38.fa.fai
  Downloading: s3://fsdx-algo-644019535899-us-west-2-an/TSO500/TST500C_manifest.bed
  Downloading: s3://fsdx-algo-644019535899-us-west-2-an/references/af-only-gnomad.hg38.vcf.gz
  Downloading: s3://fsdx-algo-644019535899-us-west-2-an/references/af-only-gnomad.hg38.vcf.gz.tbi
  Downloading: s3://lcgp-v1/analysis/20260410_LH01147_0003_A23LTV7LT4-30e8cff3-bb76-4fb1-8024-010a94113bb0/Logs_Intermediates/DragenCaller/LS0921/LS0921_tumor.bam
  Downloading: s3://fsdx-algo-644019535899-us-west-2-an/references/hg38.dict
  Downloading: s3://natera-rnd-fsdx-dev-nextflow-scratch-01/work/3d/2d0aed8b32a32f069823bdaf9bf383/.command.run
  Downloading: s3://lcgp-v1/analysis/20260410_LH01147_0003_A23LTV7LT4-30e8cff3-bb76-4fb1-8024-010a94113bb0/Logs_Intermediates/DragenCaller/LS0921/LS0921_tumor.bam.bai
==> STAGING COMPLETE (10 inputs)

22:44:11.056 INFO  NativeLibraryLoader - Loading libgkl_compression.so from jar:file:/gatk/gatk-package-4.5.0.0-local.jar!/com/intel/gkl/native/libgkl_compression.so
22:44:11.158 INFO  Mutect2 - ------------------------------------------------------------
22:44:11.160 INFO  Mutect2 - The Genome Analysis Toolkit (GATK) v4.5.0.0
22:44:11.160 INFO  Mutect2 - For support and documentation go to https://software.broadinstitute.org/gatk/
22:44:11.160 INFO  Mutect2 - Executing as ?@nf-3d2d0aed8b32a32f069823bdaf9bf383-988fd-w28vz on Linux v6.12.88 amd64
22:44:11.160 INFO  Mutect2 - Java runtime: OpenJDK 64-Bit Server VM v17.0.9+9-Ubuntu-122.04
22:44:11.160 INFO  Mutect2 - Start Date/Time: June 8, 2026 at 10:44:11 PM GMT
22:44:11.160 INFO  Mutect2 - ------------------------------------------------------------
22:44:11.160 INFO  Mutect2 - ------------------------------------------------------------
22:44:11.161 INFO  Mutect2 - HTSJDK Version: 4.1.0
22:44:11.161 INFO  Mutect2 - Picard Version: 3.1.1
22:44:11.161 INFO  Mutect2 - Built for Spark Version: 3.5.0
22:44:11.162 INFO  Mutect2 - HTSJDK Defaults.COMPRESSION_LEVEL : 2
22:44:11.162 INFO  Mutect2 - HTSJDK Defaults.USE_ASYNC_IO_READ_FOR_SAMTOOLS : false
22:44:11.162 INFO  Mutect2 - HTSJDK Defaults.USE_ASYNC_IO_WRITE_FOR_SAMTOOLS : true
22:44:11.162 INFO  Mutect2 - HTSJDK Defaults.USE_ASYNC_IO_WRITE_FOR_TRIBBLE : false
22:44:11.162 INFO  Mutect2 - Deflater: IntelDeflater
22:44:11.162 INFO  Mutect2 - Inflater: IntelInflater
22:44:11.162 INFO  Mutect2 - GCS max retries/reopens: 20
22:44:11.162 INFO  Mutect2 - Requester pays: disabled
22:44:11.163 INFO  Mutect2 - Initializing engine
WARNING: BAM index file /tmp/nxf.KmgEqbjZlB/LS0921_tumor.bam.bai is older than BAM /tmp/nxf.KmgEqbjZlB/LS0921_tumor.bam
22:44:11.344 INFO  FeatureManager - Using codec VCFCodec to read file file:///tmp/nxf.KmgEqbjZlB/af-only-gnomad.hg38.vcf.gz
22:44:11.466 INFO  FeatureManager - Using codec BEDCodec to read file file:///tmp/nxf.KmgEqbjZlB/TST500C_manifest.bed
22:44:11.503 INFO  IntervalArgumentCollection - Processing 1970331 bp from intervals
22:44:11.534 INFO  Mutect2 - Done initializing engine
22:44:11.548 INFO  NativeLibraryLoader - Loading libgkl_utils.so from jar:file:/gatk/gatk-package-4.5.0.0-local.jar!/com/intel/gkl/native/libgkl_utils.so
22:44:11.550 INFO  NativeLibraryLoader - Loading libgkl_smithwaterman.so from jar:file:/gatk/gatk-package-4.5.0.0-local.jar!/com/intel/gkl/native/libgkl_smithwaterman.so
22:44:11.551 INFO  IntelSmithWaterman - Using CPU-supported AVX-512 instructions
22:44:11.551 INFO  SmithWatermanAligner - Using AVX accelerated SmithWaterman implementation
22:44:11.563 INFO  NativeLibraryLoader - Loading libgkl_pairhmm_omp.so from jar:file:/gatk/gatk-package-4.5.0.0-local.jar!/com/intel/gkl/native/libgkl_pairhmm_omp.so
22:44:11.572 INFO  IntelPairHmm - Using CPU-supported AVX-512 instructions
22:44:11.572 INFO  IntelPairHmm - Flush-to-zero (FTZ) is enabled when running PairHMM
22:44:11.572 INFO  IntelPairHmm - Available threads: 384
22:44:11.572 INFO  IntelPairHmm - Requested threads: 4
22:44:11.572 INFO  PairHMM - Using the OpenMP multi-threaded AVX-accelerated native PairHMM implementation
22:44:11.617 INFO  ProgressMeter - Starting traversal
22:44:11.617 INFO  ProgressMeter -        Current Locus  Elapsed Minutes     Regions Processed   Regions/Minute
22:44:21.802 INFO  ProgressMeter -        chr1:11146674              0.2                   100            589.2
22:44:32.251 INFO  ProgressMeter -        chr1:15930465              0.3                   190            552.5
22:44:43.105 INFO  ProgressMeter -        chr1:18744812              0.5                   290            552.6
22:44:53.276 INFO  ProgressMeter -        chr1:26779064              0.7                   380            547.3
22:45:03.432 INFO  ProgressMeter -        chr1:43340106              0.9                   510            590.6
22:45:14.039 INFO  ProgressMeter -        chr1:64873368              1.0                   650            624.8
22:45:24.453 INFO  ProgressMeter -       chr1:119514331              1.2                   780            642.5
22:45:34.543 INFO  ProgressMeter -       chr1:156872764              1.4                   890            644.0
22:45:45.011 INFO  ProgressMeter -       chr1:158666314              1.6                   990            636.0
22:45:55.528 INFO  ProgressMeter -       chr1:204424850              1.7                  1140            658.3
22:46:05.964 INFO  ProgressMeter -       chr1:226065654              1.9                  1280            671.6
22:46:18.124 INFO  ProgressMeter -       chr1:243504447              2.1                  1380            654.5
22:46:28.816 INFO  ProgressMeter -       chr10:32010515              2.3                  1500            656.0
22:46:39.083 INFO  ProgressMeter -       chr10:43115785              2.5                  1600            651.0
22:46:50.315 INFO  ProgressMeter -       chr10:68573777              2.6                  1690            639.0
22:47:02.894 INFO  ProgressMeter -      chr10:101770444              2.9                  1830            641.1
22:47:13.305 INFO  ProgressMeter -      chr10:110602453              3.0                  1950            644.0
22:47:23.362 INFO  ProgressMeter -      chr10:121515115              3.2                  2040            638.4
22:47:33.650 INFO  ProgressMeter -       chr11:64369444              3.4                  2170            644.5
22:47:44.319 INFO  ProgressMeter -       chr11:69701530              3.5                  2300            648.8
22:47:56.320 INFO  ProgressMeter -       chr11:69810603              3.7                  2390            638.2
22:48:06.681 INFO  ProgressMeter -       chr11:77349174              3.9                  2480            633.0
22:48:17.459 INFO  ProgressMeter -      chr11:102229809              4.1                  2620            639.4
22:48:27.634 INFO  ProgressMeter -      chr11:108325308              4.3                  2710            635.1
22:48:38.869 INFO  ProgressMeter -      chr11:118505400              4.5                  2830            635.4
22:48:49.176 INFO  ProgressMeter -      chr11:125667036              4.6                  2940            635.5
22:49:00.371 INFO  ProgressMeter -      chr11:128811980              4.8                  3030            629.6
22:49:10.708 INFO  ProgressMeter -        chr12:4375255              5.0                  3160            633.9
22:49:20.899 INFO  ProgressMeter -        chr12:6593089              5.2                  3280            636.3
22:49:31.541 INFO  ProgressMeter -       chr12:11859785              5.3                  3360            630.2
22:49:43.217 INFO  ProgressMeter -       chr12:11868686              5.5                  3440            622.4
22:49:53.743 INFO  ProgressMeter -       chr12:31797567              5.7                  3570            626.1
22:50:04.072 INFO  ProgressMeter -       chr12:49032739              5.9                  3670            624.8
22:50:14.625 INFO  ProgressMeter -       chr12:49054305              6.1                  3770            623.1
22:50:25.552 INFO  ProgressMeter -       chr12:57094487              6.2                  3910            627.4
22:50:36.129 INFO  ProgressMeter -       chr12:68838163              6.4                  4040            630.4
22:50:46.941 INFO  ProgressMeter -      chr12:132634287              6.6                  4180            634.4
22:50:57.569 INFO  ProgressMeter -       chr13:21681874              6.8                  4300            635.5
22:51:08.048 INFO  ProgressMeter -       chr13:28368596              6.9                  4430            638.3
22:51:18.562 INFO  ProgressMeter -       chr13:32332681              7.1                  4500            632.4
22:51:28.827 INFO  ProgressMeter -       chr13:32398160              7.3                  4590            629.9
22:51:38.946 INFO  ProgressMeter -      chr13:102856050              7.5                  4740            635.8
22:51:50.345 INFO  ProgressMeter -       chr14:25381560              7.6                  4860            635.7
22:52:00.642 INFO  ProgressMeter -       chr14:67835078              7.8                  4980            637.1
22:52:11.426 INFO  ProgressMeter -      chr14:102101922              8.0                  5100            637.8
22:52:22.264 INFO  ProgressMeter -       chr15:34356594              8.2                  5180            633.5
22:52:33.888 INFO  ProgressMeter -       chr15:41766677              8.4                  5280            630.7
22:52:44.796 INFO  ProgressMeter -       chr15:87978466              8.6                  5410            632.5
22:52:55.234 INFO  ProgressMeter -       chr15:90784919              8.7                  5550            636.0
22:53:05.984 INFO  ProgressMeter -         chr16:293486              8.9                  5680            637.8
22:53:16.557 INFO  ProgressMeter -        chr16:3595603              9.1                  5840            643.0
22:53:26.983 INFO  ProgressMeter -        chr16:9849754              9.3                  5950            642.8
22:53:37.171 INFO  ProgressMeter -       chr16:50754317              9.4                  6060            642.9
22:53:48.926 INFO  ProgressMeter -       chr16:72793897              9.6                  6190            643.3
22:53:59.559 INFO  ProgressMeter -       chr16:81858261              9.8                  6270            639.9
22:54:09.934 INFO  ProgressMeter -       chr16:89291066             10.0                  6380            639.8
22:54:20.214 INFO  ProgressMeter -        chr17:7675051             10.1                  6500            640.8
22:54:31.022 INFO  ProgressMeter -       chr17:16108784             10.3                  6640            643.2
22:54:41.215 INFO  ProgressMeter -       chr17:31947615             10.5                  6790            647.1
22:54:51.960 INFO  ProgressMeter -       chr17:39727687             10.7                  6930            649.3
22:55:02.124 INFO  ProgressMeter -       chr17:43045688             10.8                  7100            654.9
22:55:12.313 INFO  ProgressMeter -       chr17:43115724             11.0                  7190            652.9
22:55:22.961 INFO  ProgressMeter -       chr17:43539558             11.2                  7270            649.7
22:55:33.645 INFO  ProgressMeter -       chr17:45273737             11.4                  7340            645.7
22:55:44.529 INFO  ProgressMeter -       chr17:60600413             11.5                  7480            647.7
22:55:54.903 INFO  ProgressMeter -       chr17:68551082             11.7                  7600            648.4
22:56:05.170 INFO  ProgressMeter -       chr18:42081121             11.9                  7750            651.7
22:56:15.312 INFO  ProgressMeter -       chr18:59901332             12.1                  7860            651.7
22:56:25.959 INFO  ProgressMeter -        chr19:5211639             12.2                  8030            656.1
22:56:36.210 INFO  ProgressMeter -       chr19:10156389             12.4                  8160            657.5
22:56:46.543 INFO  ProgressMeter -       chr19:15170669             12.6                  8300            659.7
22:56:56.980 INFO  ProgressMeter -       chr19:17843378             12.8                  8420            660.1
22:57:07.258 INFO  ProgressMeter -       chr19:35721723             12.9                  8550            661.4
22:57:18.199 INFO  ProgressMeter -       chr19:41260113             13.1                  8690            662.9
22:57:28.311 INFO  ProgressMeter -       chr19:45362673             13.3                  8780            661.2
22:57:38.694 INFO  ProgressMeter -         chr2:9945620             13.5                  8930            663.9
22:57:48.741 INFO  ProgressMeter -        chr2:25252243             13.6                  9030            663.1
22:57:59.978 INFO  ProgressMeter -        chr2:29224093             13.8                  9130            661.3
22:58:10.789 INFO  ProgressMeter -        chr2:39346086             14.0                  9200            657.8
22:58:21.119 INFO  ProgressMeter -        chr2:47478270             14.2                  9300            656.9
22:58:31.422 INFO  ProgressMeter -        chr2:96265136             14.3                  9420            657.4
22:58:41.744 INFO  ProgressMeter -       chr2:111125440             14.5                  9540            657.8
22:58:52.835 INFO  ProgressMeter -       chr2:113224271             14.7                  9620            655.0
22:59:03.616 INFO  ProgressMeter -       chr2:113231490             14.9                  9680            651.1
22:59:13.774 INFO  ProgressMeter -       chr2:127292806             15.0                  9760            649.1
22:59:23.808 INFO  ProgressMeter -       chr2:140982158             15.2                  9900            651.2
22:59:34.270 INFO  ProgressMeter -       chr2:197396054             15.4                 10040            652.9
22:59:44.816 INFO  ProgressMeter -       chr2:214767580             15.6                 10180            654.5
22:59:54.827 INFO  ProgressMeter -       chr2:222206057             15.7                 10250            652.0
23:00:05.184 INFO  ProgressMeter -       chr2:222215716             15.9                 10320            649.4
23:00:15.709 INFO  ProgressMeter -       chr2:224569687             16.1                 10410            647.9
23:00:26.820 INFO  ProgressMeter -       chr20:32435877             16.3                 10520            647.3
23:00:36.930 INFO  ProgressMeter -       chr20:43189687             16.4                 10660            649.1
23:00:47.708 INFO  ProgressMeter -       chr20:58854330             16.6                 10760            648.1
23:00:57.784 INFO  ProgressMeter -       chr21:38471027             16.8                 10870            648.2
23:01:08.344 INFO  ProgressMeter -       chr21:41491059             16.9                 10950            646.2
23:01:19.727 INFO  ProgressMeter -       chr21:41502289             17.1                 11010            642.5
23:01:30.093 INFO  ProgressMeter -       chr22:20996884             17.3                 11120            642.5
23:01:40.484 INFO  ProgressMeter -       chr22:28700068             17.5                 11220            641.8
23:01:51.818 INFO  ProgressMeter -       chr22:29291560             17.7                 11320            640.6
23:02:01.834 INFO  ProgressMeter -          chr3:920014             17.8                 11440            641.4
23:02:13.100 INFO  ProgressMeter -        chr3:12356151             18.0                 11550            640.8
23:02:24.560 INFO  ProgressMeter -        chr3:12363838             18.2                 11610            637.4
23:02:35.003 INFO  ProgressMeter -        chr3:12373301             18.4                 11670            634.6
23:02:45.388 INFO  ProgressMeter -        chr3:12585930             18.6                 11740            632.4
23:02:55.826 INFO  ProgressMeter -        chr3:38140755             18.7                 11840            631.9
23:03:06.320 INFO  ProgressMeter -        chr3:49362494             18.9                 11940            631.4
23:03:16.456 INFO  ProgressMeter -        chr3:52576539             19.1                 12060            632.1
23:03:27.116 INFO  ProgressMeter -        chr3:89395961             19.3                 12190            633.0
23:03:37.273 INFO  ProgressMeter -       chr3:136502607             19.4                 12310            633.6
23:03:47.388 INFO  ProgressMeter -       chr3:142550130             19.6                 12440            634.8
23:03:57.441 INFO  ProgressMeter -       chr3:181712710             19.8                 12570            636.0
23:04:07.754 INFO  ProgressMeter -       chr3:186786521             19.9                 12680            636.0
23:04:18.063 INFO  ProgressMeter -         chr4:1799745             20.1                 12820            637.6
23:04:28.816 INFO  ProgressMeter -        chr4:54262543             20.3                 12960            638.8
23:04:39.025 INFO  ProgressMeter -        chr4:55092615             20.5                 13070            638.9
23:04:49.061 INFO  ProgressMeter -        chr4:83462839             20.6                 13190            639.5
23:04:59.107 INFO  ProgressMeter -       chr4:105242303             20.8                 13280            638.7
23:05:09.185 INFO  ProgressMeter -       chr4:168742391             21.0                 13410            639.8
23:05:19.248 INFO  ProgressMeter -       chr4:186663297             21.1                 13510            639.5
23:05:29.453 INFO  ProgressMeter -        chr5:38954772             21.3                 13610            639.0
23:05:39.824 INFO  ProgressMeter -        chr5:56884662             21.5                 13750            640.4
23:05:50.272 INFO  ProgressMeter -       chr5:112838258             21.6                 13910            642.7
23:06:01.011 INFO  ProgressMeter -       chr5:132609281             21.8                 14010            642.0
23:06:11.437 INFO  ProgressMeter -       chr5:150059698             22.0                 14130            642.4
23:06:22.038 INFO  ProgressMeter -       chr5:171391303             22.2                 14250            642.7
23:06:32.461 INFO  ProgressMeter -       chr5:177209948             22.3                 14340            641.7
23:06:42.660 INFO  ProgressMeter -          chr6:401422             22.5                 14470            642.6
23:06:52.712 INFO  ProgressMeter -        chr6:26250277             22.7                 14610            644.0
23:07:02.774 INFO  ProgressMeter -        chr6:30714025             22.9                 14690            642.8
23:07:12.832 INFO  ProgressMeter -        chr6:41940950             23.0                 14820            643.8
23:07:23.059 INFO  ProgressMeter -       chr6:111700138             23.2                 14960            645.1
23:07:34.046 INFO  ProgressMeter -       chr6:117321887             23.4                 15030            643.0
23:07:45.188 INFO  ProgressMeter -       chr6:117330563             23.6                 15110            641.4
23:07:58.356 INFO  ProgressMeter -       chr6:117338829             23.8                 15180            638.4
23:08:08.470 INFO  ProgressMeter -       chr6:135204827             23.9                 15280            638.1
23:08:19.288 INFO  ProgressMeter -       chr6:135212627             24.1                 15340            635.8
23:08:29.482 INFO  ProgressMeter -       chr6:137881033             24.3                 15420            634.6
23:08:40.403 INFO  ProgressMeter -       chr6:156778692             24.5                 15530            634.4
23:08:50.603 INFO  ProgressMeter -       chr6:163534980             24.6                 15660            635.3
23:09:01.147 INFO  ProgressMeter -        chr7:13906758             24.8                 15770            635.2
23:09:12.053 INFO  ProgressMeter -        chr7:13937087             25.0                 15830            633.0
23:09:23.164 INFO  ProgressMeter -        chr7:13945407             25.2                 15900            631.1
23:09:33.589 INFO  ProgressMeter -        chr7:13952288             25.4                 15950            628.8
23:09:45.208 INFO  ProgressMeter -        chr7:13960491             25.6                 16020            626.8
23:09:59.197 INFO  ProgressMeter -        chr7:13971662             25.8                 16100            624.2
23:10:09.499 INFO  ProgressMeter -        chr7:13977531             26.0                 16140            621.6
23:10:22.983 INFO  ProgressMeter -        chr7:13989693             26.2                 16220            619.3
23:10:34.405 INFO  ProgressMeter -        chr7:55167181             26.4                 16320            618.7
23:10:44.599 INFO  ProgressMeter -        chr7:55178373             26.5                 16380            617.0
23:10:54.814 INFO  ProgressMeter -        chr7:78343776             26.7                 16470            616.4
23:11:05.372 INFO  ProgressMeter -       chr7:102197279             26.9                 16610            617.6
23:11:15.748 INFO  ProgressMeter -       chr7:116771496             27.1                 16720            617.7
23:11:26.310 INFO  ProgressMeter -       chr7:140792453             27.2                 16830            617.7
23:11:36.926 INFO  ProgressMeter -       chr7:152148969             27.4                 16970            618.9
23:11:47.037 INFO  ProgressMeter -       chr7:152220678             27.6                 17060            618.3
23:11:57.415 INFO  ProgressMeter -        chr8:32548728             27.8                 17190            619.2
23:12:07.610 INFO  ProgressMeter -        chr8:37838954             27.9                 17290            619.0
23:12:17.983 INFO  ProgressMeter -        chr8:42048662             28.1                 17410            619.4
23:12:28.091 INFO  ProgressMeter -        chr8:47935826             28.3                 17530            620.0
23:12:38.820 INFO  ProgressMeter -        chr8:89971171             28.5                 17670            621.0
23:12:48.833 INFO  ProgressMeter -       chr8:127740939             28.6                 17770            620.9
23:12:59.076 INFO  ProgressMeter -         chr9:5534926             28.8                 17900            621.7
23:13:09.217 INFO  ProgressMeter -        chr9:35074106             29.0                 18020            622.2
23:13:20.790 INFO  ProgressMeter -        chr9:84742886             29.2                 18120            621.6
23:13:31.286 INFO  ProgressMeter -        chr9:84861038             29.3                 18170            619.5
23:13:42.014 INFO  ProgressMeter -        chr9:84873095             29.5                 18230            617.8
23:13:53.461 INFO  ProgressMeter -        chr9:85024803             29.7                 18310            616.6
23:14:03.704 INFO  ProgressMeter -        chr9:95469007             29.9                 18400            616.0
23:14:14.544 INFO  ProgressMeter -       chr9:130886079             30.0                 18530            616.7
23:14:25.238 INFO  ProgressMeter -       chr9:136511150             30.2                 18630            616.3
23:14:35.240 INFO  ProgressMeter -        chrX:40074668             30.4                 18760            617.2
23:14:45.499 INFO  ProgressMeter -        chrX:49030188             30.6                 18890            618.0
23:14:55.866 INFO  ProgressMeter -        chrX:53196908             30.7                 18970            617.2
23:15:07.061 INFO  ProgressMeter -        chrX:64192574             30.9                 19090            617.3
23:15:17.078 INFO  ProgressMeter -        chrX:71135090             31.1                 19210            617.9
23:15:27.126 INFO  ProgressMeter -        chrX:77652112             31.3                 19320            618.1
23:15:39.429 INFO  ProgressMeter -       chrX:124066173             31.5                 19460            618.5
23:15:46.899 INFO  Mutect2 - 426330 read(s) filtered by: MappingQualityReadFilter 
0 read(s) filtered by: MappingQualityAvailableReadFilter 
0 read(s) filtered by: MappingQualityNotZeroReadFilter 
0 read(s) filtered by: MappedReadFilter 
0 read(s) filtered by: NotSecondaryAlignmentReadFilter 
0 read(s) filtered by: NotDuplicateReadFilter 
0 read(s) filtered by: PassesVendorQualityCheckReadFilter 
0 read(s) filtered by: NonChimericOriginalAlignmentReadFilter 
0 read(s) filtered by: NonZeroReferenceLengthAlignmentReadFilter 
2 read(s) filtered by: ReadLengthReadFilter 
70 read(s) filtered by: GoodCigarReadFilter 
0 read(s) filtered by: WellformedReadFilter 
426402 total reads filtered out of 52297790 reads processed
23:15:46.900 INFO  ProgressMeter -        chrY:19773323             31.6                 19586            620.0
23:15:46.900 INFO  ProgressMeter - Traversal complete. Processed 19586 total regions in 31.6 minutes.
23:15:46.915 INFO  VectorLoglessPairHMM - Time spent in setup for JNI call : 4.092236924
23:15:46.916 INFO  PairHMM - Total compute time in PairHMM computeLogLikelihoods() : 155.224035433
23:15:46.916 INFO  SmithWatermanAligner - Total compute time in native Smith-Waterman : 6.07 sec
23:15:46.916 INFO  Mutect2 - Shutting down engine
[June 8, 2026 at 11:15:46 PM GMT] org.broadinstitute.hellbender.tools.walkers.mutect.Mutect2 done. Elapsed time: 31.60 minutes.
Runtime.totalMemory()=2239758336
Tool returned:
SUCCESS
Using GATK jar /gatk/gatk-package-4.5.0.0-local.jar
Running:
    java -Dsamjdk.use_async_io_read_samtools=false -Dsamjdk.use_async_io_write_samtools=true -Dsamjdk.use_async_io_write_tribble=false -Dsamjdk.compression_level=2 -Xmx14g -jar /gatk/gatk-package-4.5.0.0-local.jar Mutect2 -R hg38.fa -I LS0921_tumor.bam --tumor-sample LS0921 -L TST500C_manifest.bed -O LS0921.mutect2.raw.vcf.gz --native-pair-hmm-threads 4 --max-mnp-distance 0 --germline-resource af-only-gnomad.hg38.vcf.gz
23:15:48.249 INFO  NativeLibraryLoader - Loading libgkl_compression.so from jar:file:/gatk/gatk-package-4.5.0.0-local.jar!/com/intel/gkl/native/libgkl_compression.so
23:15:48.367 INFO  FilterMutectCalls - ------------------------------------------------------------
23:15:48.369 INFO  FilterMutectCalls - The Genome Analysis Toolkit (GATK) v4.5.0.0
23:15:48.369 INFO  FilterMutectCalls - For support and documentation go to https://software.broadinstitute.org/gatk/
23:15:48.369 INFO  FilterMutectCalls - Executing as ?@nf-3d2d0aed8b32a32f069823bdaf9bf383-988fd-w28vz on Linux v6.12.88 amd64
23:15:48.369 INFO  FilterMutectCalls - Java runtime: OpenJDK 64-Bit Server VM v17.0.9+9-Ubuntu-122.04
23:15:48.369 INFO  FilterMutectCalls - Start Date/Time: June 8, 2026 at 11:15:48 PM GMT
23:15:48.369 INFO  FilterMutectCalls - ------------------------------------------------------------
23:15:48.369 INFO  FilterMutectCalls - ------------------------------------------------------------
23:15:48.370 INFO  FilterMutectCalls - HTSJDK Version: 4.1.0
23:15:48.370 INFO  FilterMutectCalls - Picard Version: 3.1.1
23:15:48.370 INFO  FilterMutectCalls - Built for Spark Version: 3.5.0
23:15:48.370 INFO  FilterMutectCalls - HTSJDK Defaults.COMPRESSION_LEVEL : 2
23:15:48.370 INFO  FilterMutectCalls - HTSJDK Defaults.USE_ASYNC_IO_READ_FOR_SAMTOOLS : false
23:15:48.370 INFO  FilterMutectCalls - HTSJDK Defaults.USE_ASYNC_IO_WRITE_FOR_SAMTOOLS : true
23:15:48.370 INFO  FilterMutectCalls - HTSJDK Defaults.USE_ASYNC_IO_WRITE_FOR_TRIBBLE : false
23:15:48.370 INFO  FilterMutectCalls - Deflater: IntelDeflater
23:15:48.371 INFO  FilterMutectCalls - Inflater: IntelInflater
23:15:48.371 INFO  FilterMutectCalls - GCS max retries/reopens: 20
23:15:48.371 INFO  FilterMutectCalls - Requester pays: disabled
23:15:48.371 INFO  FilterMutectCalls - Initializing engine
23:15:48.496 INFO  FeatureManager - Using codec VCFCodec to read file file:///tmp/nxf.KmgEqbjZlB/LS0921.mutect2.raw.vcf.gz
23:15:48.604 INFO  FilterMutectCalls - Done initializing engine
23:15:48.675 INFO  ProgressMeter - Starting traversal
23:15:48.676 INFO  ProgressMeter -        Current Locus  Elapsed Minutes    Variants Processed  Variants/Minute
23:15:48.678 INFO  FilterMutectCalls - Starting pass 0 through the variants
23:15:49.617 INFO  FilterMutectCalls - Finished pass 0 through the variants
23:15:49.997 INFO  FilterMutectCalls - Starting pass 1 through the variants
23:15:50.865 INFO  FilterMutectCalls - Finished pass 1 through the variants
23:15:50.954 INFO  FilterMutectCalls - Starting pass 2 through the variants
23:15:51.782 INFO  FilterMutectCalls - Finished pass 2 through the variants
23:15:51.784 INFO  FilterMutectCalls - Starting pass 3 through the variants
23:15:52.509 INFO  FilterMutectCalls - Finished pass 3 through the variants
23:15:52.515 INFO  FilterMutectCalls - No variants filtered by: AllowAllVariantsVariantFilter
23:15:52.516 INFO  FilterMutectCalls - 0 read(s) filtered by: AllowAllReadsReadFilter 

23:15:52.516 INFO  ProgressMeter -       chr4:105236262              0.1                  9916         154937.5
23:15:52.516 INFO  ProgressMeter - Traversal complete. Processed 9916 total variants in 0.1 minutes.
23:15:52.527 INFO  FilterMutectCalls - Shutting down engine
[June 8, 2026 at 11:15:52 PM GMT] org.broadinstitute.hellbender.tools.walkers.mutect.filtering.FilterMutectCalls done. Elapsed time: 0.07 minutes.
Runtime.totalMemory()=352321536
Using GATK jar /gatk/gatk-package-4.5.0.0-local.jar
Running:
    java -Dsamjdk.use_async_io_read_samtools=false -Dsamjdk.use_async_io_write_samtools=true -Dsamjdk.use_async_io_write_tribble=false -Dsamjdk.compression_level=2 -Xmx14g -jar /gatk/gatk-package-4.5.0.0-local.jar FilterMutectCalls -R hg38.fa -V LS0921.mutect2.raw.vcf.gz --stats LS0921.mutect2.raw.vcf.gz.stats -O LS0921.mutect2.filtered.vcf.gz
23:15:53.925 INFO  NativeLibraryLoader - Loading libgkl_compression.so from jar:file:/gatk/gatk-package-4.5.0.0-local.jar!/com/intel/gkl/native/libgkl_compression.so
23:15:54.037 INFO  SelectVariants - ------------------------------------------------------------
23:15:54.040 INFO  SelectVariants - The Genome Analysis Toolkit (GATK) v4.5.0.0
23:15:54.040 INFO  SelectVariants - For support and documentation go to https://software.broadinstitute.org/gatk/
23:15:54.040 INFO  SelectVariants - Executing as ?@nf-3d2d0aed8b32a32f069823bdaf9bf383-988fd-w28vz on Linux v6.12.88 amd64
23:15:54.040 INFO  SelectVariants - Java runtime: OpenJDK 64-Bit Server VM v17.0.9+9-Ubuntu-122.04
23:15:54.040 INFO  SelectVariants - Start Date/Time: June 8, 2026 at 11:15:53 PM GMT
23:15:54.040 INFO  SelectVariants - ------------------------------------------------------------
23:15:54.040 INFO  SelectVariants - ------------------------------------------------------------
23:15:54.041 INFO  SelectVariants - HTSJDK Version: 4.1.0
23:15:54.041 INFO  SelectVariants - Picard Version: 3.1.1
23:15:54.041 INFO  SelectVariants - Built for Spark Version: 3.5.0
23:15:54.041 INFO  SelectVariants - HTSJDK Defaults.COMPRESSION_LEVEL : 2
23:15:54.041 INFO  SelectVariants - HTSJDK Defaults.USE_ASYNC_IO_READ_FOR_SAMTOOLS : false
23:15:54.041 INFO  SelectVariants - HTSJDK Defaults.USE_ASYNC_IO_WRITE_FOR_SAMTOOLS : true
23:15:54.041 INFO  SelectVariants - HTSJDK Defaults.USE_ASYNC_IO_WRITE_FOR_TRIBBLE : false
23:15:54.041 INFO  SelectVariants - Deflater: IntelDeflater
23:15:54.041 INFO  SelectVariants - Inflater: IntelInflater
23:15:54.041 INFO  SelectVariants - GCS max retries/reopens: 20
23:15:54.042 INFO  SelectVariants - Requester pays: disabled
23:15:54.042 INFO  SelectVariants - Initializing engine
23:15:54.150 INFO  FeatureManager - Using codec VCFCodec to read file file:///tmp/nxf.KmgEqbjZlB/LS0921.mutect2.filtered.vcf.gz
23:15:54.258 INFO  SelectVariants - Done initializing engine
23:15:54.296 INFO  ProgressMeter - Starting traversal
23:15:54.297 INFO  ProgressMeter -        Current Locus  Elapsed Minutes    Variants Processed  Variants/Minute
23:15:54.358 INFO  ProgressMeter -         chr7:6401978              0.0                  2479        2521016.9
23:15:54.358 INFO  ProgressMeter - Traversal complete. Processed 2479 total variants in 0.0 minutes.
23:15:54.369 INFO  SelectVariants - Shutting down engine
[June 8, 2026 at 11:15:54 PM GMT] org.broadinstitute.hellbender.tools.walkers.variantutils.SelectVariants done. Elapsed time: 0.01 minutes.
Runtime.totalMemory()=335544320
Using GATK jar /gatk/gatk-package-4.5.0.0-local.jar
Running:
    java -Dsamjdk.use_async_io_read_samtools=false -Dsamjdk.use_async_io_write_samtools=true -Dsamjdk.use_async_io_write_tribble=false -Dsamjdk.compression_level=2 -Xmx14g -jar /gatk/gatk-package-4.5.0.0-local.jar SelectVariants -R hg38.fa -V LS0921.mutect2.filtered.vcf.gz --exclude-filtered true -O LS0921.mutect2.pass.vcf.gz